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Anatomy and Pathology/Oncology

Observation of Posterior Precortical Vitreous Pocket Using Swept-Source Optical Coherence Tomography Free
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Hirotaka Itakura; Shoji Kishi; Danjie Li; Hideo Akiyama
Tags: eye, optical coherence tomography, vitreous body, refractive errors, fovea centralis
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3102-3107. doi:https://doi.org/10.1167/iovs.13-11769
Disruption of the Centrifugal Visual System Inhibits Early Eye Growth in Chicks Free
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Christopher Mark Dillingham; Jeremy Andrew Guggenheim; Jonathan Thor Erichsen
Tags: eye, visual system, retina, hyperopia, refractive errors
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3632-3643. doi:https://doi.org/10.1167/iovs.12-11548

Biochemistry and Molecular Biology

Effects of Thailanstatins on Glucocorticoid Response in Trabecular Meshwork and Steroid-Induced Glaucoma Free
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Ankur Jain; Xiangyang Liu; Robert J. Wordinger; Thomas Yorio; Yi-Qiang Cheng; Abbot F. Clark
Tags: glucocorticoids, luciferases, proteins, steroid-induced glaucoma, trabecular meshwork
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3137-3142. doi:https://doi.org/10.1167/iovs.12-11480
A Functional Polymorphism at the FGF10 Gene Is Associated With Extreme Myopia Free
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Edward Hsi; Ku-Chung Chen; Wan-Shu Chang; Ming-Lung Yu; Chung-Ling Liang; Suh-Hang Hank Juo
Tags: fgf10 protein, human, genes, myopia, polymorphism, luciferases
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3265-3271. doi:https://doi.org/10.1167/iovs.13-11814
The Artemisinin Derivative Artesunate Inhibits Corneal Neovascularization by Inducing ROS-Dependent Apoptosis in Vascular Endothelial Cells Free
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Rui Cheng; Cen Li; Chaoyang Li; Ling Wei; Lei Li; Yang Zhang; Yachao Yao; Xiaoqiong Gu; Weibin Cai; Zhonghan Yang; Jianxing Ma; Xia Yang; Guoquan Gao
Tags: apoptosis, artemisinine, artesunate, corneal neovascularization, endothelial cells
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3400-3409. doi:https://doi.org/10.1167/iovs.12-11068
Intraocular Biomarker Identification in Uveitis Associated With Juvenile Idiopathic Arthritis Free
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Viera Kalinina Ayuso; Joke H. de Boer; Helen L. Byers; Gary R. Coulton; Jojanneke Dekkers; Lenneke de Visser; Anton M. van Loon; Peter A. W. J. F. Schellekens; Aniki Rothova; Jolanda D. F. de Groot-Mijnes
Tags: arthritis, juvenile rheumatoid, biological markers, hypertension, proteins, uveitis
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3709-3720. doi:https://doi.org/10.1167/iovs.12-10865

Clinical and Epidemiologic Research

Cost-Effectiveness of Treating Normal Tension Glaucoma Free
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Emmy Y. Li; Clement C. Tham; Stanley C. Chi; Dennis S. Lam
Tags: cost effectiveness, health, low tension glaucoma, pharmaceutical preparations, sensitivity analysis
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3394-3399. doi:https://doi.org/10.1167/iovs.12-11549
Choroidal Thickness in Childhood Free
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Scott A. Read; Michael J. Collins; Stephen J. Vincent; David Alonso-Caneiro
Tags: child, choroid
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3586-3593. doi:https://doi.org/10.1167/iovs.13-11732
Racial Differences in Retinal Vessel Geometric Characteristics: A Multiethnic Study in Healthy Asians Free
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Xiang Li; Wan Ling Wong; Carol Yim-lui Cheung; Ching-Yu Cheng; Mohammad Kamran Ikram; Jialiang Li; Kee Seng Chia; Tien Yin Wong
Tags: asian, chinese people, fractals, racial differences, retinal vascular caliber
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3650-3656. doi:https://doi.org/10.1167/iovs.12-11126
Binocular Vision and Eye Movement Disorders in Older Adults Free
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Susan J. Leat; Lisa Li-Li Chan; Priya-Devi Maharaj; Patricia K. Hrynchak; Andrea Mittelstaedt; Carolyn M. Machan; Elizabeth L. Irving
Tags: ocular motility disorders, older adult, prevalence, strabismus, vision, binocular
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3798-3805. doi:https://doi.org/10.1167/iovs.12-11582

