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Research Highlight

Networks of Genes Governing the Development of Optic and Otic Vesicles: Implications for Eye and Ear Development Free
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Marc M. Abitbol
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 892. doi:https://doi.org/10.1167/iovs.15-16420
The Enigma of Luminance and Fixation in Dissociated Strabismus Free
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Zia Chaudhuri
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1088. doi:https://doi.org/10.1167/iovs.15-16404
Semaphorin 7a in Herpetic Neurotrophic Keratitis Free
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Deepak Shukla
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1108. doi:https://doi.org/10.1167/iovs.15-16473
Evidence for Nontraditional Lymphatics in the Choroid Free
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J. Steven Alexander; Felix Becker
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1328. doi:https://doi.org/10.1167/iovs.15-16491

Anatomy and Pathology/Oncology

Unaltered Retinal Dopamine Levels in a C57BL/6 Mouse Model of Form-Deprivation Myopia Free
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Xiao-Hua Wu; Yun-Yun Li; Ping-Ping Zhang; Kang-Wei Qian; Jian-Hua Ding; Gang Hu; Shi-Jun Weng; Xiong-Li Yang; Yong-Mei Zhong
Tags: dopamine, eye, mice, mice, inbred c57bl, myopia
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 967-977. doi:https://doi.org/10.1167/iovs.13-13362

Biochemistry and Molecular Biology

Evaluation of 12 Myopia-Associated Genes in Chinese Patients With High Myopia Free
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Jiali Li; Dan Jiang; Xueshan Xiao; Shiqiang Li; Xiaoyun Jia; Wenmin Sun; Xiangming Guo; Qingjiong Zhang
Tags: chinese (other dialects), genes, myopia, chinese people, dideoxy chain termination dna sequencing
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 722-729. doi:https://doi.org/10.1167/iovs.14-14880
Involvement of Intracellular Calcium Mobilization in IL-8 Activation in Human Retinal Pigment Epithelial Cells Free
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I-Hui Yang; Jhen-Hong Wong; Che-Mai Chang; Ben-Kuen Chen; Yao-Ting Tsai; Wei-Chiao Chen; Eric Terry Wang; Wen-Li Hsu; Wei-Chiao Chang
Tags: calcium, interleukin-8, retinal pigment cell
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 761-769. doi:https://doi.org/10.1167/iovs.14-15299
Pharmacokinetics of Bevacizumab and Its Effects on Serum VEGF and IGF-1 in Infants With Retinopathy of Prematurity Free
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Lingkun Kong; Amit R. Bhatt; Ann B. Demny; David K. Coats; Alexa. Li; Effie Z. Rahman; O'Brian E. Smith; Paul G. Steinkuller
Tags: bevacizumab, infant, insulin-like growth factor i, retinopathy of prematurity, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 956-961. doi:https://doi.org/10.1167/iovs.14-15842

Clinical and Epidemiologic Research

Association Between Body Composition and Retinal Vascular Caliber in Children and Adolescents Free
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Wei Xiao; Weifeng Gong; Qianyun Chen; Xiaohu Ding; Billy Chang; Mingguang He
Tags: adolescent, body composition, child, retinal vascular caliber, body mass index procedure
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 705-710. doi:https://doi.org/10.1167/iovs.14-14946
The Association of Longitudinal Trend of Fasting Plasma Glucose With Retinal Microvasculature in People Without Established Diabetes Free
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Yin Hu; Yong Niu; Dandan Wang; Ying Wang; Brien A. Holden; Mingguang He
Tags: diabetes mellitus, diabetes mellitus, type 2, fasting, plasma glucose, retinal vascular caliber
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 842-848. doi:https://doi.org/10.1167/iovs.14-15943
Self-Perceived Barriers to Eye Care in a Hard-to-Reach Population: The Karachi Marine Fishing Communities Eye and General Health Survey Free
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Khabir Ahmad; Anthony B. Zwi; Daniel J. M. Tarantola; Tanveer Anjum Chaudhry
Tags: community, eye, eye care, health surveys, ophthalmic examination and evaluation
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1023-1032. doi:https://doi.org/10.1167/iovs.14-16019
Prevalence and Racial Differences in Pterygium: A Cross-Sectional Study in Han and Uygur Adults in Xinjiang, China Free
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Ting Chen; Lin Ding; Guangliang Shan; Limujiang Ke; Jin Ma; Yong Zhong
Tags: prevalence, pterygium, china, risk factors, adult
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1109-1117. doi:https://doi.org/10.1167/iovs.14-15994
Age-Related Eye Disease and Cognitive Function Free
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Hanen Harrabi; Marie-Jeanne Kergoat; Jacqueline Rousseau; Hélène Boisjoly; Heidi Schmaltz; Solmaz Moghadaszadeh; Marie-Hélène Roy-Gagnon; Ellen E. Freeman
Tags: cognitive ability, eye diseases, glaucoma
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1217-1221. doi:https://doi.org/10.1167/iovs.14-15370
Factors Influencing the Output of Rural Cataract Surgical Facilities in China: The SHARP Study Free
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Tingting Chen; Ling Jin; Zhongqiang Zhou; Yiwen Huang; Xixi Yan; Tianyu Liu; Ee Lin Ong; Bin Liu; Wenyong Huang; Beatrice Iezzi; Mingguang He; David S. Friedman; Nathan G. Congdon
Tags: cataract, china, hospitals, surgical procedures, operative
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1283-1291. doi:https://doi.org/10.1167/iovs.14-16263

