June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Preoperative brimonidine tartrate 0.2% effect on intraocular pressure of patients undergoing robot-assisted radical laparoscopic prostatectomy in steep Trendelenburg position
Author Affiliations & Notes
  • Rana Greene
    Ophthalmology, University of Toronto, Toronto, Ontario, Canada
  • Graham Eric Trope
    Ophthalmology, University of Toronto, Toronto, Ontario, Canada
  • Matteo Parotto
    Ophthalmology, University of Toronto, Toronto, Ontario, Canada
  • Antonio Finelli
    Ophthalmology, University of Toronto, Toronto, Ontario, Canada
  • Numan Hallaji
    Ophthalmology, University of Toronto, Toronto, Ontario, Canada
  • Yaping Jin
    Ophthalmology, University of Toronto, Toronto, Ontario, Canada
  • Yvonne M Buys
    Ophthalmology, University of Toronto, Toronto, Ontario, Canada
  • Footnotes
    Commercial Relationships   Rana Greene, None; Graham Trope, None; Matteo Parotto, None; Antonio Finelli, None; Numan Hallaji, None; Yaping Jin, None; Yvonne Buys, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4587. doi:
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      Rana Greene, Graham Eric Trope, Matteo Parotto, Antonio Finelli, Numan Hallaji, Yaping Jin, Yvonne M Buys; Preoperative brimonidine tartrate 0.2% effect on intraocular pressure of patients undergoing robot-assisted radical laparoscopic prostatectomy in steep Trendelenburg position. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4587.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Postoperative visual field (VF) defects and vision loss secondary to intraocular pressure (IOP) spikes have been reported with robot-assisted radical laparoscopic prostatectomy (RALP) in steep Trendelenburg position (sTBURG). This study evaluated the effect of preoperative brimonidine on IOP during RALP in sTBURG.

Methods : In this prospective randomized controlled masked interventional trial (# NCT02818816), patients scheduled for RALP in sTBURG at University Health Network were screened. Exclusion criteria included diagnosis of glaucoma or ocular hypertension. With informed consent, subjects were randomized to right or left eye. Study eyes were randomized to placebo (artificial tears) or drug (brimonidine tartrate 0.2%) preoperatively. Comprehensive eye exam was done preoperatively and 1-month postoperatively including visual acuity (VA), tonometry, disc photography, VF and retinal nerve fiber layer (RNFL) assessments. A standardized anesthesia protocol was followed intraoperatively. Tono-Pen IOP measurements were recorded bilaterally as follows: pre-anesthesia, anaesthetized supine, hourly in sTBURG and awake supine. The mean of 3 IOP readings each within 2 mmHg was recorded with 5% confidence interval. Primary outcome was IOP. Secondary outcomes were changes in VA, VF and RNFL. Planned sample size is 26 subjects. Study was approved by University Health Network Research Ethics Board.

Results :
To date, 5 of 7 recruited patients completed the study (2 brimonidine, 3 placebo). Significant IOP elevation was noted in control, placebo & drug treated eyes at 1 hour of sTBURG. IOP remained elevated during sTBURG. Mean IOP during sTBURG was 31.4±3.6, 30.8±2.4 and 35.9±6.7 mmHg in control, placebo and drug treated eyes respectively, p=0.11 for drug versus placebo. Highest IOP recorded was 44 mmHg at 1 hour of sTBURG, an IOP spike of 30 mmHg from baseline in a drug treated eye. IOP returned to baseline in 8 of 10 eyes 30 minutes after supine positioning. No significant changes were noted in VA, VF or RNFL.

Conclusions : Significant, sustained IOP increase occurs during sTBURG. Early data suggests preoperative brimonidine may not prevent IOP spikes. Enrolment is ongoing.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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