June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Correlation between visual cortex activation and macular parameters in patients with Stargardt disease.
Author Affiliations & Notes
  • Francesco Maria D'Alterio
    Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy
  • Paolo Melillo
    Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy
  • Michele Della Corte
    Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy
  • Gaia Olivo
    Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy
  • Sirio Cocozza
    Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy
  • Anna Prinster
    Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy
  • Arturo Brunetti
    Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy
  • Mario Quarantelli
    Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy
  • Francesco Testa
    Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy
  • Francesca Simonelli
    Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy
  • Footnotes
    Commercial Relationships   Francesco Maria D'Alterio, None; Paolo Melillo, Sanofi (C); Michele Della Corte, None; Gaia Olivo, None; Sirio Cocozza, None; Anna Prinster, None; Arturo Brunetti, None; Mario Quarantelli, None; Francesco Testa, Sanofi (C); Francesca Simonelli, Sanofi (C), Spark Therapeutics (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4645. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Francesco Maria D'Alterio, Paolo Melillo, Michele Della Corte, Gaia Olivo, Sirio Cocozza, Anna Prinster, Arturo Brunetti, Mario Quarantelli, Francesco Testa, Francesca Simonelli; Correlation between visual cortex activation and macular parameters in patients with Stargardt disease.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4645.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Primary visual cortex (VC) contains a retinotopic map in which the central visual field (CVF) is highly magnified with respect to the peripheral field. Several studies have used functional magnetic resonance imaging (fMRI) to assess the reorganization of visual processing and correlation with the extrafoveal preferred retinal locus (PRL) in macular degenerations. We evaluated the functional response in VC and its correlation with macular parameters in patients with Stargardt disease due to ABCA4 mutations (STGD1).

Methods : 24 patients (aged 29.2±11.8 years; 8F) with STGD1 were enrolled and underwent ocular examination: best corrected visual acuity (BCVA) measured with ETDRS chart; microperimetry to assess mean macular sensitivity (MS), dense scotoma size (DSS) and PRL eccentricity (PRL-E); full field standard electroretinogram (ERG); optical coherence tomography to measure retinal pigmented epithelium atrophy area (RPE-A). Furthermore, patients underwent fMRI to assess cerebral activation during visual stimulation by a flickering checkerboard in four VC subdivisions, corresponding to 0°-5° (V1), 5°-10° (V2), 10°-15° (V3), and 15°-40° (V4) of CVF. Linear regression analysis was performed to estimate the relationship between VC activation and ophthalmological parameters (significant p-value if < 0.05). The study adhered to Declaration of Helsinki and received approval by the Local Ethics Committee; each patient gave informed consent.

Results : The regression analysis showed that higher values of ERG responses (i.e., b-wave 0.01 dark adapted, b-wave light adapted 3.0 and 30 Hz Flicker amplitudes) were significantly (p<0.001) associated with larger functional cerebral response in V1, V2 and V3 subdivisions. Moreover, activation in V1 subdivision was significantly associated with higher value of MS (p=0.004) and smaller DSS (p=0.003). No significant relationship was observed between VC activation and PRL-E. Finally, larger RPE-A was significantly (p<0.05) associated with smaller VC activation in V1, V2 and V3 subdivisions.

Conclusions : Our results show stronger VC activation in patients with a more preserved retinal function and macular structure. Furthermore, our study data support the hypothesis proposed by the recent literature of lack of neuronal reorganization in macular degeneration.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×