June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Clinicopathological features of canine spontaneous glaucomas surgically treated via cyclodestructive and filtering techniques.
Author Affiliations & Notes
  • Leandro B C Teixeira
    Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
    Comparative Ocular Pathology Laboratory of Wisconsin, University of Wisconsin-Madison, Madison, Wisconsin, United States
  • Footnotes
    Commercial Relationships   Leandro Teixeira, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4999. doi:
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      Leandro B C Teixeira; Clinicopathological features of canine spontaneous glaucomas surgically treated via cyclodestructive and filtering techniques.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4999.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To report the clinicopathological features of enucleated canine globes clinically diagnosed with glaucoma and surgically treated with cyclodestructive and filtering techniques.

Methods : The database of the Comparative Ocular Pathology Laboratory of Wisconsin was searched and 81 dogs diagnosed with glaucoma and surgically treated via transcleral and endolaser photocoagulation and/or filtering devices were identified. Patient data, clinical history and light microscopic lesions were recorded. Enucleated eyes were formalin-fixed-paraffin-embedded and sections stained with H&E.

Results : 48 cases that underwent cyclodestructive and 33 cases of filtering procedures were identified. The median age of the affected animals was 8 years (range 1-13). Females were 57% and males 43% of cases. The most common breeds affected were Basset hounds (16%), Cocker spaniels (14%) and Labrador retrievers (5.8%). 63% of cases were diagnosed with primary glaucoma, 30% secondary and 7% idiopathic glaucoma. All filtering technique cases received Ahmed valves. OU was treated in 8% of cases and OS and OD 46% of cases each. Median time from treatment to enucleation was 105 days (range 2-1095 days). Most common reasons for enucleation were uncontrollable IOP (87%) and corneal perforation (6%). Most common causes for failure were neovascular glaucoma (18%), bleb failure (15%), suppurative endophthalmitis (12%), collagenolytic keratitis (6%) and uveitis (6%). Common microscopic findings were bleb fibrosis and corneal endothelial degeneration. Of the cyclodestructive cases 58.3% were treated with transcleral and 41.7% with endolaser photocoagulation. OU was treated in 18.8% of cases, OS in 35.4% and OD in 47.6% of cases. Median time from treatment to enucleation was 90 days (range 1-2160 days). Most common reasons for enucleation were uncontrollable IOP (87.5%) and corneal perforation (9%). Most common causes for failure were neovascular glaucoma (42.6%), primary glaucoma (21.3%), tumors (8.5%), endophthalmitis (6%) and uveitis (6%). Common microscopic findings were laser coagulation of scleral collagen and ciliary body epithelium and intraocular fibrovascular membranes.

Conclusions : Despite differences in anatomy and surgical techniques, cyclodestructive and filtering glaucoma surgery in dogs with spontaneous glaucomas presented relatively similar success rates and complications compared to humans.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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