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Anatomy and Pathology/Oncology

Examination of the Topographical Anatomy and Fetal Development of the Tendinous Annulus of Zinn for a Common Origin of the Extraocular Recti Open Access
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Tetsu Naito; Kwang Ho Cho; Masahito Yamamoto; Hidetomo Hirouchi; Gen Murakami; Shogo Hayashi; Shinichi Abe
Tags: annular ligament of radius, fetal development, tendon, fetus, adult
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4564-4573. doi:https://doi.org/10.1167/iovs.19-28094
Expression of Developmentally Important Axon Guidance Cues in the Adult Optic Chiasm Open Access
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Raquel Conceição; Rachel S. Evans; Craig S. Pearson; Barbara Hänzi; Andrew Osborne; Sarita S. Deshpande; Keith R. Martin; Amanda C. Barber
Tags: adult, axon guidance, cues, optic chiasms, mice
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4727-4739. doi:https://doi.org/10.1167/iovs.19-26732
Aqueous Humor Biomarkers Identify Three Prognostic Groups in Uveal Melanoma Open Access
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Annemijn P. A. Wierenga; Jinfeng Cao; Henk Mouthaan; Christiaan van Weeghel; Robert M. Verdijk; Sjoerd G. van Duinen; Wilma G. M. Kroes; Mehmet Dogrusöz; Marina Marinkovic; Sjoerd S. H. van der Burg; Gregorius P. M. Luyten; Martine J. Jager
Tags: aqueous humor, biological markers, biopsy, cytokine, intraocular melanoma
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4740-4747. doi:https://doi.org/10.1167/iovs.19-28309

Biochemistry and Molecular Biology

Chitinase-3-Like-1 Promotes M2 Macrophage Differentiation and Induces Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration Open Access
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Nana Xu; Qiyu Bo; Rong Shao; Jian Liang; Yuanqi Zhai; Shiqi Yang; Fenghua Wang; Xiaodong Sun
Tags: chitinase-3-like protein 1, choroidal neovascularization, macrophages, angiogenesis, exudative age-related macular degeneration
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4596-4605. doi:https://doi.org/10.1167/iovs.19-27493
Characterization of LSD1 Expression Within the Murine Eye Open Access
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Salma Ferdous; Hans E. Grossniklaus; Jeffrey H. Boatright; John M. Nickerson
Tags: eye, mice, proteins, retina
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4619-4631. doi:https://doi.org/10.1167/iovs.19-26728
P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts Open Access
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Minhong Xiang; Lijuan Mo; Yueping Zhan; Hang Wen; Huanming Zhou; Wanhong Miao
Tags: cellular senescence, conjunctivochalasis, fibroblasts, signal transduction, mitogen-activated protein kinases
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4643-4651. doi:https://doi.org/10.1167/iovs.19-27617
LncRNA PLCD3-OT1 Functions as a CeRNA to Prevent Age-Related Cataract by Sponging miR-224-5p and Regulating PLCD3 Expression Open Access
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Jing Xiang; Qin Chen; Lihua Kang; Guowei Zhang; Yong Wang; Bai Qin; Jian Wu; Tianqiu Zhou; Yongzhao Han; Huaijin Guan
Tags: apoptosis, cataract, senile, cell cycle, polymerase chain reaction, protein overexpression
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4670-4680. doi:https://doi.org/10.1167/iovs.19-27211
Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C Open Access
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Hun Lee; Hana Jeong; Chang Mok Lee; Jin-A Shin; Sung-Wuk Jang; Jae Hyuck Lee; So Young Park; Jae Yong Kim; Hungwon Tchah
Tags: fibroblasts, hpfs trial, mitomycin, pterygium, cell motility
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4784-4791. doi:https://doi.org/10.1167/iovs.19-27153

