Volume 51 Issue 8 | IOVS

Anatomy and Pathology/Oncology

Changes in Fibroblast Mechanostat Set Point and Mechanosensitivity: An Adaptive Response to Mechanical Stress in Floppy Eyelid Syndrome Free

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Daniel G. Ezra; James S. Ellis; Michèle Beaconsfield; Richard Collin; Maryse Bailly

Tags: fibroblasts, floppy lid syndrome, stress, mechanical, collagen, gel

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3853-3863. doi:https://doi.org/10.1167/iovs.09-4724

Effects of Optical Defocus on Refractive Development in Monkeys: Evidence for Local, Regionally Selective Mechanisms Free

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Earl L. Smith, III; Li-Fang Hung; Juan Huang; Terry L. Blasdel; Tammy L. Humbird; Kurt H. Bockhorst

Tags: cercopithecidae, eye, lens (device), lens, crystalline, optics

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3864-3873. doi:https://doi.org/10.1167/iovs.09-4969

Differential Role of Tumor Necrosis Factor (TNF)-α Receptors in the Development of Choroidal Neovascularization Free

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Monika Jasielska; Irina Semkova; Xuan Shi; Kristina Schmidt; Dimitrios Karagiannis; Despina Kokkinou; Jerzy Mackiewicz; Norbert Kociok; Antonia M. Joussen

Tags: choroidal neovascularization, lasers, mice, tumor necrosis factors, macrophages

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3874-3883. doi:https://doi.org/10.1167/iovs.09-5003

Biochemistry and Molecular Biology

Variable Retinal Phenotypes Caused by Mutations in the X-Linked Photopigment Gene Array Free

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Liliana Mizrahi-Meissonnier; Saul Merin; Eyal Banin; Dror Sharon

Tags: dna microarrays, genes, mutation, opsin, phenotype

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3884-3892. doi:https://doi.org/10.1167/iovs.09-4592

Pathway-Focused Arrays Reveal Increased Matrix Metalloproteinase-7 (Matrilysin) Transcription in Trachomatous Trichiasis Free

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Martin J. Holland; David Jeffries; Michael Pattison; Gerit Korr; Alevtina Gall; Hassan Joof; Ahmed Manjang; Matthew J. Burton; David C. W. Mabey; Robin L. Bailey

Tags: conjunctiva, eyelid trichiasis, genes, matrilysin, proteins

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3893-3902. doi:https://doi.org/10.1167/iovs.09-5054

Clinical and Epidemiologic Research

Use of Single-Vision Distance Spectacles Improves Landing Control during Step Descent in Well-Adapted Multifocal Lens-Wearers Free

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Matthew A. Timmis; Louise Johnson; David B. Elliott; John G. Buckley

Tags: eyeglasses, lens (device), lens, crystalline, vision

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3903-3908. doi:https://doi.org/10.1167/iovs.09-4987

The Use of Best Visual Acuity over Several Encounters as an Outcome Variable: An Analysis of Systematic Bias Free

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Dara Koozekanani; Douglas J. Covert; David V. Weinberg

Tags: outcome variable, visual acuity

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3909-3912. doi:https://doi.org/10.1167/iovs.09-4643

Macular Thickness Variations with Sex, Age, and Axial Length in Healthy Subjects: A Spectral Domain–Optical Coherence Tomography Study Free

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Won Kyung Song; Sung Chul Lee; Eun Suk Lee; Chan Yun Kim; Sung Soo Kim

Tags: optical coherence tomography, refractive errors, volume, correlation studies

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3913-3918. doi:https://doi.org/10.1167/iovs.09-4189

The Differential Effect of Ultraviolet Light Exposure on Cataract Rate across Regions of the Lens Free

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Alison G. Abraham; Christopher Cox; Sheila West

Tags: cataract, lens (device), lens, crystalline, ultraviolet rays, cortical cataract

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3919-3923. doi:https://doi.org/10.1167/iovs.09-4557

The Association between Copy Number Variations in Glutathione S-transferase M1 and T1 and Age-Related Cataract in a Han Chinese Population Free

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Jing Zhou; Jianyan Hu; Huaijin Guan

Tags: cataract, senile, chinese (other dialects), chinese people, copy number polymorphism, glutathione

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3924-3928. doi:https://doi.org/10.1167/iovs.10-5240

Cornea

Influence of Corneal Collagen Crosslinking with Riboflavin and Ultraviolet-A Irradiation on Excimer Laser Surgery Free

