June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Vitamin D in Systemic Sclerosis Patients with Dry Eye Syndrome
Author Affiliations & Notes
  • Caterina Gagliano
    Ophthalmology, NEST (Neurovisual Science Technology), Catania, Italy
    Rare Disease Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Rosario Foti
    Rheumatologic Unit, Catania University, Catania, Italy
    Rare Disease Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Elisa Visalli
    Rheumatologic Unit, Catania University, Catania, Italy
    Rare Disease Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Roberta Amato
    Ophthalmology, NEST (Neurovisual Science Technology), Catania, Italy
    Rare Disease Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Giuseppe Calì
    Eye Clinic, Catania University, Catania, Italy
    Rare Disease Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Giovanni Panta
    Eye Clinic, Santa Marta Hospital, Catania, Italy
    Rare Disease Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Daniela Rocca
    Eye Clinic, Santa Marta Hospital, Catania, Italy
    Rare Disease Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Alessandra Pizzo
    Eye Clinic, Catania University, Catania, Italy
    Rare Disease Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Giorgio Amato
    Rheumatologic Unit, Catania University, Catania, Italy
    Rare Disease Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Giulia Malaguarnera
    Ophthalmology, NEST (Neurovisual Science Technology), Catania, Italy
    Rare Disease Center (Ra.Di.Ce.), Santa Marta Hospital, Catania, Italy
  • Footnotes
    Commercial Relationships   Caterina Gagliano, None; Rosario Foti, None; Elisa Visalli, None; Roberta Amato, None; Giuseppe Calì, None; Giovanni Panta, None; Daniela Rocca, None; Alessandra Pizzo, None; Giorgio Amato, None; Giulia Malaguarnera, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5587. doi:
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    • Get Citation

      Caterina Gagliano, Rosario Foti, Elisa Visalli, Roberta Amato, Giuseppe Calì, Giovanni Panta, Daniela Rocca, Alessandra Pizzo, Giorgio Amato, Giulia Malaguarnera; Vitamin D in Systemic Sclerosis Patients with Dry Eye Syndrome. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5587.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The purpose of this study was to explore the clinical and pathogenic significance of vitamin D (25-hydroxyvitamin D) in systemic sclerosis (SSc) patients with dry eye syndrome (DES). The relationship between the severity of DES, SSc disease activity and levels of 25-hydroxyvitamin D was investigated.

Methods : In this cross-sectional study, 32 consecutive patients with SSc and DES were enrolled. We measured blood concentrations of 25-hydroxyvitamin D (25 OH D) and correlated the results with SSc disease activity calculated with modified Rodman Skin Score (mRSS), Tear osmolarity measurements (TearLab system), Tear Break-Up Time (TBUT) test, and Schirmer tests (type I and II).

Results : Levels of 25 OH D were decreased in all SSc patients with DES as compared to normal controls and the reduced levels of 25 OH D were stable over the observed period of 2 months. Levels of 25 OH D correlated inversely with mRSS score and tear osmolarity (r = 0.610, p < 0.001), positively correlated with Schirmer values, (r = -0.231, p = 0.045), and TBUT values (r = -0.325, p = 0.007) among all patients.

Conclusions : Our study demonstrated a high relationship with SSc disease acitivity, severity of DES and low levels of 25-hydroxyvitamin D.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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