Cornea

Inhibition of RAP1 Enhances Corneal Recovery Following Alkali Injury Free
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Ming Wai Poon; Limeng Yan; Dan Jiang; Peng Qin; Hung-fat Tse; Ian Y. Wong; David S. H. Wong; Vinay Tergaonkar; Qizhou Lian
Tags: alkalies, cornea, wound healing, wounds and injuries, mice
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 711-721. doi:https://doi.org/10.1167/iovs.14-15268
Elevated Expression of Matrix Metalloproteinase-9 and Inflammatory Cytokines in Keratoconus Patients Is Inhibited by Cyclosporine A Free
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Rohit Shetty; Anuprita Ghosh; Rayne R. Lim; Murali Subramani; Krina Mihir; Reshma A. R; Ashwini Ranganath; Sriharsha Nagaraj; Rudy M. M. A. Nuijts; Roger Beuerman; Reshma Shetty; Debashish Das; Shyam S. Chaurasia; Abhijit Sinha-Roy; Arkasubhra Ghosh
Tags: cyclosporine, cytokine, gelatinase b, keratoconus, corneal epithelial cells
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 738-750. doi:https://doi.org/10.1167/iovs.14-14831
An Analysis of the Factors Influencing the Residual Refractive Astigmatism After Cataract Surgery With Toric Intraocular Lenses Free
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Giacomo Savini; Kristian Næser
Tags: astigmatism, cornea, intraocular lens implant device, eye
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 827-835. doi:https://doi.org/10.1167/iovs.14-15903
Infrared Imaging of Meibomian Glands and Evaluation of the Lipid Layer in Sjögren's Syndrome Patients and Nondry Eye Controls Free
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Kara L. Menzies; Sruthi Srinivasan; C. Lisa Prokopich; Lyndon Jones
Tags: diagnostic imaging, dry eye syndromes, eye, lipids, meibomian gland
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 836-841. doi:https://doi.org/10.1167/iovs.14-13864
Corneal Epithelial Wound Healing and Bactericidal Effect of Conditioned Medium From Human Uterine Cervical Stem Cells Free
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Maria A. Bermudez; Juan Sendon-Lago; Noemi Eiro; Mercedes Treviño; Francisco Gonzalez; Eva Yebra-Pimentel; Maria Jesus Giraldez; Manuel Macia; Maria Luz Lamelas; Jorge Saa; Francisco Vizoso; Roman Perez-Fernandez
Tags: cornea, culture media, conditioned, dry eye syndromes, epithelium, stem cells
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 983-992. doi:https://doi.org/10.1167/iovs.14-15859
Degeneration and Regeneration of Corneal Nerves in Response to HSV-1 Infection Free
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Ana J. Chucair-Elliott; Min Zheng; Daniel J. J. Carr
Tags: cornea, human herpesvirus 1, infections, neurons, reinnervation
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1097-1107. doi:https://doi.org/10.1167/iovs.14-15596
Cosmetic Preservatives as Therapeutic Corneal and Scleral Tissue Cross-Linking Agents Free
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Natasha Babar; MiJung Kim; Kerry Cao; Yukari Shimizu; Su-Young Kim; Anna Takaoka; Stephen L. Trokel; David C. Paik
Tags: body tissue, cornea, cross-linking, sclera, corneal collagen cross-linking
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1274-1282. doi:https://doi.org/10.1167/iovs.14-16035