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Daniel Kampik; Bernhard Ralla; Sabine Keller; Markus Hirschberg; Peter Friedl; Gerd Geerling

Tags: cornea, corneal collagen cross-linking, excimer lasers, riboflavin, surgical procedures, operative

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3929-3934. doi:https://doi.org/10.1167/iovs.09-4524

Role of Insulin in Regulation of Na⁺-/K⁺-Dependent ATPase Activity and Pump Function in Corneal Endothelial Cells Free

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Shin Hatou; Masakazu Yamada; Yoko Akune; Hiroshi Mochizuki; Atsushi Shiraishi; Takeshi Joko; Teruo Nishida; Kazuo Tsubota

Tags: adenosine triphosphatases, cornea, endothelial cells, insulin

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3935-3942. doi:https://doi.org/10.1167/iovs.09-4027

A Hierarchy of Endothelial Colony–Forming Cell Activity Displayed by Bovine Corneal Endothelial Cells Free

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Lan Huang; Matthew Harkenrider; Meredith Thompson; Pingyu Zeng; Hiromi Tanaka; David Gilley; David A. Ingram; Joseph A. Bonanno; Mervin C. Yoder

Tags: cattle, cornea, electroconvulsive therapy, endothelial cells, endothelium

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3943-3949. doi:https://doi.org/10.1167/iovs.09-4970

In Vitro Efficacy of Antifungal Treatment Using Riboflavin/UV-A (365 nm) Combination and Amphotericin B Free

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Arnaud Sauer; Valérie Letscher-Bru; Claude Speeg-Schatz; David Touboul; Joseph Colin; Ermanno Candolfi; Tristan Bourcier

Tags: amphotericin b, antifungal agents, riboflavin, ultraviolet a radiation

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3950-3953. doi:https://doi.org/10.1167/iovs.09-4013

Inhibition by Tranilast of the Cytokine-Induced Expression of Chemokines and the Adhesion Molecule VCAM-1 in Human Corneal Fibroblasts Free

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Tadafumi Adachi; Ken Fukuda; Yukiko Kondo; Teruo Nishida

Tags: cell adhesion molecules, chemokines, cornea, cytokine, fibroblasts

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3954-3960. doi:https://doi.org/10.1167/iovs.09-4161

Corneal Biomechanical Changes after Collagen Cross-Linking from Porcine Eye Inflation Experiments Free

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Sabine Kling; Laura Remon; Alfonso Pérez-Escudero; Jesus Merayo-Lloves; Susana Marcos

Tags: cornea, corneal collagen cross-linking, eye, suidae, economic inflation

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3961-3968. doi:https://doi.org/10.1167/iovs.09-4536

Cold-Sensitive Corneal Afferents Respond to a Variety of Ocular Stimuli Central to Tear Production: Implications for Dry Eye Disease Free

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Harumitsu Hirata; Ian D. Meng

Tags: cold sensation, cold temperature, common cold, cornea, dry eye syndromes

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3969-3976. doi:https://doi.org/10.1167/iovs.09-4744

C-Terminal Cleavage of ΔNp63α Is Associated with TSA-Induced Apoptosis in Immortalized Corneal Epithelial Cells Free

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Danielle M. Robertson; Su-Inn Ho; H. Dwight Cavanagh

Tags: apoptosis, caspases, corneal epithelial cells, cytokinesis, protein isoforms

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3977-3985. doi:https://doi.org/10.1167/iovs.09-4919

In Vivo Evaluation of Superior Limbic Keratoconjunctivitis Using Laser Scanning Confocal Microscopy and Conjunctival Impression Cytology Free

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Takashi Kojima; Yukihiro Matsumoto; Osama M. A. Ibrahim; Enrique Adan Sato; Murat Dogru; Kazuo Tsubota

Tags: conjunctiva, cytology, microscopy, confocal, microscopy, confocal scanning laser, superior limbic keratoconjunctivitis

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3986-3992. doi:https://doi.org/10.1167/iovs.09-4932

Culture, Immortalization, and Characterization of Human Meibomian Gland Epithelial Cells Free

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Shaohui Liu; Mark P. Hatton; Payal Khandelwal; David A. Sullivan

Tags: epithelial cells, meibomian gland

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3993-4005. doi:https://doi.org/10.1167/iovs.09-5108

