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Jing Yang, Sheng Zhou, Dalu Zhang, Jianjun Gu, Yizhi liu; Unfolded protein response activation in Human Primary Pterygium. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4365.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the UPR activation in human primary pterygium.
Human primary pterygium specimens and normal Tenon's capsule specimens were obtained and processed within two hours from primary pterygium patients after excision surgery or from fresh cadaver normal human eyes. The mRNA levels of UPR related factors in the human primary pterygium tissue were detected by real-time PCR assay. The UPR related proteins levels were detected by immunohistochemical staining and Western blot analysis.
The UPR related genes transcription level and protein expression level were both increased in human primary pterygium group when compared with the normal control.
These results suggest that the three UPR pathways are all activated in the human primary pterygium tissue, which indicates the involvement of ER stress in the progress of pterygium and the potential mechanism as ER stress induced inflammation for the pterygium.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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