June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Baseline structural parameters are predictive of shorter time to functional progression in open angle glaucoma patients after 5 years
Author Affiliations & Notes
  • Mary Runkle
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
  • Josh C Gross
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Colin Ridenour
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Ingrida Januleviciene
    Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Darrell WuDunn
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Mary Runkle, None; Alon Harris, AdOM (C), AdOM (I), Biolight (C), Isarna Therapeutics (C), Nano Retina (C), Nano Retina (I), Ono Pharmaceuticals (C), Oxymap (I), Science Based Health (C), Stemnion Inc. (C); Alice Chandra Verticchio Vercellin, None; Josh Gross, None; Colin Ridenour, None; Ingrida Januleviciene, Alcon (C), Alcon (R), Allergan (C), Allergan (R), Origmed (C), Origmed (R), Santen (C), Santen (R), Vittamed (C), Vittamed (R); Darrell WuDunn, Aerie Pharmaceuticals (F), Allergan (F), Bausch and Lomb (F), InnFocus (F), Mati Therapeutics (F), Ocular Therapeutics (F); Brent Siesky, None
  • Footnotes
    Support  Research to Prevent Blindness NY, NY
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5840. doi:
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      Mary Runkle, Alon Harris, Alice Chandra Verticchio Vercellin, Josh C Gross, Colin Ridenour, Ingrida Januleviciene, Darrell WuDunn, Brent A Siesky; Baseline structural parameters are predictive of shorter time to functional progression in open angle glaucoma patients after 5 years. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5840.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the relationships between baseline structural parameters and functional progression in open angle glaucoma (OAG) patients after 5 years.

Methods : 111 OAG patients (mean age 65 yrs; 44 male) were assessed at baseline for optic nerve head morphology by Heidelberg retinal tomography 3 (HRT3). Functional progression was evaluated every 6 months for 5 years by 24-2 Swedish interactive threshold algorithm visual field (VF) (Humphrey). Progression was defined as 2 consecutive visits with mean deviation decrease by at least 2 compared to baseline and/or advanced glaucoma intervention study (AGIS) increase by at least 2 compared to baseline. Mixed-model ANCOVA was used to test for statistically significance changes from baseline to 5-year follow-up. Time to functional progression was analyzed using Cox proportional hazards survival analysis.

Results : Statistically significant shorter time to functional progression was associated with higher baseline cup area 0.870 (95% CI=0.735, 1.015), cup/disc area ratio 0.410 (0.359, 0.461), linear cup/disc ratio 0.619 (0.573, 0.665), cup shape -0.128 (-0.149, -0.108), and lower baseline rim area 1.268 (1.159, 1.377), rim volume 0.295 (0.246, 0.344), height variation contour 0.330 (0.297, 0.366), mean RNFL thickness 0.196 (0.172, 0.219), and RNFL cross-sectional area 1.025 (0.901, 1.148) (all p<0.05).

Conclusions : In OAG patients, baseline optic nerve head and retinal structural parameters were predictive of shorter time to functional progression after 5 years.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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