June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Laser Tissue Evaluation for a Novel Ultrashort Femtosecond Laser with Auto-Z Calibration
Author Affiliations & Notes
  • Nima Khatibzadeh
    Abbott Medical Optics, San Jose, California, United States
  • Alireza Malek Tabrizi
    Abbott Medical Optics, San Jose, California, United States
  • James E Hill
    Abbott Medical Optics, San Jose, California, United States
  • Saidur Rahaman
    Abbott Medical Optics, San Jose, California, United States
  • Zenon Witowski
    Abbott Medical Optics, San Jose, California, United States
  • Zheng Sun
    Abbott Medical Optics, San Jose, California, United States
  • Saeed Taheri
    Abbott Medical Optics, San Jose, California, United States
  • Hong Fu
    Abbott Medical Optics, San Jose, California, United States
  • Footnotes
    Commercial Relationships   Nima Khatibzadeh, Abbott Medical Optics (E); Alireza Malek Tabrizi, Abbott Medical Optics (E); James Hill, Abbott Medical Optics (E); Saidur Rahaman, Abbott Medical Optics (E); Zenon Witowski, Abbott Medical Optics (E); Zheng Sun, Abbott Medical Optics (E); Saeed Taheri, Abbott Medical Optics (E); Hong Fu, Abbott Medical Optics (E)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5292. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Nima Khatibzadeh, Alireza Malek Tabrizi, James E Hill, Saidur Rahaman, Zenon Witowski, Zheng Sun, Saeed Taheri, Hong Fu; Laser Tissue Evaluation for a Novel Ultrashort Femtosecond Laser with Auto-Z Calibration. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5292.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Femtosecond laser has been used for creating LASIK flap, inlay channel, and other corneal incisions. To further advance the femtosecond technology, we evaluated a novel ultrashort femtosecond laser. The purpose here is to present the experimental results for flap and inlay channel incisions.

Methods : The novel ultrashort femtosecond laser was built with an ultrashort fiber laser, a high numerical aperture beam delivery, and an ultrafast scanning. The cutting depth is controlled with sub-micron precision using an innovative automatic glass interface detection device (Auto-Z). Over 200 ex-vivo pig eyes were used in the evaluation.

Results :
1-Flap thickness consistency: 9mm diameter flap with a targeted thickness of 80μm was performed on 50 pig eyes, with side cut energy=110nJ/pulse, bed cut energy=70nJ/pulse, and the cutting time was 8.7s. All flaps showed tissue-bridge free dissection and easy lift as evaluated by subject matter experts (SME). The achieved average thickness=81µm, the standard deviation=1.9µm comparing to 5–12µm for on-market products.
2-Flap cutting time: by increasing bed cut energy to 90nJ/pulse and accelerating scanning speed, 5.0 s cutting time was achieved. Tissue roughness of the flap was measured using a white light interferometer: mean roughness=1.6±0.7µm, RMS roughness=2.0±0.9µm (N=8), comparing to mean=2.6µm and RMS=3.2µm of a control flap cut with iFS Advanced Femtosecond Laser.
3-Flap bubble releasing: to ensure there is always a gas escape channel, the flap incision starts with the side cut, then a ring bed cut underneath the side cut, then the bed cut. Random gas bursts from the side cut was observed in flap incisions; no gas buildup inside the flap was observed (N=10).
4-Inlay channel: both standard and lollipop inlay channel patterns on pig eyes demonstrated uniform bubble patterns and ease of insertion for the Inlay disk with no significant adhesion judged by SME. Placement depth of the Inlay disk measured by an OCT was ±6µm of the intended depth of 200µm (N=10).

Conclusions : We have shown with preliminary pig eye results that the novel ultrashort femtosecond laser can create tissue-bridge free flap incisions and Inlay channels with superior thickness consistency, smooth tissue dissection, no gas buildup, and shortened cutting time. We plan to perform further experiments on cadaver eyes.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×