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Saccadic Adaptation in Visually Normal Individuals Using Saccadic Endpoint Variability From Amblyopia Free
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Rana Arham Raashid; Agnes M. F. Wong; Alan Blakeman; Herbert C. Goltz
Tags: amblyopia, saccades, anisometropic amblyopia
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 947-955. doi:https://doi.org/10.1167/iovs.14-15812
Relative Roles of Luminance and Fixation in Inducing Dissociated Vertical Divergence Free
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Rafif Ghadban; Laura Liebermann; Lindsay D. Klaehn; Jonathan M. Holmes; Michael C. Brodsky
Tags: dissociated vertical deviation, luminance, eye
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1081-1087. doi:https://doi.org/10.1167/iovs.14-15843
Complex I Subunit Gene Therapy With NDUFA6 Ameliorates Neurodegeneration in EAE Free
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Venu Talla; Rajeshwari Koilkonda; Vittorio Porciatti; Vince Chiodo; Sanford L. Boye; William W. Hauswirth; John Guy
Tags: gene therapy, mice, mitochondria, nerve degeneration, optic nerve
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1129-1140. doi:https://doi.org/10.1167/iovs.14-15950
Accommodative Performance of Children With Unilateral Amblyopia Free
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Vivian Manh; Angela M. Chen; Kristina Tarczy-Hornoch; Susan A. Cotter; T. Rowan Candy
Tags: amblyopia, eye, child, visual accommodation
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1193-1207. doi:https://doi.org/10.1167/iovs.14-14948
Steady-State Contrast Response Functions Provide a Sensitive and Objective Index of Amblyopic Deficits Free
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Daniel H. Baker; Mathieu Simard; Dave Saint-Amour; Robert F. Hess
Tags: amblyopia, eye, steady state
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1208-1216. doi:https://doi.org/10.1167/iovs.14-15611
Near Heterophoria in Early Childhood Free
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Erin Babinsky; Vidhyapriya Sreenivasan; T. Rowan Candy
Tags: child, strabismus
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1406-1415. doi:https://doi.org/10.1167/iovs.14-14649

Genetics

Abrogation of HMX1 Function Causes Rare Oculoauricular Syndrome Associated With Congenital Cataract, Anterior Segment Dysgenesis, and Retinal Dystrophy Free
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Rachel L. Gillespie; Jill Urquhart; Simon C. Lovell; Susmito Biswas; Neil R. A. Parry; Daniel F. Schorderet; I. Chris Lloyd; Jill Clayton-Smith; Graeme C. Black
Tags: congenital abnormality, congenital cataract, mutation, proteins, retinal dystrophies
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 883-891. doi:https://doi.org/10.1167/iovs.14-15861
The −308G>A Polymorphism of the TNF Gene Is Associated With Proliferative Diabetic Retinopathy in Caucasian Brazilians With Type 2 Diabetes Free
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Luís F. C. Sesti; Daisy Crispim; Luís H. Canani; Evelise R. Polina; Jakeline Rheinheimer; Patrícia S. Carvalho; Jorge L. Gross; Kátia G. Santos
Tags: diabetes mellitus, diabetes mellitus, type 2, european continental ancestry group, genes, polymorphism
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1184-1190. doi:https://doi.org/10.1167/iovs.14-15758
RGS6: A Novel Gene Associated With Congenital Cataract, Mental Retardation, and Microcephaly in a Tunisian Family Free
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Manèl Chograni; Fowzan S. Alkuraya; Faouzi Maazoul; Imen Lariani; Habiba Chaabouni-Bouhamed
Tags: congenital cataract, family, genes, intellectual disability, microcephaly
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1261-1266. doi:https://doi.org/10.1167/iovs.14-15198

Glaucoma

Quality of Life of Caregivers of Children With Congenital Glaucoma: Development and Validation of a Novel Questionnaire (CarCGQoL) Free
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Vijaya K. Gothwal; Seelam Bharani; Anil K. Mandal
Tags: caregivers, child, glaucoma, congenital, quality of life, questionnaires
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 770-777. doi:https://doi.org/10.1167/iovs.14-15905
Angiotensin II as a Morphogenic Cytokine Stimulating Fibrogenesis of Human Tenon's Capsule Fibroblasts Free
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Huimin Shi; Yuyan Zhang; Shuhao Fu; Zhaozeng Lu; Wen Ye; Yiqin Xiao
Tags: angiotensin ii, fibroblasts, tenon's capsule, cytokine
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 855-864. doi:https://doi.org/10.1167/iovs.14-15301
Lamina Cribrosa Visibility Using Optical Coherence Tomography: Comparison of Devices and Effects of Image Enhancement Techniques Free
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Michaël J. A. Girard; Tin A. Tun; Rahat Husain; Sanchalika Acharyya; Benjamin A. Haaland; Xin Wei; Jean M. Mari; Shamira A. Perera; Mani Baskaran; Tin Aung; Nicholas G. Strouthidis
Tags: cribriform plate, diagnostic imaging, glaucoma, image enhancement, optical coherence tomography
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 865-874. doi:https://doi.org/10.1167/iovs.14-14903
Neuroprotective Effects of Transcription Factor Brn3b in an Ocular Hypertension Rat Model of Glaucoma Free
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Dorota L. Stankowska; Alena Z. Minton; Margaret A. Rutledge; Brett H. Mueller, II; Nitasha R. Phatak; Shaoqing He; Hai-Ying Ma; Michael J. Forster; Thomas Yorio; Raghu R. Krishnamoorthy
Tags: cytomegalovirus, eye, glaucoma, intraocular pressure, ocular hypertension
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 893-907. doi:https://doi.org/10.1167/iovs.14-15008
Agreement Among Spectral-Domain Optical Coherence Tomography, Standard Automated Perimetry, and Stereophotography in the Detection of Glaucoma Progression Free
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Sebastián A. Banegas; Alfonso Antón; Antonio Morilla-Grasa; Marco Bogado; Eleonora M. Ayala; Javier Moreno-Montañes
Tags: glaucoma, optical coherence tomography, perimetry, trend
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1253-1260. doi:https://doi.org/10.1167/iovs.14-14994
Intravitreal Delivery of Human NgR-Fc Decoy Protein Regenerates Axons After Optic Nerve Crush and Protects Ganglion Cells in Glaucoma Models Free
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Xingxing Wang; Jun Lin; Alexander Arzeno; Jin Young Choi; Juliann Boccio; Eric Frieden; Ajay Bhargava; George Maynard; James C. Tsai; Stephen M. Strittmatter
Tags: axon, glaucoma, optic nerve, proteins, ganglia
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1357-1366. doi:https://doi.org/10.1167/iovs.14-15472