Cornea

Sunitinib Inhibits Inflammatory Corneal Lymphangiogenesis Free
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Benoît Detry; Silvia Blacher; Charlotte Erpicum; Jenny Paupert; Ludovic Maertens; Catherine Maillard; Carine Munaut; Nor Eddine Sounni; Vincent Lambert; Jean-Michel Foidart; Jean-Marie Rakic; Didier Cataldo; Agnès Noël
Tags: cornea, corneal neovascularization, lymphangiogenesis, sunitinib
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3082-3093. doi:https://doi.org/10.1167/iovs.12-10856
Transcription Factors Runx1 to 3 Are Expressed in the Lacrimal Gland Epithelium and Are Involved in Regulation of Gland Morphogenesis and Regeneration Free
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Dmitry Voronov; Anastasia Gromova; Daren Liu; Driss Zoukhri; Alexander Medvinsky; Robyn Meech; Helen P. Makarenkova
Tags: epithelium, lacrimal gland, morphogenesis, transcription factor, regulation
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3115-3125. doi:https://doi.org/10.1167/iovs.13-11791
Abnormal Corneal Endothelial Maturation in Collagen XII and XIV Null Mice Free
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Chinda Hemmavanh; Manuel Koch; David E. Birk; Edgar M. Espana
Tags: collagen, cornea, endothelium, mice, mice, knockout
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3297-3308. doi:https://doi.org/10.1167/iovs.12-11456
Factors Predicting the Ocular Surface Response to Desiccating Environmental Stress Free
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Anastasia Alex; Austin Edwards; J. Daniel Hays; Michelle Kerkstra; Amanda Shih; Cintia S. de Paiva; Stephen C. Pflugfelder
Tags: cornea, dry eye syndromes, signs and symptoms, stress, conjunctiva
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3325-3332. doi:https://doi.org/10.1167/iovs.12-11322
Wavelength Optimization in Femtosecond Laser Corneal Surgery Free
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Caroline Crotti; Florent Deloison; Fatima Alahyane; Florent Aptel; Laura Kowalczuk; Jean-Marc Legeais; Donald A. Peyrot; Michèle Savoldelli; Karsten Plamann
Tags: cornea, edema, femtosecond pulsed lasers, lasers, operative procedure on cornea
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3340-3349. doi:https://doi.org/10.1167/iovs.12-10694
Collagen Cross-Linking Using Rose Bengal and Green Light to Increase Corneal Stiffness Free
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Daniel Cherfan; E. Eri Verter; Samir Melki; Thomas E. Gisel; Francis J. Doyle, Jr; Giuliano Scarcelli; Seok Hyun Yun; Robert W. Redmond; Irene E. Kochevar
Tags: cornea, green light, rose bengal, corneal collagen cross-linking
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3426-3433. doi:https://doi.org/10.1167/iovs.12-11509
In Vivo Corneal Oxygen Uptake During Soft-Contact-Lens Wear Free
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Sho C. Takatori; Percy Lazon de la Jara; Brien Holden; Klaus Ehrmann; Arthur Ho; Clayton J. Radke
Tags: cornea, oxygen, contact lenses, hydrophilic, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3472-3479. doi:https://doi.org/10.1167/iovs.12-11169
Dry Eye Syndrome, Posttraumatic Stress Disorder, and Depression in an Older Male Veteran Population Free
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Cristina A. Fernandez; Anat Galor; Kristopher L. Arheart; Dominique L. Musselman; Vincent D. Venincasa; Hermes J. Florez; David J. Lee
Tags: depressive disorders, dry eye syndromes, post-traumatic stress disorder, signs and symptoms, veterans
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3666-3672. doi:https://doi.org/10.1167/iovs.13-11635
Factors Affecting Corneoscleral Topography Free
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Lee A. Hall; Chris Hunt; Graeme Young; James Wolffsohn
Tags: cornea, eye, limbus corneae, sclera, refractive errors
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3691-3701. doi:https://doi.org/10.1167/iovs.13-11657
Comparison of Low-Abundance Biomarker Levels in Capillary-Collected Nonstimulated Tears and Washout Tears of Aqueous-Deficient and Normal Patients Free
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Nicole Guyette; Larezia Williams; My-Tho Tran; Tammy Than; John Bradley; Lucy Kehinde; Clara Edwards; Mark Beasley; Roderick Fullard
Tags: biological markers, blood capillaries, cytokine, dry eye syndromes
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3729-3737. doi:https://doi.org/10.1167/iovs.12-11431
Increased Fragility, Impaired Differentiation, and Acceleration of Migration of Corneal Epithelium of Epiplakin-Null Mice Free
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Masahide Kokado; Yuka Okada; Mizuki Goto; Kazushi Ishikawa; Takeshi Miyamoto; Osamu Yamanaka; Sakuhei Fujiwara; Shizuya Saika
Tags: corneal epithelium, diffuse palmoplantar keratoderma, mice, epithelium, cornea
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3780-3789. doi:https://doi.org/10.1167/iovs.12-11077
Overexpression of SIRT1 Promotes High Glucose–Attenuated Corneal Epithelial Wound Healing via p53 Regulation of the IGFBP3/IGF-1R/AKT Pathway Free
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Ye Wang; Xiaowen Zhao; Daling Shi; Peng Chen; Yang Yu; Lingling Yang; Lixin Xie
Tags: akt signaling pathway, attenuation, cornea, epithelium, glucose
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3806-3814. doi:https://doi.org/10.1167/iovs.13-12091

