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Chiara Ancona, Paola Cirafici, Serena Telani, Alessandro Masala, Carlo Enrico Traverso, Michele M Iester; Comparison between 24-2 and 10-2 visual fields and optical coherence tomography measurements in open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5815.
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© ARVO (1962-2015); The Authors (2016-present)
We performed a retrospective, observational clinical study to assess the correlation between visual field defects and retinal nerve fiber layer thickness in glaucoma patients.
Twenty-four glaucoma patients (9 females and 15 males) mean age (71.25 ± 7.59) were enrolled in our retrospective study and examined at Clinica Oculistica, University of Genoa.The examination included best correct visual acuity, intraocular pressure, Humphrey 24-2 and 10-2 visual field (VF), retinal nerve fiber layer (RFNL) and ganglion cell complex (GCC) by spectral domain optical coherence tomography (SD-OCT). RNFL and GCC thickness were compared with mean deviation (MD) and pattern standard deviation (PSD) in both 24-2 and 10-2 VF.The relationship between MD, PSD and OCT measurements was evaluated by Pearson's r correlation coefficient and linear regression model was applied to the data to evaluate the more predictive correlation. Significance was set at p< 0.05.
24-2 visual field MD (MD-24) showed a significant correlation with GCC (r= 0.5, p< 0.001) and with RNFL (r= 0.34, p< 0.05). 10-2 visual field MD (MD-10) showed a significant correlation with GCC (r= 0.61, p< 0.001) and RNFL (r=0.33, p< 0.05). 24-2 visual field PSD showed a significant correlation with GCC (r= -0.3 p< 0.05) but no significant correlation with RNFL (r= -0.21). 10-2 visual field PSD showed a significant correlation with GCC (r=-0.57 p< 0.001) and RNFL (r= -0.34, p< 0.05). A linear regression model found that GCC was the best predictor of MD-10 (Beta=0.582, p< 0.001).
Both MD-10 and MD-24 showed a significance correlation with GCC and RNFL but GCC was better correlated to MD-10 than the MD-24.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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