Immunology and Microbiology

Immunomodulatory Effects of Galectin-1 on an IgE-Mediated Allergic Conjunctivitis Model Free
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Claudia Bosnic Mello; Lisandra Ramos; Alexandre Dantas Gimenes; Teresa Raquel de Moraes Andrade; Sonia Maria Oliani; Cristiane Damas Gil
Tags: allergic conjunctivitis, conjunctiva, galectin 1, immediate hypersensitivity, immunoglobulin e
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 693-704. doi:https://doi.org/10.1167/iovs.14-15100
Inhibition of T-Cell Activation by Retinal Pigment Epithelial Cells Derived From Induced Pluripotent Stem Cells Free
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Sunao Sugita; Hiroyuki Kamao; Yuko Iwasaki; Satoshi Okamoto; Tomoyo Hashiguchi; Kyoko Iseki; Naoko Hayashi; Michiko Mandai; Masayo Takahashi
Tags: cytokine, pluripotent stem cells, retinal pigment cell, t-cell activation, t-lymphocytes
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1051-1062. doi:https://doi.org/10.1167/iovs.14-15619
A New Small Molecule For Treating Inflammation and Chorioretinal Neovascularization in Relapsing-Remitting and Chronic Experimental Autoimmune Uveitis Free
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Maria Diedrichs-Möhring; Johann Leban; Stefan Strobl; Franz Obermayr; Gerhild Wildner
Tags: autoimmune diseases, autoimmunity, inflammation, neovascularization, pathologic, t-lymphocytes
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1147-1157. doi:https://doi.org/10.1167/iovs.14-15518

Lens

The Penny Pusher: A Cellular Model of Lens Growth Free
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Yanrong Shi; Alicia De Maria; Snježana Lubura; Hrvoje Šikić; Steven Bassnett
Tags: lens (device), lens, crystalline, epithelium, epithelial cells
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 799-809. doi:https://doi.org/10.1167/iovs.14-16028
Subfoveal Choroidal Thickness and Cataract: The Beijing Eye Study 2011 Free
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Lei Shao; Liang Xu; Jing Shang Zhang; Qi Sheng You; Chang Xi Chen; Ya Xing Wang; Jost B. Jonas; Wen Bin Wei
Tags: cataract, cataract, nuclear, cortical cataract, eye, subcapsular cataract
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 810-815. doi:https://doi.org/10.1167/iovs.14-15736
miRNA-181a Inhibits the Proliferation, Migration, and Epithelial–Mesenchymal Transition of Lens Epithelial Cells Free
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Ning Dong; Xin Tang; Bing Xu
Tags: epithelium, lens epithelial cell, micrornas, polar cataract, cyclooxygenase-2
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 993-1001. doi:https://doi.org/10.1167/iovs.14-15860
Calculation of Ophthalmic Viscoelastic Device–Induced Focus Shift During Femtosecond Laser–Assisted Cataract Surgery Free
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Carolina P. de Freitas; Florence Cabot; Fabrice Manns; William Culbertson; Sonia H. Yoo; Jean-Marie Parel
Tags: anterior chamber of eye, cataract surgery, eye, femtosecond pulsed lasers, lasers
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1222-1227. doi:https://doi.org/10.1167/iovs.14-15822
Assessing Age-Related Changes in the Biomechanical Properties of Rabbit Lens Using a Coaligned Ultrasound and Optical Coherence Elastography System Free
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Chen Wu; Zhaolong Han; Shang Wang; Jiasong Li; Manmohan Singh; Chih-hao Liu; Salavat Aglyamov; Stanislav Emelianov; Fabrice Manns; Kirill V. Larin
Tags: lens (device), lens, crystalline, magnetic resonance elastography, optics, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1292-1300. doi:https://doi.org/10.1167/iovs.14-15654

Low Vision

Major Depressive and Anxiety Disorders in Visually Impaired Older Adults Free
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Hilde P. A. van der Aa; Hannie C. Comijs; Brenda W. J. H. Penninx; Ger H. M. B. van Rens; Ruth M. A. van Nispen
Tags: anxiety, anxiety disorders, depressive disorders, older adult, prevalence
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 849-854. doi:https://doi.org/10.1167/iovs.14-15848

