June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Quantifying Visual Photosensitivity in Veterans with Traumatic Brain Injury
Author Affiliations & Notes
  • Mariela C Aguilar
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Industrial Engineering, College of Engineering, University of Miami, Coral Gables, Florida, United States
  • Alex Gonzalez
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Cornelis J. Rowaan
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Anat Galor
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, United States
    VA Medical Center, Miami, Florida, United States
  • Ninel Gregori
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, United States
    VA Medical Center, Miami, Florida, United States
  • Heather Ann Durkee
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Potyra R Rosa
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Byron L Lam
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Jean-Marie A Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Brien Holden Vision Institute and Vision Cooperative Research Centre, Sydney, New South Wales, Australia
  • Shihab S Asfour
    Department of Industrial Engineering, College of Engineering, University of Miami, Coral Gables, Florida, United States
  • Footnotes
    Commercial Relationships   Mariela Aguilar, None; Alex Gonzalez, None; Cornelis Rowaan, None; Anat Galor, None; Ninel Gregori, None; Heather Durkee, None; Potyra Rosa, None; Byron Lam, None; Jean-Marie Parel, None; Shihab Asfour, None
  • Footnotes
    Support  NEI R24 EY022023, DAMD-W81XWH-09-1-0675, DOD Warfighters Grant W81XWH-13-1-0048, Florida Lions Eye Bank, Drs. KR Olsen & ME Hildebrandt, Drs. Raksha Urs & Aaron Furtado, Brien Holden Vision Institute, NIH Center Grant P30EY14801, Research to Prevent Blindness, Henri and Flore Lesieur Foundation (JMP).
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5136. doi:
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    • Get Citation

      Mariela C Aguilar, Alex Gonzalez, Cornelis J. Rowaan, Anat Galor, Ninel Gregori, Heather Ann Durkee, Potyra R Rosa, Byron L Lam, Jean-Marie A Parel, Shihab S Asfour; Quantifying Visual Photosensitivity in Veterans with Traumatic Brain Injury. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5136.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Traumatic brain injury (TBI) is a significant health issue which affects service members and veterans during times of both peace and war. The Department of Defense and the Defense and Veteran's Brain Injury Center estimate that 22% of all combat casualties are brain injuries. The purpose of this study was to determine if visual photosensitivity thresholds (VPT) in veterans with TBI could be quantified using the Ocular Photosensitivity Analyzer (OPA) and compare the results with healthy subjects.

Methods : The OPA (Aguilar MC, et al. IOVS, 2016; 57(12):622) produces a light stimuli with varying intensities from 1 to 32,000 lux (0 to 4.51 log lux). The subject is instructed by the OPA to indicate whether the light stimulus is “uncomfortable” by pressing a hand-held button. After 10 response reversals, the VPT is automatically calculated. To ensure reliability, catch trials were incorporated throughout the test. We compared the VPT of healthy and TBI subjects presenting with light sensitivity symptoms. Three TBI subjects (3 males, age = 64 ± 19) with occurrence of injuries varying in time (2-6 decades), and nine healthy subjects (5 females and 4 males, age = 31.4 ± 7.6) were tested under an IRB approved protocol.

Results : The healthy and TBI subjects were found to have a mean predicted VPT of 3.24±0.63 and 0.35±0.61 log lux, respectively. A one-way analysis of variance showed a statistically significant difference (p<0.0001) between the healthy and TBI subject groups.

Conclusions : The OPA is a safe and sensitive instrument capable of determining VPT in both healthy and TBI subjects. The findings demonstrate a significant difference in VPT between the groups. Ongoing studies are being performed with the OPA to increase our subject population and further validate our findings. Furthermore, as treatments for TBI are being developed the OPA has the potential to be utilized as an outcome measure in studies that would warrant a pre-treatment baseline and post-treatment VPT.

Acknowledgements: Supported in part by: NEI R24 EY022023, DAMD-W81XWH-09-1-0675, DOD Warfighters W81XWH-13-1-0048, Florida Lions Eye Bank, Drs. KR Olsen & ME Hildebrandt, Drs. Raksha Urs & Aaron Furtado, Brien Holden Vision Institute, NIH P30EY14801, Research to Prevent Blindness, Henri and Flore Lesieur Foundation (JMP). Technical support provided by: F Manns, DH Sliney, C de Freitas, K Alawa, A Arboleda, A Bernal, J Silgado, N Salas, N Relhan, & WJ Feuer.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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