June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
OCT-ANGIOGRAPHY OF QUIESCENT CNV IN ANGIOID STREAKS
Author Affiliations & Notes
  • Giorgio Panozzo
    Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy, Milan, Italy
  • Eleonora Corbelli
    Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy, Milan, Italy
  • alessandro marchese
    Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy, Milan, Italy
  • Adriano Carnevali
    Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy, Milan, Italy
    Ophthalmology, University of “Magna Graecia”, Catanzaro, Italy, Catanzaro, Italy
  • Maria Vittoria Cicinelli
    Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy, Milan, Italy
  • Michele Cavalleri
    Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy, Milan, Italy
  • Lea Querques
    Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy, Milan, Italy
  • Riccardo Sacconi
    Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy, Milan, Italy
    Ophthalmology, University of Verona, University hospital of Verona, Verona, Verona, Italy
  • Francesco Bandello
    Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy, Milan, Italy
  • Giuseppe Querques
    Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy, Milan, Italy
  • Footnotes
    Commercial Relationships   Giorgio Panozzo, None; Eleonora Corbelli, None; alessandro marchese, None; Adriano Carnevali, None; Maria Vittoria Cicinelli, None; Michele Cavalleri, None; Lea Querques, None; Riccardo Sacconi, None; Francesco Bandello, Alcon (C), Alimera Sciences (C), Allergan Inc (C), Bausch And Lomb (C), Bayer Shering-Pharma (C), Farmila-Thea (C), Genentech (C), Hoffmann-La-Roche (C), NovagaliPharma (C), Novartis (C), Sanofi-Aventis (C), Thrombogenics (C), Zeiss (C); Giuseppe Querques, Alimera Sciences (C), Allergan Inc (C), Bayer Shering-Pharma (C), Heidelberg (C), Novartis (C), Zeiss (C)
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4636. doi:
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      Giorgio Panozzo, Eleonora Corbelli, alessandro marchese, Adriano Carnevali, Maria Vittoria Cicinelli, Michele Cavalleri, Lea Querques, Riccardo Sacconi, Francesco Bandello, Giuseppe Querques; OCT-ANGIOGRAPHY OF QUIESCENT CNV IN ANGIOID STREAKS. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4636.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Choroidal neovascularization (CNV) is by far the most common cause of visual loss in patients affected by angioid streaks (AS). Optical coherence tomography angiography (OCT-A) is a new imaging technique able to detect treatment-naïve quiescent CNV along the AS. The aim of this study is to estimate the prevalence of treatment-naïve quiescent CNV in angioid streaks and to investigate their OCT-A features.

Methods : We retrospectively analyzed treatment-naïve subjects affected by AS without exudative choroidal neovascularization (CNV). All patients underwent standard multimodal imaging, including multicolor imaging, infrared retinography (IR), blue autofluorescence (BAF), fluorescence angiography (FA), structural OCT and OCT-A (Angioplex™, CIRRUS HD-OCT models 5000, Carl Zeiss Meditec, Inc., Dublin, USA). Then, we identified treatment-naïve CNV along AS and studied their OCT-A features.

Results : We included 12 eyes of 6 subjects (5 males and 1 female, age 50±18 years) affected by AS. We analysed 27 angioid streaks by means of OCT-A. In seven out of 27 AS, choriocapillary segmentation of OCT-A revealed an irregular vascular network representing treatment-naïve quiescent CNV. Interestingly, they appeared on structural OCT as flat irregular elevation of the retinal pigment epithelium (RPE) with hyper-reflective accumulations above the Bruch’s Membrane (BM), without intra/subretinal hyporeflective fluid.

Conclusions : OCT-A is able to detect the presence of treatment-naïve quiescent CNV along AS, in areas of flat irregular elevation of the RPE as visualized by structural OCT.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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