Multidisciplinary Ophthalmic Imaging

Papillomacular Bundle and Inner Retinal Thicknesses Correlate With Visual Acuity in Nonarteritic Anterior Ischemic Optic Neuropathy Free
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Gema Rebolleda; Carmen Sánchez-Sánchez; Julio J. González-López; Inés Contreras; Francisco J. Muñoz-Negrete
Tags: eye, nonarteritic anterior ischemic optic neuropathy, visual acuity, atrophy
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 682-692. doi:https://doi.org/10.1167/iovs.14-15314
Automated Retinal Topographic Maps Measured With Magnetic Resonance Imaging Free
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Jan-Willem M. Beenakker; Denis P. Shamonin; Andrew G. Webb; Gregorius P. M. Luyten; Berend C. Stoel
Tags: magnetic resonance imaging, maps, retina
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1033-1039. doi:https://doi.org/10.1167/iovs.14-15161
Small Fiber Peripheral Neuropathy in Wilson Disease: An In Vivo Documentation by Corneal Confocal Microscopy Free
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Giacomo Carlo Sturniolo; Daniela Lazzarini; Ottavia Bartolo; Marianna Berton; Andrea Leonardi; Iva Angela Fregona; Raffaele Parrozzani; Edoardo Midena
Tags: cornea, hepatolenticular degeneration, microscopy, confocal, neuropathy, small-fiber
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1390-1395. doi:https://doi.org/10.1167/iovs.14-15004

Nantotechnology and Regenerative Medicine

Canonical/β-Catenin Wnt Pathway Activation Improves Retinal Pigmented Epithelium Derivation From Human Embryonic Stem Cells Free
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Lyndsay L. Leach; David E. Buchholz; Vignesh P. Nadar; Stefan E. Lowenstein; Dennis O. Clegg
Tags: embryonic stem cells, epithelium, mitf protein, signal transduction, polymerase chain reaction
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1002-1013. doi:https://doi.org/10.1167/iovs.14-15835

Physiology and Pharmacology

Temperature Oscillations Drive Cycles in the Activity of MMP-2,9 Secreted by a Human Trabecular Meshwork Cell Line Free
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Stanley Ka-lok Li; Juni Banerjee; Christopher Jang; Amita Sehgal; Richard A. Stone; Mortimer M. Civan
Tags: body temperature, gelatinase a, gelatinase b, temperature, trabecular meshwork
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1396-1405. doi:https://doi.org/10.1167/iovs.14-15834

