June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Electrophysiological Findings in Non Proliferative Sickle Cell Retinopathy according to Hemoglobin type

Author Affiliations & Notes
  • Olivia Zambrowski
    Ophthalmology, Centre hospitalier intercommunal de Creteil, Creteil, France
  • Caroline Bottin
    Ophthalmology, Centre hospitalier intercommunal de Creteil, Creteil, France
  • Julie Racine
    Ophthalmology, National wide hospital, Columbus, Ohio, United States
  • Salomon Y Cohen
    Ophthalmology, Centre hospitalier intercommunal de Creteil, Creteil, France
  • Camille JUNG
    Ophthalmology, Centre hospitalier intercommunal de Creteil, Creteil, France
  • Alexandra Miere
    Ophthalmology, Centre hospitalier intercommunal de Creteil, Creteil, France
  • Eric Souied
    Ophthalmology, Centre hospitalier intercommunal de Creteil, Creteil, France
  • Footnotes
    Commercial Relationships   Olivia Zambrowski, None; Caroline Bottin, None; Julie Racine, None; Salomon Cohen, None; Camille JUNG, None; Alexandra Miere, None; Eric Souied, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4892. doi:
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    • Get Citation

      Olivia Zambrowski, Caroline Bottin, Julie Racine, Salomon Y Cohen, Camille JUNG, Alexandra Miere, Eric Souied; Electrophysiological Findings in Non Proliferative Sickle Cell Retinopathy according to Hemoglobin type

      . Invest. Ophthalmol. Vis. Sci. 2017;58(8):4892.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To characterize full-field electroretinogram (ffERG) in patients with early sickle-cell retinopathy according to hemoglobin type.

Methods : In this pilot study, we included patients with non proliferative sickle-cell retinopathy, with bilateral preserved visual acuity (>20/25), between November 2014 to April 2016. All patient underwent a ffERG, according to the ISCEV standards. Six eyes of healthy patients were used as control group. Scotopic ERG responses as a, b wave amplitudes and b/a ratio of the dark adapted (DA) 3.0 and 10.0 cd.s.m-2 stimulation were the primary outcome measures. Result analysis was performed according to hemoglobin type (HbSS or HbSC) and compared to the control group.

Results : Eighteen patients were included: 6 HbSS; 6 HbSC and 6 healthy patients. Comparison between the HbSS group and the HbSC group revealed that the b wave amplitude and b/a ratio of DA3.0 (respectively p=0.037 and p=0.0006) and of DA10.0 (respectively p=0.043 and p=0.0010) ERG response was significantly lower in the HbSS group. However, no differences were found in the a wave amplitude of both DA3.0 and 10.0 in either group.

Conclusions : Dark adapted ERG response in the HbSS group suggests an early involvement of the inner retina, which may explain the fact that HbSS patients have a lower incidence of proliferative lesions, compared to HbSC patients.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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