June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
The Relationship between Donor Graft Characteristics and Visual Acuity Outcomes after Descemet Stripping Automated Endothelial Keratoplasty
Author Affiliations & Notes
  • Matthew Schear
    Ophthalmology, Hofstra Northwell Health, Great Neck, New York, United States
  • Carolyn Shih
    Ophthalmology, Hofstra Northwell Health, Great Neck, New York, United States
  • Lisa Rosen
    Biostatistics, Hofstra Northwell Health, Manhasset, New York, United States
  • Bennett Hong
    Ophthalmology, Hofstra Northwell Health, Great Neck, New York, United States
  • Katherine Chen
    Ophthalmology, Hofstra Northwell Health, Great Neck, New York, United States
  • David Nauheim
    Ophthalmology, Hofstra Northwell Health, Great Neck, New York, United States
  • Matthew Gorski
    Ophthalmology, Hofstra Northwell Health, Great Neck, New York, United States
  • Jules Winokur
    Ophthalmology, Hofstra Northwell Health, Great Neck, New York, United States
  • Anne Steiner
    Ophthalmology, Hofstra Northwell Health, Great Neck, New York, United States
  • Ira J Udell
    Ophthalmology, Hofstra Northwell Health, Great Neck, New York, United States
  • Footnotes
    Commercial Relationships   Matthew Schear, None; Carolyn Shih, None; Lisa Rosen, None; Bennett Hong, None; Katherine Chen, None; David Nauheim, None; Matthew Gorski, None; Jules Winokur, None; Anne Steiner, None; Ira Udell, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5667. doi:
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      Matthew Schear, Carolyn Shih, Lisa Rosen, Bennett Hong, Katherine Chen, David Nauheim, Matthew Gorski, Jules Winokur, Anne Steiner, Ira J Udell; The Relationship between Donor Graft Characteristics and Visual Acuity Outcomes after Descemet Stripping Automated Endothelial Keratoplasty. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5667.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine how visual acuity varies based on donor graft characteristics after Descemet Stripping Automated Endothelial Keratoplasty (DSAEK).

Methods : A retrospective chart review was performed on 209 eyes of 190 subjects that underwent DSAEK at the Hofstra Northwell Health Department of Ophthalmology. Patients whose vision may be limited by diagnoses such as advanced glaucoma or retinal pathology were not included. 14 subjects required a re-bubble and were included. Best corrected visual acuity was measured at pre-op, 3 months, 6 months and 1 year and converted to their LogMAR equivalents. Donor characteristics analyzed include donor age, death to preservation time, death to insertion time, post-cut central corneal thickness and post-cut endothelial cell count. A linear mixed model for repeated measures was used to model LogMAR over time as a function of each factor of interest.

Results : The mean subject age was 77.48 ± 11.70, 41.83% were male and the mean pre-op LogMAR was 0.96 ± 0.66. Of the donor grafts, the mean donor age (years) was 53.16 ± 13.17, the mean death to preservation time (hours) was 9.50 ± 3.44, the mean death to insertion time (days) was 4.28 ± 1.64, the mean post-cut central corneal thickness was 135.67 ± 33.69 and the mean post-cut endothelial cell count 2945.28 ± 261.89. Better postoperative LogMAR correlated with shorter death to insertion time (p = 0.0450), higher post-cut endothelial cell count (p = 0.0363) and younger donor age (p = 0.0257). There was no association between postoperative LogMAR and death to preservation time or post cut central corneal thickness.

Conclusions : Better visual acuity outcomes were associated with a younger donor age, shorter donor death to insertion time, and higher donor endothelial cell counts. Further studies are needed to determine best pre-op characteristics of potential corneal donors to better improve recipient outcomes.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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