Retina

Adaptive Optics Microperimetry and OCT Images Show Preserved Function and Recovery of Cone Visibility in Macular Telangiectasia Type 2 Retinal Lesions Free
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Qinyun Wang; William S. Tuten; Brandon J. Lujan; Jennifer Holland; Paul S. Bernstein; Steven D. Schwartz; Jacque L. Duncan; Austin Roorda
Tags: optics, recovery of function, retinal cone, telangiectasis, eye
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 778-786. doi:https://doi.org/10.1167/iovs.14-15576
Knockout of αA-Crystallin Inhibits Ocular Neovascularization Free
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Qiong Xu; Yujing Bai; Lvzhen Huang; Peng Zhou; Wenzhen Yu; Mingwei Zhao
Tags: angiogenesis, choroidal neovascularization, crystallins, mice, neovascularization, pathologic
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 816-826. doi:https://doi.org/10.1167/iovs.14-14734
Choroidal Thickness in Geographic Atrophy Secondary to Age-Related Macular Degeneration Free
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Moritz Lindner; Athanasios Bezatis; Joanna Czauderna; Eva Becker; Christian K. Brinkmann; Steffen Schmitz-Valckenberg; Rolf Fimmers; Frank G. Holz; Monika Fleckenstein
Tags: age-related macular degeneration, atrophy, eye, choroid, monocarboxylic acid transporters
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 875-882. doi:https://doi.org/10.1167/iovs.14-14933
Delay in Retinal Photoreceptor Development in Very Preterm Compared to Term Infants Free
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Lejla Vajzovic; Adam L. Rothman; Du Tran-Viet; Michelle T. Cabrera; Sharon F. Freedman; Cynthia A. Toth
Tags: infant, photoreceptors
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 908-913. doi:https://doi.org/10.1167/iovs.14-16021
Correlation Between Ganglion Cell Layer Thinning and Poor Visual Function After Resolution of Diabetic Macular Edema Free
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Sophie Bonnin; Ramin Tadayoni; Ali Erginay; Pascale Massin; Bénédicte Dupas
Tags: diabetic macular edema, eye, ganglia, vision, diabetes mellitus
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 978-982. doi:https://doi.org/10.1167/iovs.14-15503
A Low-Molecular-Weight Oil Cleaner For Removal of Leftover Silicone Oil Intraocular Tamponade Free
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Yau Kei Chan; David Wong; Hiu Kwan Yeung; Ping Kwan Man; Ho Cheung Shum
Tags: body weight, emulsions, evaporation, eye, silicone oils
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1014-1022. doi:https://doi.org/10.1167/iovs.14-15061
Restoration of Foveal Thickness and Architecture After Macula-Off Retinal Detachment Repair Free
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Roberto dell'Omo; Davide Viggiano; Dario Giorgio; Mariaelena Filippelli; Roberto Di Iorio; Rocco Calo'; Michele Cardone; Michele Rinaldi; Ermanno dell'Omo; Ciro Costagliola
Tags: detached retina repairs, embryonic lethal mutation, eye, follow-up, fovea centralis
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1040-1050. doi:https://doi.org/10.1167/iovs.14-15633
Surface Engineering of Porous Silicon Microparticles for Intravitreal Sustained Delivery of Rapamycin Free
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Alejandra Nieto; Huiyuan Hou; Sang Woong Moon; Michael J. Sailor; William R. Freeman; Lingyun Cheng
Tags: cell-derived microparticles, pneumonia severity index, proliferation signal inhibitors, rapamycin, silicon
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1070-1080. doi:https://doi.org/10.1167/iovs.14-15997
Role of Soluble Vascular Endothelial Growth Factor Receptor Signaling and Other Factors or Cytokines in Central Retinal Vein Occlusion With Macular Edema Free
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Hidetaka Noma; Tatsuya Mimura; Kanako Yasuda; Masahiko Shimura
Tags: central retinal vein occlusion, cytokine, edema, ligands, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1122-1128. doi:https://doi.org/10.1167/iovs.14-15789
Factors Associated With Persistent Subfoveal Fluid and Complete Macular Hole Closure in the PIONEER Study Free
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Justis P. Ehlers; Yuji Itoh; Lucy T. Xu; Peter K. Kaiser; Rishi P. Singh; Sunil K. Srivastava
Tags: intraoperative care, macular holes, persistence, surgical procedures, operative, visual acuity
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1141-1146. doi:https://doi.org/10.1167/iovs.14-15765
Relationship of Retinal Morphology and Retinal Sensitivity in the Treatment of Neovascular Age-Related Macular Degeneration Using Aflibercept Free
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Florian Sulzbacher; Philipp Roberts; Marion R. Munk; Alexandra Kaider; Maria Elisabeth Kroh; Stefan Sacu; Ursula Schmidt-Erfurth; for the Vienna Eye Study Center
Tags: aflibercept, exudative age-related macular degeneration, language morphology, morphology
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1158-1167. doi:https://doi.org/10.1167/iovs.14-14298
Activation of Liver X Receptor Protects Inner Retinal Damage Induced by N-methyl-D-aspartate Free
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Shijie Zheng; Hongxia Yang; Zihe Chen; Changwei Zheng; Chunyan Lei; Bo Lei
Tags: n-methylaspartate, liver x receptors
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1168-1180. doi:https://doi.org/10.1167/iovs.14-15612
The Effect of AMA0428, a Novel and Potent ROCK Inhibitor, in a Model of Neovascular Age-Related Macular Degeneration Free
PDF
Karolien Hollanders; Tine Van Bergen; Nele Kindt; Karolien Castermans; Dirk Leysen; Evelien Vandewalle; Lieve Moons; Ingeborg Stalmans
Tags: choroidal neovascularization, exudative age-related macular degeneration, fibrosis, inflammation, mice
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1335-1348. doi:https://doi.org/10.1167/iovs.14-15681
Retinal Ganglion Cells Thinning in Eyes With Nonproliferative Idiopathic Macular Telangiectasia Type 2A Free
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Jay Chhablani; Harsha B. Rao; Viquar Unnisa Begum; Ganesh Babu Jonnadulla; Ashwin Goud; Giulio Barteselli
Tags: eye, retinal ganglion cells, telangiectasis, retinal nerve fiber layer, tissue degeneration
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1416-1422. doi:https://doi.org/10.1167/iovs.14-15672