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Vertical Vergence Adaptation Produces an Objective Vertical Deviation That Changes With Head Tilt Free
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Kristina Irsch; David L. Guyton; Nicholas A. Ramey; Rohit S. Adyanthaya; Howard S. Ying
Tags: eye, eye movement, health disparity, paresis, standard operating procedure
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3108-3114. doi:https://doi.org/10.1167/iovs.12-11368
Visual Deprivation and Foveation Characteristics Both Underlie Visual Acuity Deficits in Idiopathic Infantile Nystagmus Free
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Joost Felius; Zainab A. Muhanna
Tags: pathologic nystagmus, visual acuity, child
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3520-3525. doi:https://doi.org/10.1167/iovs.13-11992

Genetics

Screening of RB1 Alterations in Brazilian Patients With Retinoblastoma and Relatives With Retinoma: Phenotypic and Genotypic Associations Free
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Raquel H. Barbosa; Fernanda C. C. Aguiar; Morgana F. L. Silva; Regis A. Costa; Fernando R. Vargas; Evandro Lucena; Mírian Carvalho de Souza; Liz Maria de Almeida; Camila Bittar; Patrícia Ashton Prolla; Cibele R. Bonvicino; Héctor N. Seuánez
Tags: genotype, introns, phenotype, retinoblastoma, screening
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3184-3194. doi:https://doi.org/10.1167/iovs.13-11686
Mutational Spectrum of the ZEB1 Gene in Corneal Dystrophies Supports a Genotype–Phenotype Correlation Free
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Judith Lechner; Durga P. Dash; Dorota Muszynska; Mohsen Hosseini; Fani Segev; Sonia George; David G. Frazer; Jonathan E. Moore; Stephen B. Kaye; Terri Young; David A. Simpson; Amanda J. Churchill; Elise Héon; Colin E. Willoughby
Tags: cornea, genes, genotype-phenotype associations, hereditary corneal dystrophy, keratoconus
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3215-3223. doi:https://doi.org/10.1167/iovs.13-11781
JAK1, but Not JAK2 and STAT3, Confers Susceptibility to Vogt–Koyanagi–Harada (VKH) Syndrome in a Han Chinese Population Free
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Ke Hu; Shengping Hou; Fuzhen Li; Qin Xiang; Aize Kijlstra; Peizeng Yang
Tags: chinese (other dialects), chinese people, disease susceptibility, stat3 protein, syndrome
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3360-3365. doi:https://doi.org/10.1167/iovs.13-11615
Copy Number Variation at Chromosome 5q21.2 Is Associated With Intraocular Pressure Free
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Abhishek Nag; Cristina Venturini; Pirro G. Hysi; Matthew Arno; Estibaliz Aldecoa-Otalora Astarloa; Stuart MacGregor; Alex W. Hewitt; Terri L. Young; Paul Mitchell; Ananth C. Viswanathan; David A. Mackey; Christopher J. Hammond
Tags: chromosomes, copy number polymorphism, intraocular pressure, genes, glaucoma
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3607-3612. doi:https://doi.org/10.1167/iovs.13-11952
Heritability of Myopia and Ocular Biometrics in Koreans: The Healthy Twin Study Free
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Myung Hun Kim; Di Zhao; Woori Kim; Dong-Hui Lim; Yun-Mi Song; Eliseo Guallar; Juhee Cho; Joohon Sung; Eui-Sang Chung; Tae-Young Chung
Tags: biometry, myopia, twin studies, twins, astigmatism
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3644-3649. doi:https://doi.org/10.1167/iovs.12-11254