Linkage of Posterior Amorphous Corneal Dystrophy to Chromosome 12q21.33 and Exclusion of Coding Region Mutations in KERA, LUM, DCN, and EPYC Free

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Anthony J. Aldave; George O. D. Rosenwasser; Vivek S. Yellore; Jeanette C. Papp; Eric M. Sobel; Michele N. Pham; Michael C. Chen; Sugandha Dandekar; Ram Sripracha; Sylvia A. Rayner; Joseph W. Sassani; Michael B. Gorin

Tags: chromosomes, dna, genetic linkage analysis, hereditary corneal dystrophy, mutation

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4006-4012. doi:https://doi.org/10.1167/iovs.09-4067

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Correlation of Relative Afferent Pupillary Defect and Retinal Nerve Fiber Layer Loss in Unilateral or Asymmetric Demyelinating Optic Neuropathy Free

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Amjad A. Younis; Eric R. Eggenberger

Tags: optic nerve disorders, relative afferent pupillary defect, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4013-4016. doi:https://doi.org/10.1167/iovs.09-4644

The Relationship between Phoria and the Ratio of Convergence Peak Velocity to Divergence Peak Velocity Free

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Eun H. Kim; Bérangère Granger-Donetti; Vincent R. Vicci; Tara L. Alvarez

Tags: strabismus, velocity

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4017-4027. doi:https://doi.org/10.1167/iovs.09-4560

Immunolocalization of Gap Junction Protein Connexin43 (GJA1) in the Human Retina and Optic Nerve Free

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Nathan M. Kerr; Cameron S. Johnson; Clairton F. de Souza; Kaa-Sandra Chee; William R. Good; Colin R. Green; Helen V. Danesh-Meyer

Tags: connexin 43, gap junction protein, optic nerve, retina

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4028-4034. doi:https://doi.org/10.1167/iovs.09-4847

Fixation-Free Assessment of the Hirschberg Ratio Free

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Dmitri Model; Moshe Eizenman; Veit Sturm

Tags: adult, corneal reflexes, eye, folr1 gene, fresh-frozen plasma

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4035-4039. doi:https://doi.org/10.1167/iovs.09-5014

Glaucoma

Dynamic Analysis of Iris Configuration with Anterior Segment Optical Coherence Tomography Free

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Carol Yim-lui Cheung; Shu Liu; Robert N. Weinreb; Jing Liu; Haitao Li; Dexter Yu-lung Leung; Syril Dorairaj; Jeffrey Liebmann; Robert Ritch; Dennis Shun Chiu Lam; Christopher Kai-shun Leung

Tags: genu varum, immune reconstitution inflammatory syndrome, iris, optical coherence tomography, pupil

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4040-4046. doi:https://doi.org/10.1167/iovs.09-3941

Surface Topographies of Glaucoma Drainage Devices and Their Influence on Human Tenon Fibroblast Adhesion Free

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Lars Choritz; Kaloian Koynov; Giulia Renieri; Keith Barton; Norbert Pfeiffer; Hagen Thieme

Tags: adhesions, bone plates, fibroblasts, glaucoma drainage implants, implants

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4047-4053. doi:https://doi.org/10.1167/iovs.09-4759

Identification and Assessment of Schlemm's Canal by Spectral-Domain Optical Coherence Tomography Free

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Larry Kagemann; Gadi Wollstein; Hiroshi Ishikawa; Richard A. Bilonick; Peter M. Brennen; Lindsey S. Folio; Michelle L. Gabriele; Joel S. Schuman

Tags: diagnostic imaging, eye, glaucoma, optical coherence tomography, schlemm's canal

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4054-4059. doi:https://doi.org/10.1167/iovs.09-4559

Morphologic Changes in the Outflow Pathways of Bovine Eyes Treated with Corticosteroids Free

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Ozan-Yüksel Tektas; Christian Manfred Hammer; John Danias; Oscar Candia; Rosana Gerometta; Steven M. Podos; Elke Lütjen-Drecoll

Tags: cattle, eye, glucocorticoids, adrenal corticosteroids, mineralocorticoids

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4060-4066. doi:https://doi.org/10.1167/iovs.09-4742

Adjusted Peripapillary Retinal Nerve Fiber Layer Thickness Measurements Based on the Optic Nerve Head Scan Angle Free

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Samin Hong; Chan Yun Kim; Gong Je Seong

Tags: optic disk, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4067-4074. doi:https://doi.org/10.1167/iovs.09-4301