Clinical and Epidemiologic Research

Visual Field Loss in Patients With Diabetes in the Absence of Clinically-Detectable Vascular Retinopathy in a Nationally Representative Survey Open Access
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Yicheng K. Bao; Yan Yan; Mae Gordon; Janet B. McGill; Michael Kass; Rithwick Rajagopal
Tags: blindness, diabetes mellitus, diabetes mellitus, type 2, retinal diseases, surveys
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4711-4716. doi:https://doi.org/10.1167/iovs.19-28063
Macular Vessel Density Measured With Optical Coherence Tomography Angiography and Its Associations in a Large Population-Based Study Open Access
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Qi Sheng You; Jonathan C. H. Chan; Alex L. K. Ng; Bonnie K. N. Choy; Kendrick C. Shih; Janice J. C. Cheung; Jasper K. W. Wong; Jennifer W. H. Shum; Michael Y. Ni; Jimmy S. M. Lai; Gabriel M. Leung; Chui Ming Gemmy Cheung; Tien Yin Wong; Ian Y. H. Wong
Tags: angiogram, optical coherence tomography, retinal vessels
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4830-4837. doi:https://doi.org/10.1167/iovs.19-28137
Geometry of the Retinal Nerve Fibers From Emmetropia Through to High Myopia at Both the Temporal Raphe and Optic Nerve Open Access
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Phillip Bedggood; Soumya Mukherjee; Bao N. Nguyen; Andrew Turpin; Allison M. McKendrick
Tags: emmetropia, myopia, nerve fibers, retinal nerve fiber layer, optic nerve
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4896-4903. doi:https://doi.org/10.1167/iovs.19-27539
Long Noncoding RNA PVT1 Silencing Prevents the Development of Uveal Melanoma by Impairing MicroRNA-17-3p–Dependent MDM2 Upregulation Open Access
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Shuai Wu; Han Chen; Ning Han; Chunxia Zhang; Hongtao Yan
Tags: intraocular melanoma, micrornas, rna, untranslated, up-regulation (physiology)
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4904-4914. doi:https://doi.org/10.1167/iovs.19-27704

Cornea

Graft Versus Host Disease-Associated Dry Eye: Role of Ocular Surface Mucins and the Effect of Rebamipide, a Mucin Secretagogue Open Access
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Kiumars Shamloo; Ashley Barbarino; Saleh Alfuraih; Ajay Sharma
Tags: cornea, dry eye syndromes, graft-versus-host disease, mucins, rebamipide
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4511-4519. doi:https://doi.org/10.1167/iovs.19-27843
Comparison of MicroRNA Expression in Tears of Normal Subjects and Sjögren Syndrome Patients Open Access
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Yu Jeong Kim; Yeji Yeon; Won June Lee; Yong Un Shin; Heeyoon Cho; Yoon-Kyoung Sung; Du Roo Kim; Han Woong Lim; Min Ho Kang
Tags: micrornas, sjogren's syndrome
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4889-4895. doi:https://doi.org/10.1167/iovs.19-27062

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Abnormal Monocular and Dichoptic Temporal Synchrony in Adults with Amblyopia Open Access
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Chunwen Tao; Yidong Wu; Ling Gong; Shijia Chen; Yu Mao; Yiya Chen; Jiawei Zhou; Pi-Chun Huang
Tags: adult, amblyopia, eye
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4858-4864. doi:https://doi.org/10.1167/iovs.19-27893

Genetics

Expanding the Genetic Landscape of Usher-Like Phenotypes Open Access
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Carla Fuster-García; Gema García-García; Teresa Jaijo; Fiona Blanco-Kelly; Lifeng Tian; Hakon Hakonarson; Carmen Ayuso; Elena Aller; José M. Millán
Tags: family, genetics, phenotype, genes, mutation
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4701-4710. doi:https://doi.org/10.1167/iovs.19-27470
Replication of Genome-Wide Association Analysis Identifies New Susceptibility Loci at Long Noncoding RNA Regions for Vogt-Koyanagi-Harada Disease Open Access
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Jian Qi; Liping Du; Jing Deng; Yang Qin; Guannan Su; Shengping Hou; Meng Lv; Qi Zhang; Aize Kijlstra; Peizeng Yang
Tags: cytokine, disease susceptibility, genome-wide association study, genotype, rna, messenger
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4820-4829. doi:https://doi.org/10.1167/iovs.19-27708