Glaucoma

Longitudinal Changes in Anterior Segment Parameters After Laser Peripheral Iridotomy Assessed by Anterior Segment Optical Coherence Tomography Free
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Kyoung Sub Lee; Kyung Rim Sung; Kilhwan Shon; Jae Hong Sun; Jong Rak Lee
Tags: laser iridotomy, optical coherence tomography, anterior chamber of eye
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3166-3170. doi:https://doi.org/10.1167/iovs.13-11630
Acetylcholinesterase Inhibition Promotes Retinal Vasoprotection and Increases Ocular Blood Flow in Experimental Glaucoma Free
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Mohammadali Almasieh; Jessica N. MacIntyre; Mylène Pouliot; Christian Casanova; Elvire Vaucher; Melanie E. M. Kelly; Adriana Di Polo
Tags: galantamine, glaucoma, microvascular network, vascular flow, acetylcholinesterase
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3171-3183. doi:https://doi.org/10.1167/iovs.12-11481
The Relationship Between Cup-to-Disc Ratio and Estimated Number of Retinal Ganglion Cells Free
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Andrew J. Tatham; Robert N. Weinreb; Linda M. Zangwill; Jeffrey M. Liebmann; Christopher A. Girkin; Felipe A. Medeiros
Tags: eye, glaucoma, optic disk, retinal ganglion cells, perimetry
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3205-3214. doi:https://doi.org/10.1167/iovs.12-11467
Detecting Glaucoma With Visual Fields Derived From Frequency-Domain Optical Coherence Tomography Free
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Xian Zhang; Ali S. Raza; Donald C. Hood
Tags: eye, glaucoma, optical coherence tomography, visual fields, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3289-3296. doi:https://doi.org/10.1167/iovs.13-11639
Overexpression of SPARC in Human Trabecular Meshwork Increases Intraocular Pressure and Alters Extracellular Matrix Free
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Dong-Jin Oh; Min Hyung Kang; Yen Hoong Ooi; Kyu Ryong Choi; E. Helene Sage; Douglas J. Rhee
Tags: protein overexpression, sparc study, intraocular pressure, proteins
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3309-3319. doi:https://doi.org/10.1167/iovs.12-11362
Reduction in Blood Glutathione Levels Occurs Similarly in Patients With Primary-Open Angle or Normal Tension Glaucoma Free
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Doina Gherghel; Stephanie Mroczkowska; Lu Qin
Tags: glaucoma, glutathione, low tension glaucoma, open-angle glaucoma, glutathione disulfide
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3333-3339. doi:https://doi.org/10.1167/iovs.12-11256
Sodium Hyaluronate Decreases Ocular Surface Toxicity Induced by Benzalkonium Chloride–Preserved Latanoprost: An In Vivo Study Free
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Fenfen Yu; Xing Liu; Yimin Zhong; Xinxing Guo; Mei Li; Zhen Mao; Hui Xiao; Shasha Yang
Tags: benzalkonium chloride, conjunctiva, latanoprost, sodium, toxic effect
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3385-3393. doi:https://doi.org/10.1167/iovs.12-11181
Comparison of Different Spectral Domain OCT Scanning Protocols for Diagnosing Preperimetric Glaucoma Free
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Renato Lisboa; Augusto Paranhos, Jr; Robert N. Weinreb; Linda M. Zangwill; Mauro T. Leite; Felipe A. Medeiros
Tags: glaucoma, optic disk, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3417-3425. doi:https://doi.org/10.1167/iovs.13-11676
Structural and Functional Effects of Hemiretinal Endodiathermy Axotomy in Cynomolgus Macaques Free
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Ryan J. Dashek; Charlene B. Y. Kim; Carol A. Rasmussen; Elizabeth A. Hennes-Beean; James N. VerHoeve; T. Michael Nork
Tags: axotomy, eye, macaca fascicularis, retina, optic nerve
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3479-3492. doi:https://doi.org/10.1167/iovs.12-11265
Does Acute Primary Angle-Closure Cause an Increased Choroidal Thickness? Free
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Wei Wang; Minwen Zhou; Wenbin Huang; Shida Chen; Xiaoyan Ding; Xiulan Zhang
Tags: atrial premature complexes, eye, intraocular pressure, primary angle closure suspect
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3538-3545. doi:https://doi.org/10.1167/iovs.13-11728
A Magnetic Bead-Based Method for Mouse Trabecular Meshwork Cell Isolation Free
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Weiming Mao; Yang Liu; Robert J. Wordinger; Abbot F. Clark
Tags: cell separation, medication therapy management, mice, trabecular meshwork, eye
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3600-3606. doi:https://doi.org/10.1167/iovs.13-12033
Longitudinal Analysis of Progression in Glaucoma Using Spectral-Domain Optical Coherence Tomography Free
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Julia M. Wessel; Folkert K. Horn; Ralf P. Tornow; Matthias Schmid; Christian Y. Mardin; Friedrich E. Kruse; Anselm G. Juenemann; Robert Laemmer
Tags: glaucoma, retinal nerve fiber layer, eye, optical coherence tomography, optic disk
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3613-3620. doi:https://doi.org/10.1167/iovs.12-9786
Association Between Baseline Angle Width and Induced Angle Opening Following Prophylactic Laser Peripheral Iridotomy Free
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Roland Y. Lee; Toshimitsu Kasuga; Qi N. Cui; Guofu Huang; Mingguang He; Shan C. Lin
Tags: anterior chamber of eye, eye, laser iridotomy, immune reconstitution inflammatory syndrome, preoperative care
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3763-3770. doi:https://doi.org/10.1167/iovs.13-11597

