June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Laser versus Bevacizumab for Type-1 Retinopathy of Prematurity: long term effects of foveal dislocation on ocular alignment
Author Affiliations & Notes
  • Domenico Lepore
    Dept of Ophthalmology, Catholic University, Rome, Italy
  • Lorenzo Orazi
    IAPB ITALIA onlus , Italian National Center of services and Research for Prevention of Blindness and Rehabilitation of the Visually impaired, Rome, Italy
    Dept of Ophthalmology, Catholic University, Rome, Italy
  • Filippo Maria Amore
    IAPB ITALIA onlus , Italian National Center of services and Research for Prevention of Blindness and Rehabilitation of the Visually impaired, Rome, Italy
  • Daniela Ricci
    IAPB ITALIA onlus , Italian National Center of services and Research for Prevention of Blindness and Rehabilitation of the Visually impaired, Rome, Italy
  • Maria Petrianni
    IAPB ITALIA onlus , Italian National Center of services and Research for Prevention of Blindness and Rehabilitation of the Visually impaired, Rome, Italy
  • Antonio Baldascino
    Dept of Ophthalmology, Catholic University, Rome, Italy
  • Marco H Ji
    Dept of Ophthalmology, Catholic University, Rome, Italy
  • Fernando Molle
    Dept of Ophthalmology, Catholic University, Rome, Italy
  • Footnotes
    Commercial Relationships   Domenico Lepore, None; Lorenzo Orazi, None; Filippo Amore, None; Daniela Ricci, None; Maria Petrianni, None; Antonio Baldascino, None; Marco Ji, None; Fernando Molle, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5546. doi:
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      Domenico Lepore, Lorenzo Orazi, Filippo Maria Amore, Daniela Ricci, Maria Petrianni, Antonio Baldascino, Marco H Ji, Fernando Molle; Laser versus Bevacizumab for Type-1 Retinopathy of Prematurity: long term effects of foveal dislocation on ocular alignment. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5546.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate long term effects of foveal dislocation on ocular alignment in a single center randomized study aimed to compared traditional laser treatment for Type 1 retinopathy of prematurity (ROP) with intravitreal injection of bevacizumab in the fellow eye.

Methods : Twenty-one inborn babies with type 1 zone 1 ROP were included in the study. One eye was randomized to receive an intravitreal injection of 0.5mg bevacizumab; the fellow eye received conventional laser photoablation. Fundus color and fluorescein angiography Images from 32 eyes (16 infants) with type-1 ROP were obtained before 5 years after treatment. 5 babies were lost at follow up. Fovea was localized by three different readers using color image and FA and then its distance from the center of the optic disk measured in pixels. Complete ocular motility exam was performed. In case of strabismus angle of ocular deviation was measured in prismatic diopters by two different examiners. Cycloplegic refraction was also performed using automated refractometer.

Results : Eight babies showed 10 or more pixel of difference in the distance of the foveal to the optic disk between the two eyes: in all cases the foveal of the laser-treated eye was closer to the optic disk compared to the injected eye. Four babies showed a wide angle (up to 40 prismatic dioters) esotropia: all these babies were those ones that had the greater difference in the distance between fovea and optic disk. There was no significant difference in the refractive status of these babies eyes.

Conclusions : treatment seems to deeply affects macular development with a foveal dislocation toward the optic disk in the lasered eyes thus causing eyes misalignment. Further studies are need in order to understand how to manage this ocular misalignment.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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