June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Open-angle glaucoma patients of African descent have more functional progression after 4 years compared to European descent patients while demonstrating similar structural progression
Author Affiliations & Notes
  • Priyanka Kanakamedala
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
  • Tyler Knight
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Aaditya Shah
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Christian P. Jonescu-Cuypers
    Neurosciences Cliniques, Ophthalmology, Hôpitaux Universitaires de Genève, Genève, Switzerland
  • Noa Geffen
    Department of Ophthalmology, Tel-Aviv University, Kfar-Saba, Israel
  • Josh C Gross
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Priyanka Kanakamedala, None; Alon Harris, AdOM (C), AdOM (I), Biolight (C), Isarna Therapeutics (C), Nano Retina (C), Nano Retina (I), Ono Pharmaceuticals (C), Oxymap (I), Science Based Health (C), Stemnion Inc. (C); Brent Siesky, None; Alice Chandra Verticchio Vercellin, None; Tyler Knight, None; Aaditya Shah, None; Christian Jonescu-Cuypers, None; Noa Geffen, AdOM Ltd (I), IOPtima (C); Josh Gross, None
  • Footnotes
    Support  NIH Grant 1R21EY022101-01A1, Research to Prevent Blindness NY, NY
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5839. doi:
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      Priyanka Kanakamedala, Alon Harris, Brent A Siesky, Alice Chandra Verticchio Vercellin, Tyler Knight, Aaditya Shah, Christian P. Jonescu-Cuypers, Noa Geffen, Josh C Gross; Open-angle glaucoma patients of African descent have more functional progression after 4 years compared to European descent patients while demonstrating similar structural progression. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5839.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine differences in relationships between structural and functional progression in open-angle glaucoma (OAG) patients of African descent (AD) and European descent (ED) after 4 years.

Methods : 112 patients with OAG (AD-29; ED-83) were assessed at baseline and every 6 months for 4 years for functional progression by 24-2 Swedish interactive threshold algorithm visual field (VF) (Humphrey), and for structural progression by optical coherence tomography. Functional progression was defined as 2 consecutive visits with mean deviation decrease ≥2 and/or advanced glaucoma intervention study (AGIS) increase ≥2 compared to baseline. Structural progression was defined as two consecutive visits with RNFL thickness decrease by at least 8% and/or horizontal or vertical cup/disk ratio increase by at least 0.2 compared to baseline.

Results : Baseline IOP (mmHg) for patients of AD was 16.85 (95% CI=14.92, 18.78) and was 15.64 (14.21, 17.07) for ED, with no significant difference between groups. Functional progression occurred in 37.93% of patients of AD (11 of 29) and 28.91% of patients of ED (24 of 83). Structural progression occurred in 62.09% of patients of AD (18 of 29) and 68.67% of patients of ED (57 of 83). Overall, significantly more (p<0.05) patients exhibited structural progression compared to functional progression; with no significant difference between groups (p>0.05).

Conclusions : Functional progression occurred more frequently in OAG patients of AD compared to ED despite similar baseline IOP. In all patients, structural progression occurred significantly more than functional progression.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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