Immunology and Microbiology

Mature Dendritic Cell Suppression by IL-1 Receptor Antagonist on Retinal Pigment Epithelium Cells Free
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Sunao Sugita; Yuko Kawazoe; Ayano Imai; Yoshihiko Usui; Yoichiro Iwakura; Kikuo Isoda; Masataka Ito; Manabu Mochizuki
Tags: interleukin-1 receptor antagonists, retinal pigment cell, dendritic cells, tumor necrosis factors, mice
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3240-3249. doi:https://doi.org/10.1167/iovs.12-11483
lukSF-PV in Staphylococcus aureus Keratitis Isolates and Association With Clinical Outcome Free
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Henri Sueke; Jayendra Shankar; Timothy Neal; Craig Winstanley; Stephen Tuft; Rosanna Coates; Malcolm J. Horsburgh; Stephen Kaye
Tags: keratitis, staphylococcus aureus, treatment outcome, antimicrobials
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3410-3416. doi:https://doi.org/10.1167/iovs.12-11276
TREM-2 Promotes Host Resistance Against Pseudomonas aeruginosa Infection by Suppressing Corneal Inflammation via a PI3K/Akt Signaling Pathway Free
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Mingxia Sun; Min Zhu; Kang Chen; Xinxin Nie; Qiuchan Deng; Linda D. Hazlett; Yongjian Wu; Meiyu Li; Minhao Wu; Xi Huang
Tags: 1-phosphatidylinositol 3-kinase, cytokine, keratitis, phosphoinositide 3-kinase, trem2 gene
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3451-3462. doi:https://doi.org/10.1167/iovs.12-10938
Retinoic Acid Inhibits CD25+ Dendritic Cell Expansion and γδ T-Cell Activation in Experimental Autoimmune Uveitis Free
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Dongchun Liang; Aijun Zuo; Hui Shao; Willi K. Born; Rebecca L. O'Brien; Henry J. Kaplan; Deming Sun
Tags: antigens, cd25, t-cell activation, t-lymphocytes, tretinoin, autoimmune diseases
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3493-3503. doi:https://doi.org/10.1167/iovs.12-11432
Preclinical Study of Ublituximab, a Glycoengineered Anti-Human CD20 Antibody, in Murine Models of Primary Cerebral and Intraocular B-Cell Lymphomas Free
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Rym Ben Abdelwahed; Sabrina Donnou; Hanane Ouakrim; Lucile Crozet; Jérémie Cosette; Alexandra Jacquet; Isabel Tourais; Bénédicte Fournès; Mélanie Gillard Bocquet; Amine Miloudi; Valérie Touitou; Cécile Daussy; Marie-Christine Naud; Wolf Herman Fridman; Catherine Sautès-Fridman; Rémi Urbain; Sylvain Fisson
Tags: antibodies, b-cell lymphomas, brain, cd20 antigens, mice
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3657-3665. doi:https://doi.org/10.1167/iovs.12-10316

Low Vision

Dual Cognitive Task Affects Reaching and Grasping Behavior in Subjects With Macular Disorders Free
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Shahina Pardhan; Sander Zuidhoek
Tags: macular disorders, velocity
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3281-3288. doi:https://doi.org/10.1167/iovs.12-11045
Characteristics of On-Road Driving Performance of Persons With Central Vision Loss Who Use Bioptic Telescopes Free
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Joanne M. Wood; Gerald McGwin, Jr; Jennifer Elgin; Karen Searcey; Cynthia Owsley
Tags: blindness, telescope
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3790-3797. doi:https://doi.org/10.1167/iovs.12-11485

Multidisciplinary Ophthalmic Imaging

Choroidal Oximetry With a Noninvasive Spectrophotometric Oximeter Free
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Jona Valgerdur Kristjansdottir; Sveinn Hakon Hardarson; Andrew R. Harvey; Olof Birna Olafsdottir; Thorunn Scheving Eliasdottir; Einar Stefánsson
Tags: oximetry, oxygen analyzer, device, oxygen saturation measurement, hyperoxia, oxygen
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3234-3239. doi:https://doi.org/10.1167/iovs.12-10507
Individual A-Scan Signal Normalization Between Two Spectral Domain Optical Coherence Tomography Devices Free
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Chieh-Li Chen; Hiroshi Ishikawa; Gadi Wollstein; Yun Ling; Richard A. Bilonick; Larry Kagemann; Ian A. Sigal; Joel S. Schuman
Tags: noise, optical coherence tomography, glaucoma, nose
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3463-3471. doi:https://doi.org/10.1167/iovs.12-11484
Noninvasive Investigation of Deep Vascular Pathologies of Exudative Macular Diseases by High-Penetration Optical Coherence Angiography Free
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Young-Joo Hong; Masahiro Miura; Shuichi Makita; Myeong Jin Ju; Byeong Ha Lee; Takuya Iwasaki; Yoshiaki Yasuno
Tags: angiogram, choroidal neovascularization, face, macular disorders, optics
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3621-3631. doi:https://doi.org/10.1167/iovs.12-11184