Glaucoma

Association of Systemic Medication Exposure With Glaucoma Progression and Glaucoma Suspect Conversion in the Groningen Longitudinal Glaucoma Study Open Access
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Konstantinos Pappelis; Allison R. Loiselle; Stijn Visser; Nomdo M. Jansonius
Tags: glaucoma, pharmaceutical preparations, open-angle glaucoma
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4548-4555. doi:https://doi.org/10.1167/iovs.19-27984
Vision Parameters Most Important to Functionality in Glaucoma Open Access
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Ahmed F. Shakarchi; Aleksandra Mihailovic; Sheila K. West; David S. Friedman; Pradeep Y. Ramulu
Tags: glaucoma, vision
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4556-4563. doi:https://doi.org/10.1167/iovs.19-28023
Phenotypic and Functional Alterations in Tunneling Nanotubes Formed by Glaucomatous Trabecular Meshwork Cells Open Access
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Ying Ying Sun; John M. Bradley; Kate E. Keller
Tags: actins, glaucoma, immunohistochemistry, phenotype, trabecular meshwork
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4583-4595. doi:https://doi.org/10.1167/iovs.19-28084
Posttreatment Intervention With Lycium Barbarum Polysaccharides is Neuroprotective in a Rat Model of Chronic Ocular Hypertension Open Access
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Yamunadevi Lakshmanan; Francisca Siu Yin Wong; Bing Zuo; Kwok-Fai So; Bang Viet Bui; Henry Ho-Lung Chan
Tags: electroretinography, eye, glaucoma, intraocular pressure, ocular hypertension
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4606-4618. doi:https://doi.org/10.1167/iovs.19-27886
Lowered Decorin With Aberrant Extracellular Matrix Remodeling in Aqueous Humor and Tenon's Tissue From Primary Glaucoma Patients Open Access
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Sampath NikhalaShree; Gayathree Karthikkeyan; Ronnie George; Balekudaru Shantha; Lingam Vijaya; Vineet Ratra; Konerirajapuram Natarajan Sulochana; Karunakaran Coral
Tags: aqueous humor, body tissue, connective tissue growth factor, extracellular matrix, glaucoma
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4661-4669. doi:https://doi.org/10.1167/iovs.19-27091
The Relationship Between Ambient Atmospheric Fine Particulate Matter (PM2.5) and Glaucoma in a Large Community Cohort Open Access
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Sharon Y. L. Chua; Anthony P. Khawaja; James Morgan; Nicholas Strouthidis; Charles Reisman; Andrew D. Dick; Peng T. Khaw; Praveen J. Patel; Paul J. Foster; for the UK Biobank Eye and Vision Consortium
Tags: cohort studies, glaucoma, particulate matter, community, intraocular pressure
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4915-4923. doi:https://doi.org/10.1167/iovs.19-28346

Immunology and Microbiology

Neutrophil Activities in Human Ocular Toxoplasmosis: An In Vitro Study With Human Cells Open Access
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Liam M. Ashander; Shervi Lie; Yuefang Ma; Elise Rochet; Jennifer M. Washington; João M. Furtado; Binoy Appukuttan; Justine R. Smith
Tags: neutrophils, ocular toxoplasmosis, infections, retinal pigment cell
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4652-4660. doi:https://doi.org/10.1167/iovs.19-28306
Composition and Diversity of Bacterial Community on the Ocular Surface of Patients With Meibomian Gland Dysfunction Open Access
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Xiaojin Dong; Yuqian Wang; Weina Wang; Ping Lin; Yusen Huang
Tags: meibomian gland dysfunction, microbiome, community, conjunctival sac
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4774-4783. doi:https://doi.org/10.1167/iovs.19-27719

Lens

A Novel Human Congenital Cataract Mutation in EPHA2 Kinase Domain (p.G668D) Alters Receptor Stability and Function Open Access
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Yi Zhai; Sha Zhu; Jinyu Li; Ke Yao
Tags: congenital cataract, mutation, phosphotransferases, proteins, receptor, epha2
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4717-4726. doi:https://doi.org/10.1167/iovs.19-27370
Pharmacological Targeting of BET Bromodomains Inhibits Lens Fibrosis via Downregulation of MYC Expression Open Access
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Xiaoran Wang; Bowen Wang; Na Zhao; Chenjie Wang; Mi Huang; Baoxin Chen; Jieping Chen; Yan Sun; Lang Xiong; Shan Huang; Yizhi Liu
Tags: down-regulation, epithelial to mesenchymal transition, fibrosis, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4748-4758. doi:https://doi.org/10.1167/iovs.19-27596

Physiology and Pharmacology

Propranolol Attenuates Proangiogenic Activity of Mononuclear Phagocytes: Implication in Choroidal Neovascularization Open Access
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Samy Omri; Houda Tahiri; Wyston Chadwick Pierre; Michel Desjarlais; Isabelle Lahaie; Sarah-Eve Loiselle; Flavio Rezende; Gregory Lodygensky; Terence E. Hebert; Huy Ong; Sylvain Chemtob
Tags: choroidal neovascularization, propranolol, reticuloendothelial system, macrophages, angiogenesis
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4632-4642. doi:https://doi.org/10.1167/iovs.18-25502

