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Paola Cirafici, Chiara Ancona, Alessandro Masala, Serena Telani, Carlo Enrico Traverso, Michele M Iester; Sectorial structural/function correlation of OCT in 10-2 and 24-2 visual fields. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5816.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the relationship between sectorial spectral domain optical coherence tomography (SD-OCT) parameter thickness and the corresponding visual field (VF) area in in glaucoma patients.
Forty-eight eyes of open angle glaucoma patients were evaluated at the University Eye Clinic of Genoa and included in this retrospective, observational clinical study. All participants underwent a comprehensive ophthalmic examination, including best correct visual acuity, Humphrey 10-2 and 24-2 VF, and macular and peripapillary retinal nerve fiber layer (RNFL) thickness by SD-OCT RTvue-100 Optovue. Then ganglion cell complex (GCC) thickness, full retinal (FR) thickness, outer retinal (OR) thickness were considered and each parameter was divided into two sectors, superior and inferior, while from the sensitivity values of each point tested of both 10-2 and 24-2 VF maps, new clusters were calculated and the VF sensitivity values obtained were correlated to the corresponding area of the optic nerve head. Pearson's r correlation coefficient was applied to the data to evaluate the more predictive values. Significance was set at p< 0.05.
Average GCC had significant correlation to the central cluster of the both 24-2 (r=0.491, p<0.001) and 10-2 VF (r=0.470, p<0.001); furthermore a significant correlation was found between superior GCC and inferior cluster of VF in 24-2 (p<0.001) and in 10-2 VF (r=0.597, p<0.001)and between inferior GCC and superior cluster of VF both in 24-2 (p<0.001) and in 10-2 VF (r=0.581, p<0.001).FR thickness had significant correlation with central 24-2 (r=0.491, p<0.001) and 10-2 VF (r=0.470, p<0.001). Significant correlation was found between superior FR thickness and inferior cluster of VF both in 24-2 (p<0.001) and in 10-2 VF (r=0.561, p<0.001) and between inferior FR thickness and superior cluster of VF both in 24-2 (p<0.001) and in 10-2 VF (r=0.602, p<0.001).Outer retinal thickness showed no significant correlation with both 24-2 and 10-2 VF, while RNFL showed a weaker correlation to 24-2 and 10-2 VF cluster areas.
Global GCC and FR parameters were significantly correlated to central sensitivity of VF. Superior OCT sectors were better correlated to inferior part of the VF. RNFL had weaker correlation to VF than the other OCT parameters.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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