June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Correlation Between Histopathology and Optical Coherence Tomography in Periocular Tumors
Author Affiliations & Notes
  • Denise Miyamoto
    MUHC-McGill University Ocular Pathology Laboratory, Montreal, Canada, Montreal, Quebec, Canada
  • Sabrina Bergeron
    MUHC-McGill University Ocular Pathology Laboratory, Montreal, Canada, Montreal, Quebec, Canada
  • Bryan Arthurs
    Ophthalmology, McGill University, Montreal, Quebec, Canada
  • Debra-Meghan Sanft
    Ophthalmology, McGill University, Montreal, Quebec, Canada
  • Christina Mastromonaco
    MUHC-McGill University Ocular Pathology Laboratory, Montreal, Canada, Montreal, Quebec, Canada
  • Miguel N Burnier
    MUHC-McGill University Ocular Pathology Laboratory, Montreal, Canada, Montreal, Quebec, Canada
  • Footnotes
    Commercial Relationships   Denise Miyamoto, None; Sabrina Bergeron, None; Bryan Arthurs, None; Debra-Meghan Sanft, None; Christina Mastromonaco, None; Miguel Burnier, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5145. doi:
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      Denise Miyamoto, Sabrina Bergeron, Bryan Arthurs, Debra-Meghan Sanft, Christina Mastromonaco, Miguel N Burnier; Correlation Between Histopathology and Optical Coherence Tomography in Periocular Tumors. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5145.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Basal cell carcinoma (BCC) accounts for 90% of the eyelid malignancies followed by sebaceous cell carcinoma (SC) and squamous cell carcinoma (SCC). Even though biopsy for histopathological (HP) evaluation remains the gold standard for confirming the diagnosis of eyelid tumors and the status of surgical margins, non-invasive techniques such as dermoscopy and optical coherence tomography (OCT) may increase diagnostic sensitivity and contribute to more accurate delineation of surgical margins. The purpose of this prospective study was to correlate the HP and OCT findings of eyelid malignancies.

Methods : After ethics committee approval (BCC/2017-2608), patients with suspected eyelid carcinomas had photographs taken, surgical margins assessed clinically and using dermoscopy and OCT, which were subsequently compared with HP evaluation. We obtained OCT images of periorbital tumors with an anterior segment lens adjusted in an Optovue Avanti. The histopathology was evaluated using a digital pathology system. Patients under 18 years old were excluded from this study.

Results : Three female and three male patients (age 69-88 years) with lesions located in the lower periorbital area (n=5) and upper eyelid (n=1) were included in this study. Two participants previously had skin cancer: 1 female patient had a lentigo maligna and a BCC, and 1 male patient had multiple BCC and actinic keratosis due to immunosuppression related to a liver transplant. Clinical and dermatoscopic diagnosis were accurate in four cases: 3 BCC and 1 SCC. One clinically suspicious BCC was diagnosed as SC and one patient had a previous confirmed diagnosis of SC. All OCT images showed disruption of the dermoepidermal junction and hyporeflective areas in the dermis, which were darker and well-delineated in the three confirmed BCCs. OCT also clearly demarcated the transition between tumor and normal skin in all cases.

Conclusions : Optical coherence tomography (OCT) is a fast and non-invasive exam to acquire high-resolution images of intraocular and ocular surface structures. Preliminary data from our study indicates that real-time OCT images correlate with HP findings and can also help delineate tumor margins. The inclusion of additional participants will provide further evidence of the benefits of using OCT pre-operatively to safely minimize surgical margins during eyelid tumor excision.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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