Nantotechnology and Regenerative Medicine

A Fish Scale–Derived Collagen Matrix as Artificial Cornea in Rats: Properties and Potential Free
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T. Huibertus van Essen; Chien C. Lin; A. Karim Hussain; Saskia Maas; Horng J. Lai; Harold Linnartz; Thomas J. T. P. van den Berg; Daniela C. F. Salvatori; Gregorius P. M. Luyten; Martine J. Jager
Tags: collagen, cornea, rats, sutures, implantation procedure
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3224-3233. doi:https://doi.org/10.1167/iovs.13-11799

Physiology and Pharmacology

Perivascular Cells With Pericyte Characteristics Are Involved in ATP- and PGE2-Induced Relaxation of Porcine Retinal Arterioles In Vitro Free
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Mikkel Wölck Misfeldt; Simon Metz Mariendal Pedersen; Toke Bek
Tags: arteriole, body tissue, calcium, pericytes, suidae
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3258-3264. doi:https://doi.org/10.1167/iovs.13-11685

Retina

Coherent Anti-Stokes Raman Scattering (CARS) Microscopy: A Novel Technique for Imaging the Retina Free
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Omid Masihzadeh; David A. Ammar; Malik Y. Kahook; Tim C. Lei
Tags: diagnostic imaging, mice, retina, body tissue, lipids
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3094-3101. doi:https://doi.org/10.1167/iovs.13-11642
Localized Reticular Pseudodrusen and Their Topographic Relation to Choroidal Watershed Zones and Changes in Choroidal Volumes Free
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Florian Alten; Christoph R. Clemens; Peter Heiduschka; Nicole Eter
Tags: angiogram, choroid, diagnostic imaging, eye, phenotype
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3250-3257. doi:https://doi.org/10.1167/iovs.13-11923
Lectin Microarray Profiling and Relative Quantification of Glycome Associated With Proteins of Neonatal wt and rd1 Mice Retinae Free
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Satpal Ahuja
Tags: lectin, mice, polysaccharides, proteins, newborn
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3272-3280. doi:https://doi.org/10.1167/iovs.12-11363
Dexamethasone Intravitreal Implant for Treatment of Patients With Recalcitrant Macular Edema Resulting From Irvine-Gass Syndrome Free
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Marco Dutra Medeiros; Rafael Navarro; José Garcia-Arumí; Carlos Mateo; Borja Corcóstegui
Tags: dexamethasone, edema, intravitreal implants, syndrome, implants
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3320-3324. doi:https://doi.org/10.1167/iovs.12-11463
Changes in Choroidal Thickness in Relation to the Severity of Retinopathy and Macular Edema in Type 2 Diabetic Patients Free
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Jee Taek Kim; Dong Hoon Lee; Soo Geun Joe; June-Gone Kim; Young Hee Yoon
Tags: diabetes mellitus, diabetic retinopathy, edema, eye, nonproliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3378-3384. doi:https://doi.org/10.1167/iovs.12-11503
The Relationship Between Cord Blood Cytokine Levels and Perinatal Factors and Retinopathy of Prematurity: A Gestational Age-Matched Case-Control Study Free
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Se Joon Woo; Kyo Hoon Park; Sung Youn Lee; Seong Joon Ahn; Jeeyun Ahn; Kyu Hyung Park; Kyung Joon Oh; Aeli Ryu
Tags: cytokine, perinatal period, retinopathy of prematurity, umbilical cord blood, infant
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3434-3439. doi:https://doi.org/10.1167/iovs.13-11837
Retinal Ganglion Cell Damage in an Experimental Rodent Model of Blast-Mediated Traumatic Brain Injury Free
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Kabhilan Mohan; Helga Kecova; Elena Hernandez-Merino; Randy H. Kardon; Matthew M. Harper
Tags: basic local alignment search tool, blast injuries, mice, traumatic brain injuries, retinal ganglion cells
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3440-3450. doi:https://doi.org/10.1167/iovs.12-11522
Static and Flicker Perimetry in Age-Related Macular Degeneration Free
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Chi D. Luu; Peter N. Dimitrov; Zhichao Wu; Lauren N. Ayton; Galina Makeyeva; Khin-Zaw Aung; Mary Varsamidis; Luba Robman; Algis J. Vingrys; Robyn H. Guymer
Tags: age-related macular degeneration, perimetry, photopsia, eye
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3560-3568. doi:https://doi.org/10.1167/iovs.12-10465
Adaptive Optics Imaging of Geographic Atrophy Free
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Kiyoko Gocho; Valérie Sarda; Sabrina Falah; José-Alain Sahel; Florian Sennlaub; Mustapha Benchaboune; Martine Ullern; Michel Paques
Tags: atrophy, diagnostic imaging, optics
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3673-3680. doi:https://doi.org/10.1167/iovs.12-10672
Low-Intensity Far-Red Light Inhibits Early Lesions That Contribute to Diabetic Retinopathy: In Vivo and In Vitro Free
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Johnny Tang; Yunpeng Du; Chieh Allen Lee; Ramaprasad Talahalli; Janis T. Eells; Timothy S. Kern
Tags: cytochrome c oxidase, diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, glucose
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3681-3690. doi:https://doi.org/10.1167/iovs.12-11018
A Wide-Field Suprachoroidal Retinal Prosthesis Is Stable and Well Tolerated Following Chronic Implantation Free
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Joel Villalobos; David A. X. Nayagam; Penelope J. Allen; Penelope McKelvie; Chi D. Luu; Lauren N. Ayton; Alexia L. Freemantle; Michelle McPhedran; Meri Basa; Ceara C. McGowan; Robert K. Shepherd; Chris E. Williams
Tags: eye, implantation procedure, implants, safety, visual prosthesis
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3751-3762. doi:https://doi.org/10.1167/iovs.12-10843
Intravitreal Injection of Ranibizumab for Recovery of Macular Function in Eyes With Subfoveal Polypoidal Choroidal Vasculopathy Free
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Ken Ogino; Akitaka Tsujikawa; Kenji Yamashiro; Sotaro Ooto; Akio Oishi; Isao Nakata; Masahiro Miyake; Nagahisa Yoshimura
Tags: eye, intravitreal injections, macular function, ranibizumab, recovery of function
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3771-3779. doi:https://doi.org/10.1167/iovs.12-11494

