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Olivia Zambrowski, Caroline Bottin, Julie Racine, Salomon Y Cohen, Camille JUNG, Alexandra Miere, Eric Souied; Electrophysiological Findings in Non Proliferative Sickle Cell Retinopathy according to Hemoglobin type. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4892.
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© ARVO (1962-2015); The Authors (2016-present)
To characterize full-field electroretinogram (ffERG) in patients with early sickle-cell retinopathy according to hemoglobin type.
In this pilot study, we included patients with non proliferative sickle-cell retinopathy, with bilateral preserved visual acuity (>20/25), between November 2014 to April 2016. All patient underwent a ffERG, according to the ISCEV standards. Six eyes of healthy patients were used as control group. Scotopic ERG responses as a, b wave amplitudes and b/a ratio of the dark adapted (DA) 3.0 and 10.0 cd.s.m-2 stimulation were the primary outcome measures. Result analysis was performed according to hemoglobin type (HbSS or HbSC) and compared to the control group.
Eighteen patients were included: 6 HbSS; 6 HbSC and 6 healthy patients. Comparison between the HbSS group and the HbSC group revealed that the b wave amplitude and b/a ratio of DA3.0 (respectively p=0.037 and p=0.0006) and of DA10.0 (respectively p=0.043 and p=0.0010) ERG response was significantly lower in the HbSS group. However, no differences were found in the a wave amplitude of both DA3.0 and 10.0 in either group.
Dark adapted ERG response in the HbSS group suggests an early involvement of the inner retina, which may explain the fact that HbSS patients have a lower incidence of proliferative lesions, compared to HbSC patients.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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