June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Tumor pigmentation in Uveal melanoma is related to eye color
Author Affiliations & Notes
  • Annemijn P.A. Wierenga
    Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands
  • Mehmet Dogrusöz
    Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands
  • Wilma Kroes
    Department of Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands
  • Sjoerd G. van Duinen
    Department of Pathology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands
  • Gregorius P M Luyten
    Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands
  • Martine J Jager
    Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands
  • Footnotes
    Commercial Relationships   Annemijn Wierenga, None; Mehmet Dogrusöz, None; Wilma Kroes, None; Sjoerd van Duinen, None; Gregorius Luyten, None; Martine Jager, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4417. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Annemijn P.A. Wierenga, Mehmet Dogrusöz, Wilma Kroes, Sjoerd G. van Duinen, Gregorius P M Luyten, Martine J Jager; Tumor pigmentation in Uveal melanoma is related to eye color
      . Invest. Ophthalmol. Vis. Sci. 2017;58(8):4417.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Differences in tumor location and prognosis have been described for uveal melanoma in blue versus brown eyes. [1, 2] Green eyes are often not mentioned. However, when analysing the type of melanin, green and blue eyes show similar levels in quantity and ratio of eumelanin and pheomelanin, with brown eyes showing higher levels.[3] We wondered whether uveal melanoma in green eyes were more similar to UM in blue eyes than in brown eyes.

Methods : We performed a retrospective cohort study and analyzed 237 eyes that have been primarily enucleated for UM. Of this cohort, 157 had blue/grey, 41 green/hazel and 39 (dark)brown irises. We compared clinical and histological data. Pigmentation was derived from the histological report.

Results : UM in green eyes (n = 41) tended to be less frequently located in the ciliary body (P = 0.05), but otherwise were clinically not significantly different from blue/grey (n =157) or brown eyes (n =39). Also, survival of UM patients with green eyes was not significantly different compared to UM in blue- or brown eyed patients (P = 0.935). However, a clear difference was observed with regard to pigmentation. Histopathologically, 72% Of the UM eyes with green irises had minor to no pigmentation, compared to 26% and 53% in UM eyes with a (dark)brown iris and blue/grey iris, respectively (P <0.001).

Conclusions : The degree of pigmentation of a uveal melanoma is related to the color of the iris. UM-containing eyes with a brown or dark brown iris reveal high levels of pigmentation, with UM in eyes with green irisis showing much less pigment. This finding is also of clinical relevance to the treatment of UM, since treatment with photodynamic light therapy (PDT) is significantly influenced by the degree of pigmentation in the tumor.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×