Retinal Cell Biology

Retinoic Acid Promotes Apoptosis and Differentiation in Photoreceptors by Activating the P38 MAP Kinase Pathway Free
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Pablo De Genaro; M. Victoria Simón; Nora P. Rotstein; Luis E. Politi
Tags: apoptosis, mitogen-activated protein kinase p38, photoreceptors, tretinoin
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3143-3156. doi:https://doi.org/10.1167/iovs.12-11049
A Naturally Occurring Mouse Model of Achromatopsia: Characterization of the Mutation in Cone Transducin and Subsequent Retinal Phenotype Free
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Andrew I. Jobling; Kirstan A. Vessey; Michelle Waugh; Samuel A. Mills; Erica L. Fletcher
Tags: achromatopsia, mice, mutation, phenotype, retinal cone
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3350-3359. doi:https://doi.org/10.1167/iovs.13-11831
Two-Photon Microscopy and Fluorescence Lifetime Imaging of Retinal Pigment Epithelial Cells Under Oxidative Stress Free
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Yoko Miura; Gereon Huettmann; Regina Orzekowsky-Schroeder; Philipp Steven; Márta Szaszák; Norbert Koop; Ralf Brinkmann
Tags: diagnostic imaging, fluorescence, lasers, melanosomes, oxidative stress
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3366-3377. doi:https://doi.org/10.1167/iovs.13-11808
Aquaporin Expression and Function in Human Pluripotent Stem Cell–Derived Retinal Pigmented Epithelial Cells Free
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Kati Juuti-Uusitalo; Christine Delporte; Francoise Grégoire; Jason Perret; Heini Huhtala; Virpi Savolainen; Soile Nymark; Jari Hyttinen; Hannu Uusitalo; Francois Willermain; Heli Skottman
Tags: aquaporin 1, pluripotent stem cells, retinal pigment cell, water channels, epithelial cells
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3510-3519. doi:https://doi.org/10.1167/iovs.13-11800
SIK2 Is Involved in the Negative Modulation of Insulin-Dependent Müller Cell Survival and Implicated in Hyperglycemia-Induced Cell Death Free
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Gamze Küser-Abalı; Ferruh Ozcan; Asli Ugurlu; Avni Uysal; Stefan H. Fuss; Kuyas Bugra-Bilge
Tags: hyperglycemia, insulin, proto-oncogene proteins c-akt, cell death, cell survival
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3526-3537. doi:https://doi.org/10.1167/iovs.12-10729
A CNS-Specific Hypomorphic Pdgfr-Beta Mutant Model of Diabetic Retinopathy Free
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Shalini Jadeja; Richard L. Mort; Margaret Keighren; Alan W. Hart; Russell Joynson; Sara Wells; Paul K. Potter; Ian J. Jackson
Tags: diabetic retinopathy, mice, pericytes, platelet-derived growth factor beta receptor, redness of eye
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3569-3578. doi:https://doi.org/10.1167/iovs.12-11125
Human Photoreceptor Outer Segments Shorten During Light Adaptation Free
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Michael D. Abràmoff; Robert F. Mullins; Kyungmoo Lee; Jeremy M. Hoffmann; Milan Sonka; Douglas B. Critser; Steven F. Stasheff; Edwin M. Stone
Tags: electrooculography, light adaptation, photoreceptors, vitelliform dystrophy, eye
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3721-3728. doi:https://doi.org/10.1167/iovs.13-11812
Aβ-Induced Senescent Retinal Pigment Epithelial Cells Create a Proinflammatory Microenvironment in AMD Free
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Lining Cao; Hao Wang; Fang Wang; Ding Xu; Fang Liu; Chaoqi Liu
Tags: gelatinase b, retinal pigment cell, interleukin-8, aging
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3738-3750. doi:https://doi.org/10.1167/iovs.13-11612

