June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Recurrent keratoconus in eyes after penetrating keratoplasty
Author Affiliations & Notes
  • Junko Yoshida
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Hiroshi Murata
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Rika Shirakawa
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Toshihiro Sakisaka
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Tetsuya Toyono
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Takashi Miyai
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Satoru Yamagami
    Nihon University, Tokyo, Japan
  • Tomohiko Usui
    Ophthalmology, The University of Tokyo, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Junko Yoshida, None; Hiroshi Murata, None; Rika Shirakawa, None; Toshihiro Sakisaka, None; Tetsuya Toyono, None; Takashi Miyai, None; Satoru Yamagami, None; Tomohiko Usui, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5690. doi:
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      Junko Yoshida, Hiroshi Murata, Rika Shirakawa, Toshihiro Sakisaka, Tetsuya Toyono, Takashi Miyai, Satoru Yamagami, Tomohiko Usui; Recurrent keratoconus in eyes after penetrating keratoplasty. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5690.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To analyze the frequency and the backgrounds of recurrent keratonocus after penetrating keratoplasty (PK) in long term observation.

Methods : Retrospective chart review was performed on patients who visited the Cornea Clinic of the Department of Ophthalmology at the University of Tokyo Hospital from December 2015 to February 2016. The patients were extracted who maintained clear grafts for more than 10 years after PK. Patients were divided into 2 group, keratoconus (KCN) group and others, depending on their primary diseases for PK. Among those patients, statistical analysis was performed on whom received the corneal topography (TMS, TOMEY) several times 5 years after PK.

Results : One-hundred and one eyes in 82 patients were enrolled. KCN group included 50 eyes of KCN and others group 51 (Herpes 22, corneal leucoma 12, others 17 eyes). The average period after PK when reviewed was 26.6 (range 11-51) years. Graft extrusion after PK was observed in 18 eyes of 14 patients and all of them were of KCN group (p=0.0001). Three eyes in 3 patients showed the acute-hydrops-like findings such as corneal edema following ruptures of Descemet’s membrane and stroma. Four eyes in 4 patients received the secondary PK. The mean TMS Ks (maximum corneal power) during the whole observation periods was 52.5 diopters (D) in KCN group and 49.2 D in others (p<0.0001).

Conclusions : Recurrent keratoconus after PK was observed in 36% patients during the long time course in KCN patients, while none in others. The results indicate that KCN can progress on donor grafts.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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