Effect of Myopia on the Thickness of the Retinal Nerve Fiber Layer Measured by Cirrus HD Optical Coherence Tomography Free

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Shin Hee Kang; Seung Woo Hong; Seong Kyu Im; Sang Hyup Lee; Myung Douk Ahn

Tags: myopia, optical coherence tomography, retinal nerve fiber layer, magnification, eye

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4075-4083. doi:https://doi.org/10.1167/iovs.09-4737

Global Gene Expression Changes in Rat Retinal Ganglion Cells in Experimental Glaucoma Free

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Dan Yi Wang; Arjun Ray; Kathryn Rodgers; Ceren Ergorul; Bradley T. Hyman; Wei Huang; Cynthia L. Grosskreutz

Tags: gene expression, genes, glaucoma, retinal ganglion cells, intraocular pressure

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4084-4095. doi:https://doi.org/10.1167/iovs.09-4864

Modulation of Factors Affecting Optic Nerve Head Astrocyte Migration Free

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Haixi Miao; Andrea W. Crabb; M. Rosario Hernandez; Thomas J. Lukas

Tags: astrocytes, myosin light chain kinase, optic disk

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4096-4103. doi:https://doi.org/10.1167/iovs.10-5177

Effect of Disease Severity on the Performance of Cirrus Spectral-Domain OCT for Glaucoma Diagnosis Free

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Mauro T. Leite; Linda M. Zangwill; Robert N. Weinreb; Harsha L. Rao; Luciana M. Alencar; Pamela A. Sample; Felipe A. Medeiros

Tags: glaucoma, severity of illness

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4104-4109. doi:https://doi.org/10.1167/iovs.09-4716

Association of Polymorphisms of Tumor Necrosis Factor and Tumor Protein p53 with Primary Open-Angle Glaucoma Free

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Bao Jian Fan; Ke Liu; Dan Yi Wang; Clement C. Y. Tham; Pancy O. S. Tam; Dennis S. C. Lam; Chi Pui Pang

Tags: open-angle glaucoma, protein p53, tp53 gene, tumor necrosis factors, genes

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4110-4116. doi:https://doi.org/10.1167/iovs.09-4974

Effects of Topical Phenylephrine and Tafluprost on Optic Nerve Head Circulation in Monkeys with Unilateral Experimental Glaucoma Free

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Chihiro Mayama; Kiyoshi Ishii; Tadashiro Saeki; Takashi Ota; Atsuo Tomidokoro; Makoto Araie

Tags: cercopithecidae, glaucoma, optic disk, phenylephrine, tafluprost

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4117-4124. doi:https://doi.org/10.1167/iovs.10-5218

Immunology and Microbiology

Experimental Intracameral Injection of Vancomycin Microparticles in Rabbits Free

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Laurent Kodjikian; Jérémy Couprie; Walid Hachicha; Quadiri Timour; Mojgan Devouassoux; Nicolas Builles; Daniel Hartmann; Hatem Fessi

Tags: vancomycin, oryctolagus cuniculus, cell-derived microparticles

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4125-4132. doi:https://doi.org/10.1167/iovs.09-4694

Cytokine Polymorphism in Noninfectious Uveitis Free

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Denize Atan; Samantha Fraser-Bell; Jarka Plskova; Lucia Kuffova; Aideen Hogan; Adnan Tufail; Dara J. Kilmartin; John V. Forrester; Jeff Bidwell; Andrew D. Dick; Amanda J. Churchill

Tags: cytokine, interleukin-10, polymorphism, uveitis, tumor necrosis factors

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4133-4142. doi:https://doi.org/10.1167/iovs.09-4583

Chemokine Levels in Subretinal Fluid Obtained during Scleral Buckling Surgery after Rhegmatogenous Retinal Detachment Free

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Lukas J. A. G. Ricker; Aize Kijlstra; Wilco de Jager; Albert T. A. Liem; Fred Hendrikse; Ellen C. La Heij

Tags: chemokines, rhegmatogenous retinal detachment, scleral buckling, surgical procedures, operative, radiation recall dermatitis

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4143-4150. doi:https://doi.org/10.1167/iovs.09-5057

An In Vitro Investigation of Synergy or Antagonism between Antimicrobial Combinations against Isolates from Bacterial Keratitis Free

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Henri Sueke; Stephen B. Kaye; Timothy Neal; Amanda Hall; Stephen Tuft; Christopher M. Parry