Visual Neuroscience

Targeted Expression of Anoctamin Calcium-Activated Chloride Channels in Rod Photoreceptor Terminals of the Rodent Retina Free
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Kristin Dauner; Carolin Möbus; Stephan Frings; Frank Möhrlen
Tags: calcium, chloride channels, proteins, retina, rod photoreceptors
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3126-3136. doi:https://doi.org/10.1167/iovs.13-11711
ON and OFF Electroretinography and Contrast Sensitivity in Duchenne Muscular Dystrophy Free
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Mirella Telles Salgueiro Barboni; Balázs Vince Nagy; Ana Laura de Araújo Moura; Francisco Max Damico; Marcelo Fernandes da Costa; Jan Kremers; Dora Fix Ventura
Tags: contrast sensitivity, duchenne's muscular dystrophy, electroretinography
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3195-3204. doi:https://doi.org/10.1167/iovs.13-11700

Visual Psychophysics and Physiological Optics

Modified Monovision With Spherical Aberration to Improve Presbyopic Through-Focus Visual Performance Free
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Len Zheleznyak; Ramkumar Sabesan; Je-Sun Oh; Scott MacRae; Geunyoung Yoon
Tags: eye, image quality, vision, anisometropia, pupil
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3157-3165. doi:https://doi.org/10.1167/iovs.12-11050
Influence of Macular Pigment on Retinal Straylight in Healthy Eyes Free
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Sien Jongenelen; Jos J. Rozema; Marie-José Tassignon
Tags: eye, pigment
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3505-3509. doi:https://doi.org/10.1167/iovs.12-11441
The Continuum of Detection and Awareness of Visual Stimuli Within the Blindfield: From Blindsight to the Sighted-Sight Free
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Arash Sahraie; Ceri T. Trevethan; Mary-Joan MacLeod; Lawrence Weiskrantz; Amelia R. Hunt
Tags: hemianopsia, photic stimulation, training, vision
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3579-3585. doi:https://doi.org/10.1167/iovs.12-11231
Comparison of the Optical Image Quality in the Periphery of Phakic and Pseudophakic Eyes Free
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Bart Jaeken; Sandra Mirabet; José María Marín; Pablo Artal
Tags: eye, image quality, optics, astigmatism
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3594-3599. doi:https://doi.org/10.1167/iovs.13-11956
Wavelength Dependence of the Ocular Straylight Free
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Harilaos S. Ginis; Guillermo M. Perez; Juan M. Bueno; Alexandros Pennos; Pablo Artal
Tags: eye, optics, pigmentation, point spread function
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3702-3708. doi:https://doi.org/10.1167/iovs.13-11697

Perspective

Validating Retinal Fundus Image Analysis Algorithms: Issues and a Proposal Free
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Emanuele Trucco; Alfredo Ruggeri; Thomas Karnowski; Luca Giancardo; Edward Chaum; Jean Pierre Hubschman; Bashir al-Diri; Carol Y. Cheung; Damon Wong; Michael Abràmoff; Gilbert Lim; Dinesh Kumar; Philippe Burlina; Neil M. Bressler; Herbert F. Jelinek; Fabrice Meriaudeau; Gwénolé Quellec; Tom MacGillivray; Bal Dhillon
Tags: neuregulins
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3546-3559. doi:https://doi.org/10.1167/iovs.12-10347

Letters to the Editor

Author Response: Macular Migration Toward the Optic Disc After Inner Limiting Membrane Peeling for Diabetic Macular Edema Free
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Munemitsu Yoshikawa; Tomoaki Murakami
Tags: diabetic macular edema, optic disk, tissue membrane
Investigative Ophthalmology & Visual Science May 2013, Vol.54, 3504. doi:https://doi.org/10.1167/iovs.13-12215
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