June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Clinical factors associated with dysbiosis of gut microbiota affects the risk of retinopathy of prematurity
Author Affiliations & Notes
  • YEONJI JANG
    Ophthalmology, Seoul national university Hospital, Seoul, Korea (the Republic of)
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Byung Joo Lee
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea (the Republic of)
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
  • Dong Hyun Jo
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea (the Republic of)
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
  • Seung Han Shin
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea, Seoul, Korea (the Republic of)
  • Ee-Kyung Kim
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea, Seoul, Korea (the Republic of)
  • Han-Suk Kim
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea, Seoul, Korea (the Republic of)
  • Young Suk Yu
    Ophthalmology, Seoul national university Hospital, Seoul, Korea (the Republic of)
  • Jeong Hun Kim
    Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea (the Republic of)
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   YEONJI JANG, None; Byung Joo Lee, None; Dong Hyun Jo, None; Seung Han Shin, None; Ee-Kyung Kim, None; Han-Suk Kim, None; Young Suk Yu, None; Jeong Hun Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5525. doi:
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      YEONJI JANG, Byung Joo Lee, Dong Hyun Jo, Seung Han Shin, Ee-Kyung Kim, Han-Suk Kim, Young Suk Yu, Jeong Hun Kim; Clinical factors associated with dysbiosis of gut microbiota affects the risk of retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5525.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the relationship between development of retinopathy of prematurity (ROP) and clinical factors that might cause dysbiosis of gut microbiota in premature infants.

Methods : Medical records were retrospectively reviewed in 173 patients who had admitted to the neonatal intensive care unit of Seoul National University Children’s Hospital from January 2010 to December 2011, had undergone ROP screening, and whose gestational age was less than 32 weeks or whose birth weight was less than 1500 g. Sex, gestational age, birth weight, presence of chorioamnionitis, maternal antibiotics use, delivery methods, systemic antibiotics use, total parenteral nutrition, and presence of leukocytosis were documented. Then, the relation between the development of ROP and these clinical factors were statistically analyzed using univariate analysis, multivariate analysis and logistic regression analysis.

Results : Of the 173 patients, 68 had ROP, and 30 of them had severe ROP. The incidence of ROP was significantly higher in patients with chorioamnionitis, systemic antibiotics use, total parenteral nutrition, and leukocytosis. Among them, chorioamnionitis and leukocytosis were identified to be risk factors for ROP independent of the previously reported ones such as gestational age or birth weight.

Conclusions : Several clinical factors related to dysbiosis of gut microbiota were found to correlate with the prevalence of ROP. These results are expected to be the basis for further studies to prevent the development of ROP through gut microbial regulation.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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