Tags: antimicrobials, bacterial keratitis

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4151-4155. doi:https://doi.org/10.1167/iovs.09-4839

Lens

Purinergic Receptors in the Rat Lens: Activation of P2X Receptors following Hyperosmotic Stress Free

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Haruna Suzuki-Kerr; Julie C. Lim; Paul J. Donaldson

Tags: lens (device), lens, crystalline, receptors, purinergic p2x, stress, purinoceptor

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4156-4163. doi:https://doi.org/10.1167/iovs.09-5023

Ubiquitin Proteasome Pathway–Mediated Degradation of Proteins: Effects Due to Site-Specific Substrate Deamidation Free

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Edward J. Dudek; Kirsten J. Lampi; Jason A. Lampi; Fu Shang; Jonathan King; Yongting Wang; Allen Taylor

Tags: catabolism, crystallins, proteins, ubiquitin, ubiquitination

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4164-4173. doi:https://doi.org/10.1167/iovs.09-4087

Physiology and Pharmacology

Nimodipine Enhancement of α2 Adrenergic Modulation of NMDA Receptor via a Mechanism Independent of Ca²⁺ Channel Blocking Free

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Cun-Jian Dong; Yuanxing Guo; Peter Agey; Larry Wheeler; William A. Hare

Tags: nimodipine, n-methyl-d-aspartate receptors, brimonidine, n-methylaspartate

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4174-4180. doi:https://doi.org/10.1167/iovs.09-4613

Retina

An Experimental Protocol of the Model to Quantify Traction Applied to the Retina by Vitreous Cutters Free

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Anderson Teixeira; Lawrence Chong; Naoki Matsuoka; Luis Arana; Jaw-Chyng Lue; Matthew McCormick; Ralph Kerns; Prashant Bhadri; Mark Humayun

Tags: retina, traction, vitreous body, eye

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4181-4186. doi:https://doi.org/10.1167/iovs.09-4852

Normal Physiological and Pathophysiological Effects of Trypan Blue on the Retinas of Albino Rabbits Free

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Gad Heilweil; Izabela Komarowska; Esther Zemel; Anat Loewenstein; Ido Perlman

Tags: albinism, electroretinography, oryctolagus cuniculus, retina, trypan blue

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4187-4194. doi:https://doi.org/10.1167/iovs.09-4675

Measurement of Ophthalmodynamometric Pressure with the Vented-Gas Forced-Infusion System during Pars Plana Vitrectomy Free

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Fumiki Okamoto; Yoshimi Sugiura; Yoshifumi Okamoto; Yumi Hasegawa; Takahiro Hiraoka; Tetsuro Oshika

Tags: eye, infusion procedures, intraocular pressure, poly(adp-ribose) polymerases, vitrectomy

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4195-4199. doi:https://doi.org/10.1167/iovs.10-5165

High-Resolution Fourier-Domain Optical Coherence Tomography of Choroidal Neovascular Membranes Associated with Age-Related Macular Degeneration Free

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Susanna S. Park; Steven N. Truong; Robert J. Zawadzki; Suhail Alam; Stacey S. Choi; David G. Telander; John S. Werner; Lawrence S. Morse

Tags: choroidal neovascularization, optical coherence tomography, eye, age-related macular degeneration

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4200-4206. doi:https://doi.org/10.1167/iovs.09-4256

Increased Fundus Autofluorescence Associated with Outer Segment Shortening in Macular Translocation Model of Neovascular Age-Related Macular Degeneration Free

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Fred K. Chen; Praveen J. Patel; Peter J. Coffey; Adnan Tufail; Lyndon Da Cruz

Tags: exudative age-related macular degeneration, fundus autofluorescence imaging, translocation (genetics)

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4207-4212. doi:https://doi.org/10.1167/iovs.09-4728

A Comparison of Visual Field Sensitivity to Photoreceptor Thickness in Retinitis Pigmentosa Free

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Nalini V. Rangaswamy; Hemaxi M. Patel; Kirsten G. Locke; Donald C. Hood; David G. Birch

Tags: photoreceptors, retinitis pigmentosa, visual fields

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4213-4219. doi:https://doi.org/10.1167/iovs.09-4945

Choroidal Blood Flow and Progression of Age-Related Macular Degeneration in the Fellow Eye in Patients with Unilateral Choroidal Neovascularization Free

