June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
The inhibitory effect of substance P on retinal neurodegeneration with diabetic rat model
Author Affiliations & Notes
  • Eung-Suk Kim
    Ophthalmology, Kyung Univ Medical Center, Seoul, Korea (the Republic of)
  • Kiyoung Kim
    Ophthalmology, Kyung Univ Medical Center, Seoul, Korea (the Republic of)
  • Hong Hyun Sook
    Kyung Hee Institute of Regenerative Medicine, Kyung Hee University Hospital, Seoul, Korea (the Republic of)
  • Seung-Young Yu
    Ophthalmology, Kyung Univ Medical Center, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Eung-Suk Kim, None; Kiyoung Kim, None; Hong Hyun Sook, None; Seung-Young Yu, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5221. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Eung-Suk Kim, Kiyoung Kim, Hong Hyun Sook, Seung-Young Yu; The inhibitory effect of substance P on retinal neurodegeneration with diabetic rat model. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5221.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To evaluate inhibition effect of retinal neurodegeneration change in Type 2 diabetic rats (OLETF) after intravenous Substance P (SP) injection

Methods : Retinal nerve fiber layer (RNFL) thicknesses were measured manually at 1300 μm from the center of the optic nerve head using SD-OCT. 5nmole/kg Substance P was injected intravenously twice a week from 27 to 30 weeks. Histologic and immunologic cell staining, serum inflammatory cytokines, and bone marrow colony forming efficiency were measured at 31 week

Results : At 28 weeks, RNFL thickness was significantly lower in OLETF than control group. From 29 weeks (2 weeks after injection) RNFL thickness showed significant increase in SP injection group maintained by 31 weeks. In histologic analysis, SP injection group presented decrease of GFAP staining, cell apoptosis, and serum inflammatory cytokines. Whereas, infiltration of inflammatory cells and bone marrow colony forming efficiency were higher than control group

Conclusions : Substance P injection showed inhibitory effect in retinal neurodegeneration as early change of diabetic retinopathy via anti-inflammatory effect and enhancements of mesenchymal stem cells-mediated immune modulation

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×