June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Changes in visual function are more strongly correlated with changes in optic nerve head morphology in open angle glaucoma patients with diabetes mellitus over 4 years
Author Affiliations & Notes
  • Nathaniel Kim
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
  • Josh C Gross
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Colin Ridenour
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Aditya Belamkar
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Darrell WuDunn
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Nathaniel Kim, None; Alon Harris, AdOM (C), AdOM (I), Biolight (C), Isarna Therapeutics (C), Nano Retina (C), Nano Retina (I), Ono Pharmaceuticals (C), Oxymap (I), ScienceBased Health (C), Stemnion (C); Alice Chandra Verticchio Vercellin, None; Josh Gross, None; Colin Ridenour, None; Aditya Belamkar, None; Darrell WuDunn, Aerie Pharmaceuticals (F), Allergan (F), Bausch and Lomb (F), InnFocus (F), Mati Therapeutics (F), Ocular Therapeutics (F); Brent Siesky, None
  • Footnotes
    Support  American Diabetes Association Grant 1-12-IN-20; Research to Prevent Blindness NY, NY
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5842. doi:
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      Nathaniel Kim, Alon Harris, Alice Chandra Verticchio Vercellin, Josh C Gross, Colin Ridenour, Aditya Belamkar, Darrell WuDunn, Brent A Siesky; Changes in visual function are more strongly correlated with changes in optic nerve head morphology in open angle glaucoma patients with diabetes mellitus over 4 years. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5842.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the relationship between changes in visual function and changes in optic nerve head (ONH) morphology in open angle glaucoma (OAG) patients with and without diabetes mellitus (DM) over 4 years.

Methods : 85 patients with OAG (16 with DM, 69 without DM) were assessed for visual function by 24-2 Swedish interactive threshold algorithm visual field (VF) (Humphrey), and ONH morphology was assessed by Heidelberg retinal tomography 3 (HRT3) every 6 months over a 4-year period. Pearson correlations were used to test for associations between measurements over time with p<0.05 considered statistically significant.

Results : In OAG patients with DM, changes in VF mean deviation (MD) were positively and significantly associated with glaucomatous changes in rim area (r=0.58, p<0.02) and RNFL cross sectional area (r=0.65, p<0.01), and negatively and significantly associated with cup area (r=-0.58, p<0.02), cup volume (r=-0.83, p<0.00), cup depth (r=-0.76, p<0.00), and max cup depth (r=-0.54, p<0.03). In non-DM patients, these relationships were weakly correlated and significantly different compared to OAG patients with DM (all comparisons p<0.05).

Conclusions : In OAG patients with DM, changes in visual function more strongly correlate with changes in ONH morphology compared to non-DM OAG patients after 4 years.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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