Retinal Cell Biology

Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens Free
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Diego J. Valdez; Paula S. Nieto; Natalia S. Della Costa; Clemar Schurrer; Mario E. Guido
Tags: aves, blindness, chickens, pupil, blue light
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 730-737. doi:https://doi.org/10.1167/iovs.14-15481
Oxytocin Expression and Function in the Posterior Retina: A Novel Signaling Pathway Free
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Patrick Halbach; De-Ann M. Pillers; Nathaniel York; Matti P. Asuma; Michelle A. Chiu; Wenxiang Luo; Sara Tokarz; Ian M. Bird; Bikash R. Pattnaik
Tags: macaca mulatta, oxytocin, oxytocin receptor, retina, signal pathway
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 751-760. doi:https://doi.org/10.1167/iovs.14-15646
Loss of Citron Kinase Affects a Subset of Progenitor Cells That Alters Late but Not Early Neurogenesis in the Developing Rat Retina Free
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Devi Krishna Priya Karunakaran; Nisarg Chhaya; Christopher Lemoine; Sean Congdon; Amye Black; Rahul Kanadia
Tags: neural development, phosphotransferases, retina, stem cells, embryo
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 787-798. doi:https://doi.org/10.1167/iovs.14-15272
Microarray Analysis of Gene Expression in Fibrovascular Membranes Excised From Patients With Proliferative Diabetic Retinopathy Free
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Keijiro Ishikawa; Shigeo Yoshida; Yoshiyuki Kobayashi; Yedi Zhou; Takahito Nakama; Shintaro Nakao; Yukio Sassa; Yuji Oshima; Hiroaki Niiro; Koichi Akashi; Toshihiro Kono; Tatsuro Ishibashi
Tags: gene expression, gene expression profiling, genes, proliferative diabetic retinopathy, proteins
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 932-946. doi:https://doi.org/10.1167/iovs.14-15589
Assessment of Retinal Function and Morphology in Aging Ccl2 Knockout Mice Free
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Kirstan A. Vessey; Michelle Waugh; Andrew I. Jobling; Joanna A. Phipps; Tracy Ho; Lidia Trogrlic; Ursula Greferath; Erica L. Fletcher
Tags: mice, monocyte chemoattractant protein-1, language morphology, morphology
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1238-1252. doi:https://doi.org/10.1167/iovs.14-15334
DNA Damage, Poly(ADP-Ribose) Polymerase Activation, and Phosphorylated Histone H2AX Expression During Postnatal Retina Development in C57BL/6 Mouse Free
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David Martín-Oliva; Sandra M. Martín-Guerrero; Ana M. Matia-González; Rosa M. Ferrer-Martín; María Martín-Estebané; María-Carmen Carrasco; Ana Sierra; José L. Marín-Teva; Ruth Calvente; Julio Navascués; Miguel A. Cuadros
Tags: dna damage, mice, retina, adenosine diphosphate ribose, poly(adp-ribose) polymerases
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1301-1309. doi:https://doi.org/10.1167/iovs.14-15828
Evidence for Lymphatics in the Developing and Adult Human Choroid Free
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Mark E. Koina; Louise Baxter; Samuel J. Adamson; Frank Arfuso; Ping Hu; Michele C. Madigan; Tailoi Chan-Ling
Tags: choroid, lymphatic vessels, lymphatic system, adult
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1310-1327. doi:https://doi.org/10.1167/iovs.14-15705
Identification of p58IPK as a Novel Neuroprotective Factor for Retinal Neurons Free
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Evgenii Boriushkin; Joshua J. Wang; Junhua Li; Guangjun Jing; Gail M. Seigel; Sarah X. Zhang
Tags: apoptosis, cyclophosphamide, doxorubicin, prednisone, and vincristine, mice, neurons, n-methylaspartate
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1374-1386. doi:https://doi.org/10.1167/iovs.14-15196

Visual Neuroscience

Temporal Summation in Children With a History of Retinopathy of Prematurity Free
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Ronald M. Hansen; Anne Moskowitz; Jena L. Tavormina; Jennifer N. Bush; Garima Soni; Anne B. Fulton
Tags: child, medical history, retinopathy of prematurity, temporal summation
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 914-917. doi:https://doi.org/10.1167/iovs.14-16102
Test–Retest Reliability of Hemifield, Central-Field, and Full-Field Chromatic Pupillometry for Assessing the Function of Melanopsin-Containing Retinal Ganglion Cells Free
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Shaobo Lei; Herbert C. Goltz; Manokaraananthan Chandrakumar; Agnes M. F. Wong
Tags: melanopsin, pupillometry, reliability, retinal ganglion cells, pupil reaction
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1267-1273. doi:https://doi.org/10.1167/iovs.14-15945
The Role of B Cells in the Early Onset of the First Demyelinating Event of Acute Optic Neuritis Free
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Anna Feldman; Michael Gurevich; Ruth Huna-Baron; Anat Achiron
Tags: b-lymphocytes, cd19 antigens, optic neuritis, gene expression, genes
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1349-1356. doi:https://doi.org/10.1167/iovs.14-15408
Voriconazole, an Antifungal Triazol That Causes Visual Side Effects, Is an Inhibitor of TRPM1 and TRPM3 Channels Free
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Wei-Hong Xiong; R. Lane Brown; Brian Reed; Neal S. Burke; Robert M. Duvoisin; Catherine W. Morgans
Tags: voriconazole, antifungal agents, electroretinography, adverse effects
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1367-1373. doi:https://doi.org/10.1167/iovs.14-15270

