June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
The correlation between visual function and morphologic changes in retinal vein occlusion
Author Affiliations & Notes
  • RYOSUKE FUJINO
    The university of tokyo, Bunkyoku, Tokyo, Japan
  • Tatsuya Inoue
    The university of tokyo, Bunkyoku, Tokyo, Japan
  • Keiko Azuma
    The university of tokyo, Bunkyoku, Tokyo, Japan
  • Hiroshi Murata
    The university of tokyo, Bunkyoku, Tokyo, Japan
  • Ryo Asaoka
    The university of tokyo, Bunkyoku, Tokyo, Japan
  • Ryo Obata
    The university of tokyo, Bunkyoku, Tokyo, Japan
  • Footnotes
    Commercial Relationships   RYOSUKE FUJINO, None; Tatsuya Inoue, None; Keiko Azuma, None; Hiroshi Murata, None; Ryo Asaoka, None; Ryo Obata, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4707. doi:
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      RYOSUKE FUJINO, Tatsuya Inoue, Keiko Azuma, Hiroshi Murata, Ryo Asaoka, Ryo Obata; The correlation between visual function and morphologic changes in retinal vein occlusion. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4707.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To estimate the correlation between visual function and retinal morphologic changes in retinal vein occlusion (RVO)

Methods : 17eyes of 17 patients with macular edema secondary to RVO were enrolled in the current study and were injected with anti-VEGF agents. Before and after the treatment, central retinal thickness (CRT) and macular volume of the central 2 mm circle (MV) were measured, using spectral-domain optical coherence tomography (SD-OCT) as retinal morphologic parameters. The best-corrected visual acuity (BCVA) and the mean retinal sensitivity of the 9 measured points in the central 4-degrees(MRS) were evaluated as visual functions. The MRS was measured with the microperimetry (MP-3,Nidek) . We investigated the correlation between visual functions and retinal morphologic parameters, using multivariate regression analyses.

Results : Mean age of participants was72.35±6.13 years. All 17eyes of 17 patients gained the dry retinas after anti-VEGF treatments. The MRS showed a significant improvement from baseline after the treatment (baseline vs post; 19.56±5.18 vs 21.19±4.90 dB, p=0.032). However, mean BCVA did not show a significant improvement. (baseline vs post; 0.29±0.34 vs 0.21±0.25, p=0.14).
Multivariate regression analysis showed that the preoperative MRS was adopted as an explanatory variable for preoperative BCVA (AICc=2.76). When the preoperative MV was selected as a response variable, the preoperative MRS was adopted as the explanatory variable (AICc=8.57). The changes of MRS were significantly correlated with those of MV (p=0.026). However, there was no significant correlation between MRS and CRT changes.

Conclusions : The present study showed that the retinal sensitivity may be effective as the parameter which is associated with retinal morphologic changes after the anti-VEGF treatment for RVO.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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