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Agnes Boltz; Alexandra Luksch; Barbara Wimpissinger; Noemi Maar; Günther Weigert; Sophie Frantal; Werner Brannath; Gerhard Garhöfer; Erdem Ergun; Michael Stur; Leopold Schmetterer

Tags: age-related macular degeneration, choroidal neovascularization, eye, vascular flow

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4220-4225. doi:https://doi.org/10.1167/iovs.09-4968

Interferon γ–Inducible Protein-10 (IP-10) and Eotaxin as Biomarkers in Age-Related Macular Degeneration Free

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Fong Ming Mo; Alan D. Proia; Walter H. Johnson; Desiree Cyr; Kameran Lashkari

Tags: age-related macular degeneration, biological markers, choroidal neovascularization, cytokine, eye

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4226-4236. doi:https://doi.org/10.1167/iovs.09-3910

Apelin in Plasma and Vitreous and in Fibrovascular Retinal Membranes of Patients with Proliferative Diabetic Retinopathy Free

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Yong Tao; Qiang Lu; Yan-Rong Jiang; Jing Qian; Jia-Yan Wang; Lei Gao; Jost B. Jonas

Tags: plasma, proliferative diabetic retinopathy, tissue membrane, vitreous body, vascular endothelial growth factor a

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4237-4242. doi:https://doi.org/10.1167/iovs.09-4466

Intravitreous Delivery of the Corticosteroid Fluocinolone Acetonide Attenuates Retinal Degeneration in S334ter-4 Rats Free

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Inna V. Glybina; Alexander Kennedy; Paul Ashton; Gary W. Abrams; Raymond Iezzi

Tags: adrenal corticosteroids, electroretinography, eye, fluocinolone acetonide, glucocorticoids

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4243-4252. doi:https://doi.org/10.1167/iovs.09-4492

ABCA4 and ROM1: Implications for Modification of the PRPH2-Associated Macular Dystrophy Phenotype Free

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Charlotte M. Poloschek; Michael Bach; Wolf A. Lagrèze; Esther Glaus; Johannes R. Lemke; Wolfgang Berger; John Neidhardt

Tags: family, macular dystrophy, mutation, phenotype, retinitis pigmentosa

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4253-4265. doi:https://doi.org/10.1167/iovs.09-4655

Identification of Novel Mutations in the Ortholog of Drosophila Eyes Shut Gene (EYS) Causing Autosomal Recessive Retinitis Pigmentosa Free

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Mai M. Abd El-Aziz; Ciara A. O'Driscoll; Rebecca S. Kaye; Isabel Barragan; Mohamed F. El-Ashry; Salud Borrego; Guillermo Antiñolo; Chi Pui Pang; Andrew R. Webster; Shomi S. Bhattacharya

Tags: mutation, genes, retinitis pigmentosa, autosomal recessive inheritance

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4266-4272. doi:https://doi.org/10.1167/iovs.09-5109

VEGF-A₁₆₅b Is Cytoprotective and Antiangiogenic in the Retina Free

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Anette L. Magnussen; Emma S. Rennel; Jing Hua; Heather S. Bevan; Nicholas Beazley Long; Christina Lehrling; Melissa Gammons; Juergen Floege; Steven J. Harper; Hansjürgen T. Agostini; David O. Bates; Amanda J. Churchill

Tags: vascular endothelial growth factor a

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4273-4281. doi:https://doi.org/10.1167/iovs.09-4296

Recombinant Human VEGF₁₆₅b Inhibits Experimental Choroidal Neovascularization Free

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Jing Hua; Christine Spee; Satoru Kase; Emma S. Rennel; Anette L. Magnussen; Yan Qiu; Alex Varey; Sandeep Dhayade; Amanda J. Churchill; Steven J. Harper; David O. Bates; David R. Hinton

Tags: choroidal neovascularization, vascular endothelial growth factor a

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4282-4288. doi:https://doi.org/10.1167/iovs.09-4360

Characterization of Retinal and Blood Mitochondrial DNA from Age-Related Macular Degeneration Patients Free

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M. Cristina Kenney; Shari R. Atilano; David Boyer; Marilyn Chwa; Garrick Chak; Sahmon Chinichian; Pinar Coskun; Douglas C. Wallace; Anthony B. Nesburn; Nitin S. Udar

Tags: dna, mitochondrial, heteroplasmy

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4289-4297. doi:https://doi.org/10.1167/iovs.09-4778