Retina

Relationship Between Cone Loss and Microvasculature Change in Retinitis Pigmentosa Open Access
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Rui Lin; Meixiao Shen; Deng Pan; Su-Zhong Xu; Ren-Juan Shen; Yilei Shao; Ce Shi; Fan Lu; Zi-Bing Jin
Tags: diagnostic imaging, retinal cone, retinitis pigmentosa, eye
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4520-4531. doi:https://doi.org/10.1167/iovs.19-27114
Topographic Distribution of Contractile Protein in the Human Macular Microvasculature Open Access
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Paula K. Yu; Dong An; Chandrakumar Balaratnasingam; Stephen J. Cringle; Dao-Yi Yu
Tags: actins, arteriole, blood capillaries, contractile proteins, eye
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4574-4582. doi:https://doi.org/10.1167/iovs.19-26986
Clinical Stages of Occult Macular Dystrophy Based on Optical Coherence Tomographic Findings Open Access
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Natsuko Nakamura; Kazushige Tsunoda; Yoshinobu Mizuno; Tomoaki Usui; Tetsuhisa Hatase; Shinji Ueno; Kazuki Kuniyoshi; Takaaki Hayashi; Satoshi Katagiri; Mineo Kondo; Shuhei Kameya; Kazutoshi Yoshitake; Kaoru Fujinami; Takeshi Iwata; Yozo Miyake
Tags: macular dystrophy, optical coherence tomography, visual acuity, visual symptoms, survival curve
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4691-4700. doi:https://doi.org/10.1167/iovs.19-27486
IPL Sublamination in Chicken Retinal Spheroids Is Initiated via Müller Cells and Cholinergic Differentiation, and Is Disrupted by NMDA Signaling Open Access
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Gesine Bachmann; Florian Frohns; Gopenath Thangaraj; Alexander Bausch; Paul G. Layer
Tags: chickens, cholinergic agents, glutamate, glutamates, n-methylaspartate
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4759-4773. doi:https://doi.org/10.1167/iovs.18-24952
Macular Ganglion Cell-Inner Plexiform Layer, Ganglion Cell Complex, and Outer Retinal Layer Thicknesses in a Large Cohort of Chinese Children Open Access
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Lu Cheng; Mingjin Wang; Junjie Deng; Minzhi Lv; Wenhan Jiang; Shuyu Xiong; Sifei Sun; Jianfeng Zhu; Haidong Zou; Xiangui He; Xun Xu
Tags: child, chinese (other dialects), chinese people, cohort studies, ganglia
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4792-4802. doi:https://doi.org/10.1167/iovs.18-26300
Homozygous Variant in ARL3 Causes Autosomal Recessive Cone Rod Dystrophy Open Access
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Shakeel A. Sheikh; Robert A. Sisk; Cara R. Schiavon; Yar M. Waryah; Muhammad A. Usmani; David H. Steel; John A. Sayer; Ashok K. Narsani; Robert B. Hufnagel; Saima Riazuddin; Richard A. Kahn; Ali M. Waryah; Zubair M. Ahmed
Tags: autosomal recessive inheritance, family, homozygote, mutation, phenotype
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4811-4819. doi:https://doi.org/10.1167/iovs.19-27263
Subretinal Drusenoid Deposits in the Elderly in a Population-Based Study (the Montrachet Study) Open Access
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Pierre-Henry Gabrielle; Alassane Seydou; Louis Arnould; Niyazi Acar; Hervé Devilliers; Florian Baudin; Ines Ben Ghezala; Christine Binquet; Alain Marie Bron; Catherine Creuzot-Garcher
Tags: digestive tract decontamination, eye, older adult, spectral domain-optical coherence tomography, prevalence
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4838-4848. doi:https://doi.org/10.1167/iovs.19-27283
Retinal and Choroidal Perfusion Status in the Area of Laser Scars Assessed With Swept-Source Optical Coherence Tomography Angiography Open Access
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Sonja G. Karst; Hannes Beiglboeck; Raffael Scharinger; Elias L. Meyer; Christoph Mitsch; Christoph Scholda; Ursula M. Schmidt-Erfurth
Tags: angiogram, chief complaint, cicatrix, lasers, light coagulation
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4865-4871. doi:https://doi.org/10.1167/iovs.19-27977
Characteristics of Posterior Precortical Vitreous Pockets and Cloquet's Canal in Patients with Myopia by Optical Coherence Tomography Open Access
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Xiangjun She; Xin Ye; Ruru Chen; Deming Pan; Lijun Shen
Tags: hypertrophy, myopia, vitreous body, optical coherence tomography
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4882-4888. doi:https://doi.org/10.1167/iovs.19-27426
Emixustat Reduces Metabolic Demand of Dark Activity in the Retina Open Access
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Ryo Kubota; David J. Calkins; Susan H. Henry; Robert A. Linsenmeier
Tags: dark adaptation, oxygen, rats, retina, cations
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4924-4930. doi:https://doi.org/10.1167/iovs.19-28194
Cone Structure Persists Beyond Margins of Short-Wavelength Autofluorescence in Choroideremia Open Access
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Katharina G. Foote; Nicholas Rinella; Janette Tang; Nicolas Bensaid; Hao Zhou; Qinqin Zhang; Ruikang K. Wang; Travis C. Porco; Austin Roorda; Jacque L. Duncan
Tags: autofluorescence, chief complaint, choroideremia, diagnostic imaging, photoreceptors
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4931-4942. doi:https://doi.org/10.1167/iovs.19-27979
Low Birth Weight Is Linked to Age-Related Macular Degeneration: Results From the Population-Based Gutenberg Health Study (GHS) Open Access
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Achim Fieß; Hisham Elbaz; Christina A. Korb; Stefan Nickels; Andreas Schulz; Thomas Münzel; Philipp S. Wild; Manfred E. Beutel; Irene Schmidtmann; Karl J. Lackner; Tunde Peto; Norbert Pfeiffer; Alexander K. Schuster
Tags: birth weight, low birth weight infant, age-related macular degeneration, prevalence, health
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4943-4950. doi:https://doi.org/10.1167/iovs.19-27964

