June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Optical coherence tomography angiography analysis of the foveal avascular zone and macular vessel density after anti-VEGF therapy in eyes with diabetic macular edema and retinal vein occlusion
Author Affiliations & Notes
  • Nicholas Iafe
    Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    Jules Stein Eye Institute - UCLA, Los Angeles, California, United States
  • Khalil Ghasami Falavarjani
    Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Jean-Pierre Hubschman
    Jules Stein Eye Institute - UCLA, Los Angeles, California, United States
  • Irena Tsui
    Jules Stein Eye Institute - UCLA, Los Angeles, California, United States
  • Srinivas R Sadda
    Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
  • David Sarraf
    Jules Stein Eye Institute - UCLA, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Nicholas Iafe, None; Khalil Falavarjani, None; Jean-Pierre Hubschman, Alcon (C), Allergan (R); Irena Tsui, None; Srinivas Sadda, Allergan (C), Allergan (F), Carl Zeiss Meditec (F), Genentech (C), Genentech (F), Iconic (C), Novartis (C), Optos (C), Optos (F), Thrombogenics (C); David Sarraf, Allergan (F), Bayer (C), Genentech (F), Genentech (C), Heidelberg (F), Novartis (R), Optovue (F), Optovue (C), Optovue (R), Regeneron (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4632. doi:
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      Nicholas Iafe, Khalil Ghasami Falavarjani, Jean-Pierre Hubschman, Irena Tsui, Srinivas R Sadda, David Sarraf; Optical coherence tomography angiography analysis of the foveal avascular zone and macular vessel density after anti-VEGF therapy in eyes with diabetic macular edema and retinal vein occlusion. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4632.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the changes in foveal avascular zone (FAZ) area and the retinal capillary density after a single intravitreal anti-vascular endothelial growth factor (VEGF) injection for macular edema secondary to diabetic retinopathy or retinal vein occlusion.

Methods : In this prospective non-comparative case series, 18 eyes of 15 patients with diabetic macular edema (13 eyes) or macular edema secondary to central retinal vein occlusion (5 eyes) were included. Optical coherence tomography angiography images were obtained, and retinal capillary vessel density and FAZ area were measured in the foveal and parafoveal regions at the level of the superficial (SCP) and deep retinal capillary plexus (DCP) before and at the first visit after intravitreal injection.

Results : The mean interval between baseline and follow up OCTA was 32.5±9.4 (range 21-50) days. Foveal and parafoveal vessel density in the SCP and DCP were not significantly different before and after intravitreal injection (all P>0.1), nor was FAZ area (P=0.48 and P=0.42, respectively). No significant difference was found between eyes with diabetic macular edema and those with retinal vein occlusion with respect to the mean change of vessel density and FAZ area (all P>0.05).

Conclusions : In this pilot study, retinal capillary density and FAZ area remained statistically unchanged in the short-term after a single intravitreal injection of an anti-VEGF agent.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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