Visual Psychophysics and Physiological Optics

Location of Achromatizing Pupil Position and First Purkinje Reflection in a Normal Population Free
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Silvestre Manzanera; Pedro M. Prieto; Antonio Benito; Juan Tabernero; Pablo Artal
Tags: eye, pupil, acyl carrier protein, ataxic cerebral palsy, cycloleucine
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 962-966. doi:https://doi.org/10.1167/iovs.14-16108
Retinal Adaptation Abnormalities in Primary Open-Angle Glaucoma Free
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Mitchell Dul; Robert Ennis; Shira Radner; Barry Lee; Qasim Zaidi
Tags: glaucoma, open-angle glaucoma
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1329-1334. doi:https://doi.org/10.1167/iovs.14-15725

Clinical Trials

Implantation of a Novel Telemetric Intraocular Pressure Sensor in Patients With Glaucoma (ARGOS Study): 1-Year Results Free
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Antonis Koutsonas; Peter Walter; Gernot Roessler; Niklas Plange
Tags: glaucoma, implantation procedure, intraocular pressure, sensor
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1063-1069. doi:https://doi.org/10.1167/iovs.14-14925
Cyclocoagulation of the Ciliary Bodies by High-Intensity Focused Ultrasound: A 12-Month Multicenter Study Free
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Philippe Denis; Florent Aptel; Jean-François Rouland; Jean-Philippe Nordmann; Yves Lachkar; Jean-Paul Renard; Eric Sellem; Christophe Baudouin; Alain Bron
Tags: ciliary body, glaucoma, high-intensity focused ultrasound, intraocular pressure, multicenter studies
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1089-1096. doi:https://doi.org/10.1167/iovs.14-14973

Review

Advancing Therapeutic Strategies for Inherited Retinal Degeneration: Recommendations From the Monaciano Symposium Free
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Debra A. Thompson; Robin R. Ali; Eyal Banin; Kari E. Branham; John G. Flannery; David M. Gamm; William W. Hauswirth; John R. Heckenlively; Alessandro Iannaccone; K. Thiran Jayasundera; Naheed W. Khan; Robert S. Molday; Mark E. Pennesi; Thomas A. Reh; Richard G. Weleber; David N. Zacks; for the Monaciano Consortium
Tags: retinal degeneration, retinal dystrophies, gene therapy, universities, comprehension
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 918-931. doi:https://doi.org/10.1167/iovs.14-16049
Understanding the Process of Corneal Endothelial Morphological Change In Vitro Free
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Olivier Roy; Véronique Beaulieu Leclerc; Jean-Michel Bourget; Mathieu Thériault; Stéphanie Proulx
Tags: chronic exertional compartment syndrome, comprehension, cornea, corneal endothelium, endothelium
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1228-1237. doi:https://doi.org/10.1167/iovs.14-16166

Perspective

Smoking Causes Blindness: Time for Eye Care Professionals to Join the Fight Against Tobacco Free
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Tahgrid Asfar; Byron L. Lam; David J. Lee
Tags: blindness, eye care, smoking, tobacco
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1120-1121. doi:https://doi.org/10.1167/iovs.15-16479

Letters to the Editor

Changes of Choroidal Thickness After Phacoemulsification Free
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Miao He; Wenyong Huang
Tags: phacoemulsification
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1118. doi:https://doi.org/10.1167/iovs.14-15535
Author Response: Changes of Choroidal Thickness After Phacoemulsification Free
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Stéphanie Baillif; Alexandra Pierru
Tags: phacoemulsification
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1119. doi:https://doi.org/10.1167/iovs.14-16189
PRIMPOL Mutation: Functional Study Does Not Always Reveal the Truth Free
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Jiali Li; Qingjiong Zhang
Tags: mutation
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1181-1182. doi:https://doi.org/10.1167/iovs.14-16072
Author Response: PRIMPOL Mutation: Functional Study Does Not Always Reveal the Truth Free
PDF
Benjamin A. Keen; Laura J. Bailey; Stanislaw K. Jozwiakowski; Aidan J. Doherty
Tags: mutation
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1183. doi:https://doi.org/10.1167/iovs.14-16123
Two-Photon Fluorescence Microscopy of Corneal Riboflavin Absorption Through an Intact Epithelium Free
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Daniel M. Gore; Paul French; David O'Brart; Chris Dunsby; Bruce D. Allan
Tags: cornea, epithelium, microscopy, fluorescence, photons, process of absorption
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1191-1192. doi:https://doi.org/10.1167/iovs.15-16457
Postnatal Overexpression of the Human ARMS2 Gene Does Not Induce Abnormalities in Retina and Choroid in Transgenic Mouse Models Free
PDF
Ju Liu; Josephine Hoh
Tags: choroid, genes, mice, transgenic, protein overexpression, retina
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1387-1388. doi:https://doi.org/10.1167/iovs.14-15914
Author Response: Postnatal Overexpression of the Human ARMS2 Gene Does Not Induce Abnormalities in Retina and Choroid in Transgenic Mouse Models Free
PDF
Takeshi Iwata
Tags: choroid, genes, mice, transgenic, protein overexpression, retina
Investigative Ophthalmology & Visual Science February 2015, Vol.56, 1389. doi:https://doi.org/10.1167/iovs.14-16174
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