Retinal Cell Biology

Growth Hormone Neuroprotection Against Kainate Excitotoxicity in the Retina is Mediated by Notch/PTEN/Akt Signaling Open Access
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Thomas Fleming; Jerusa E. Balderas-Márquez; David Epardo; José Ávila-Mendoza; Martha Carranza; Maricela Luna; Steve Harvey; Carlos Arámburo; Carlos G. Martínez-Moreno
Tags: excitotoxicity, neuroprotection, notch1 gene, proto-oncogene proteins c-akt, pten gene
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4532-4547. doi:https://doi.org/10.1167/iovs.19-27473
Role of Translational Attenuation in Inherited Retinal Degeneration Open Access
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Christopher R. Starr; Cyril N. A. Nyankerh; Xiaoping Qi; Yang Hu; Oleg S. Gorbatyuk; Nahum Sonenberg; Michael E. Boulton; Marina S. Gorbatyuk
Tags: attenuation, electroretinography, mice, protein biosynthesis, retina
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4849-4857. doi:https://doi.org/10.1167/iovs.19-27512

Visual Neuroscience

Correspondence Between Behavioral, Physiological, and Anatomical Measurements of Visual Function in Inhibitory Neuron–Ablated Zebrafish Open Access
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Jiaheng Xie; Patrick T. Goodbourn; Bang V. Bui; Tamar E. Sztal; Patricia R. Jusuf
Tags: ablation, electroretinography, larva, neurons, phenotype
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4681-4690. doi:https://doi.org/10.1167/iovs.19-27544
Retinal Function in X-Linked Juvenile Retinoschisis Open Access
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Lucia Ambrosio; Ronald M. Hansen; Rotem Kimia; Anne B. Fulton
Tags: electroretinography, retinal cone, rod photoreceptors, x-linked retinoschisis, photoreceptors
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4872-4881. doi:https://doi.org/10.1167/iovs.19-27897

Lecture

Introducing Sheila K. West, the Recipient of the 2019 Weisenfeld Award Open Access
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Alfred Sommer
Tags: awards and prizes
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4803-4804. doi:https://doi.org/10.1167/iovs.19-28630
Toward the Elimination of Disease: the 2019 Weisenfeld Award Lecture Open Access
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Sheila K. West
Tags: awards and prizes, trachoma, pathogenesis, infections, child
Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4805-4810. doi:https://doi.org/10.1167/iovs.19-28629
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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