The Cellular Expression of Antiangiogenic Factors in Fetal Primate Macula Free

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Peter Kozulin; Riccardo Natoli; Keely M. Bumsted O'Brien; Michele C. Madigan; Jan M. Provis

Tags: angiogenesis inhibitors, brain natriuretic peptide, fetus, macula densa, macula lutea

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4298-4306. doi:https://doi.org/10.1167/iovs.09-4905

Retinal Cell Biology

Gene Expression Profile of Hyperoxic and Hypoxic Retinas in a Mouse Model of Oxygen-Induced Retinopathy Free

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Keijiro Ishikawa; Shigeo Yoshida; Koji Kadota; Takanori Nakamura; Hiroaki Niiro; Satoshi Arakawa; Ayako Yoshida; Koichi Akashi; Tatsuro Ishibashi

Tags: genes, hypoxia, mice, retina, gene expression profiling

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4307-4319. doi:https://doi.org/10.1167/iovs.09-4605

Role of Matrix Metalloproteinase-9 in the Development of Diabetic Retinopathy and Its Regulation by H-Ras Free

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Renu A. Kowluru

Tags: diabetic retinopathy, gelatinase b, genes, ras, glucose, endothelial cells

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4320-4326. doi:https://doi.org/10.1167/iovs.09-4851

Exogenous SOD Mimetic Tempol Ameliorates the Early Retinal Changes Reestablishing the Redox Status in Diabetic Hypertensive Rats Free

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Mariana A. B. Rosales; Kamila C. Silva; José B. Lopes de Faria; Jacqueline M. Lopes de Faria

Tags: body tissue, diabetes mellitus, hypertension, oxidation-reduction, proteins

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4327-4336. doi:https://doi.org/10.1167/iovs.09-4690

Phototoxicity of Indocyanine Green under Continuous Fluorescent Lamp Illumination and Its Prevention by Blocking Red Light on Cultured Müller Cells Free

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Tomohito Sato; Masataka Ito; Masahiro Ishida; Yoko Karasawa

Tags: indocyanine green, light, lighting, lights, manufactured, phototoxicity

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4337-4345. doi:https://doi.org/10.1167/iovs.09-4707

Visual Psychophysics and Physiological Optics

Fixation Stability: A Comparison between the Nidek MP-1 and the Rodenstock Scanning Laser Ophthalmoscope in Persons with and without Diabetic Maculopathy Free

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Hannah M. P. Dunbar; Michael D. Crossland; Gary S. Rubin

Tags: diabetes mellitus, lasers, macular disorders, ophthalmoscopes

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 4346-4350. doi:https://doi.org/10.1167/iovs.09-4556

Clinical Trials

Tracking Progression with Spectral-Domain Optical Coherence Tomography in Geographic Atrophy Caused by Age-Related Macular Degeneration Free

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Monika Fleckenstein; Steffen Schmitz-Valckenberg; Christine Adrion; Irene Krämer; Nicole Eter; Hans Martin Helb; Christian K. Brinkmann; Peter Charbel Issa; Ulrich Mansmann; Frank G. Holz

Tags: age-related macular degeneration, atrophy, diagnostic imaging, eye, follow-up

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3846-3852. doi:https://doi.org/10.1167/iovs.09-4533

Letters to the Editor

Motion-Encoded MRIs Provide Evidence against Orbital Pulleys Free

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Robert S. Jampel

Tags: motion

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3841. doi:https://doi.org/10.1167/iovs.09-5016

Author Response: Motion-Encoded MRIs Provide Evidence against Orbital Pulleys Free

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Marco Piccirelli; Roger Luechinger; Veit Sturm; Peter Boesiger; Klara Landau; Oliver Bergamin

Tags: motion

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3841-3842. doi:https://doi.org/10.1167/iovs.09-5143

Donor Cell Survival in Corneal Grafts Free

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Gregor Wollensak

Tags: cell survival, donors, keratoplasty

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3842-3843. doi:https://doi.org/10.1167/iovs.09-5133

Author Response: Donor Cell Survival in Corneal Grafts Free

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Neil Lagali; Ulf Stenevi; Per Fagerholm; Margareta Claesson

Tags: cell survival, donors, keratoplasty

Investigative Ophthalmology & Visual Science August 2010, Vol.51, 3843-3845. doi:https://doi.org/10.1167/iovs.10-5328

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