June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Customizable, programmable, multimodal ophthalmic laser platform: towards improved therapy
Author Affiliations & Notes
  • Suzie Dufour
    Biophotonics, National Institute of Optics, Quebec, Quebec, Canada
  • Robert B Brown
    Biophotonics, National Institute of Optics, Quebec, Quebec, Canada
  • Sébastien Jean Méthot
    Département d’Ophtalmologie et ORL, Université Laval , Quebec, Quebec, Canada
    Hôpital du Saint-Sacrement, Centre de Recherche du CHU de Québec, Quebec, Quebec, Canada
  • Pascal Gallant
    Biophotonics, National Institute of Optics, Quebec, Quebec, Canada
  • Patrick J Rochette
    Département d’Ophtalmologie et ORL, Université Laval , Quebec, Quebec, Canada
    Hôpital du Saint-Sacrement, Centre de Recherche du CHU de Québec, Quebec, Quebec, Canada
  • Ozzy Mermut
    Biophotonics, National Institute of Optics, Quebec, Quebec, Canada
  • Footnotes
    Commercial Relationships   Suzie Dufour, None; Robert Brown, None; Sébastien Méthot, None; Pascal Gallant, None; Patrick Rochette, None; Ozzy Mermut, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5985. doi:
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      Suzie Dufour, Robert B Brown, Sébastien Jean Méthot, Pascal Gallant, Patrick J Rochette, Ozzy Mermut; Customizable, programmable, multimodal ophthalmic laser platform: towards improved therapy. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5985.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : In retinal laser treatments, poor thermal damage confinement can lead to undesirable photoreceptors damage and affect patient visual functions. Additionally, consistent dosing of energy is challenging due to tissue inhomogeneity. The objective of this work is to develop a novel phototerapeutic platform to improve control over photo-thermal and mechanical dammage as well as photoacoustic feedback/dosimetry in retinal treatments. The system takes advantage of a tunable energy deposition rate which provides a better control on its impact on tissue.

Methods : The system uses a programmable fiber laser (532 nm). Different pulse shapes from 3 ns to 1.6 us in length were programmed. Effects of these shapes on cells and photoacoustic (PA) feedback were evaluated.Experiments were conducted on custom photoacoustic (PA) phantom and retinal pigment epithelium (RPE) explants. Explants were prepared from fresh adult rabbit eyes, in accordance with the ARVO Animal Statement and our institution’s guidelines.

Results : In our previous work, we found that the threshold for cavitation is 30% higher for a Q-switch-like impulsion shape than it is for a ramp shape. We also compared the microbubble size at twice the cavitation threshold and found that the averaged radius of evoked cavitations was 25% larger for Q-switch-like than for ramp shape. In this preliminary study, 395 trials on 15 RPE sheet samples from 5 different subjects were performed. In average, we found a damage thresholds of 170 ± 27 and 150 ± 25 mJ/mm2 for ramp and Q-switch-like shapes respectively. Additionally, we report that modulating laser pulses help optimize the signal-to-noise ration of the PA wave generated. This demonstrate the potential for real-time treatment feedback and dosimetry.

Conclusions : To conclude, both treatment and PA monitoring can benefit from the pulse formatting capabilities of programmable fiber lasers. This lead to a customizable, programmable multimodal ophthalmic laser platform.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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