Volume 60 Issue 6 | IOVS

A Murine Model of Acute Allergic Conjunctivitis Induced by Continuous Exposure to Particulate Matter 2.5 Open Access

Yu-Jun Tang; Han-Hsin Chang; Chun-Yi Chiang; Chane-Yu Lai; Min-Yen Hsu; King-Rong Wang; Hsin-Hsuan Han; Ling-Yun Chen; David Pei-Cheng Lin

Tags: allergic conjunctivitis, conjunctiva, lichtenberg figures, mice, particulate matter

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2118-2126. doi:https://doi.org/10.1167/iovs.18-26214

Biochemistry and Molecular Biology

REDD1 Activates a ROS-Generating Feedback Loop in the Retina of Diabetic Mice Open Access

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William P. Miller; Allyson L. Toro; Alistair J. Barber; Michael D. Dennis

Tags: diabetes mellitus, feedback, mice, oxidative stress, retina

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2369-2379. doi:https://doi.org/10.1167/iovs.19-26606

Clinical and Epidemiologic Research

Vitreomacular Interface Abnormalities and Glaucoma in an Elderly Population (The MONTRACHET Study) Open Access

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Julie Blanc; Alassane Seydou; Inès Ben Ghezala; Clémence Deschasse; Cyril Meillon; Alain M. Bron; Christine Binquet; Catherine Creuzot-Garcher

Tags: glaucoma, older adult

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1996-2002. doi:https://doi.org/10.1167/iovs.18-26510

Factors Associated With Retinal Vessel Diameters in an Elderly Population: the Thessaloniki Eye Study Open Access

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Nikolaos Dervenis; Anne L. Coleman; Alon Harris; M. Roy Wilson; Fei Yu; Eleftherios Anastasopoulos; Panayiota Founti; Theofanis Pappas; Vassilis Kilintzis; Fotis Topouzis

Tags: eye, older adult, retinal vessels, cardiovascular diseases, medical history

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2208-2217. doi:https://doi.org/10.1167/iovs.18-26276

Cornea

Enhancing Rose Bengal-Photosensitized Protein Crosslinking in the Cornea Open Access

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Christian M. Wertheimer; Carolin Elhardt; Steffen M. Kaminsky; Linh Pham; Qing Pei; Bryan Mendes; Sepideh Afshar; Irene E. Kochevar

Tags: cornea, oxygen, phototoxic dermatitis, proteins, rose bengal

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1845-1852. doi:https://doi.org/10.1167/iovs.19-26604

Relationship Between Sleep and Symptoms of Tear Dysfunction in Singapore Malays and Indians Open Access

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Elizabeth Wen Ling Lim; Miao Li Chee; Charumathi Sabanayagam; Shivani Majithia; Yijin Tao; Tien Yin Wong; Ching-Yu Cheng; Louis Tong

Tags: dry eye syndromes, signs and symptoms, singapore, sleep, pathophysiology

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1889-1897. doi:https://doi.org/10.1167/iovs.19-26810

The Application of Strip Meniscometry to the Evaluation of Tear Volume in Mice Open Access

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Megumi Shinzawa; Murat Dogru; Keiichi Miyasaka; Takashi Kojima; Kazuo Tsubota

Tags: mice, stress, volume, dry eye syndromes

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2088-2091. doi:https://doi.org/10.1167/iovs.19-26850

Automated Measurement of Tear Meniscus Height with the Kowa DR-1α Tear Interferometer in Both Healthy Subjects and Dry Eye Patients Open Access

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Reiko Arita; Katsumi Yabusaki; Taisuke Hirono; Takanori Yamauchi; Tadashi Ichihashi; Shima Fukuoka; Naoyuki Morishige

Tags: dry eye syndromes, joint meniscus

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2092-2101. doi:https://doi.org/10.1167/iovs.18-24850

Riboflavin Concentrations at the Endothelium During Corneal Cross-Linking in Humans Open Access

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Theo G. Seiler; Ana Batista; Beatrice E. Frueh; Karsten Koenig

Tags: cornea, corneal collagen cross-linking, endothelium, riboflavin, mass or substance concentration per volume

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2140-2145. doi:https://doi.org/10.1167/iovs.19-26686

Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome Open Access

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Mathias Kaurstad Morthen; Sara Tellefsen; Stephen M. Richards; Scott M. Lieberman; Raheleh Rahimi Darabad; Wendy R. Kam; David A. Sullivan

Tags: androgens, autoimmunity, gene expression, genes, mice

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2181-2197. doi:https://doi.org/10.1167/iovs.19-26815

Human Meibum Cholesteryl and Wax Ester Variability With Age, Sex, and Meibomian Gland Dysfunction Open Access

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Douglas Borchman; Aparna Ramasubramanian; Gary N. Foulks

Tags: cohort studies, esters, meibomian gland, pathophysiology, donors

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2286-2293. doi:https://doi.org/10.1167/iovs.19-26812

A Mathematical Model of Corneal Metabolism in the Presence of an Iris-Fixated Phakic Intraocular Lens Open Access

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Peyman Davvalo Khongar; Jan O. Pralits; Xi Cheng; Peter Pinsky; Paolo Soleri; Rodolfo Repetto

Tags: cornea, glucose, intraocular lens implant device, iris fixation, metabolism

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2311-2320. doi:https://doi.org/10.1167/iovs.19-26624

MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells Open Access

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Kyu-Yeon Han; Jin-Hong Chang; Dimitri T. Azar

Tags: exosomes, endothelial cells, proteins

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2321-2329. doi:https://doi.org/10.1167/iovs.18-26277

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Peripapillary and Macular Vessel Density in Dysthyroid Optic Neuropathy: An Optical Coherence Tomography Angiography Study Open Access

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Te Zhang; Wei Xiao; Huijing Ye; Rongxin Chen; Yuxiang Mao; Huasheng Yang

Tags: angiogram, eye, optic nerve disorders, optical coherence tomography, vision

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1863-1869. doi:https://doi.org/10.1167/iovs.18-25941

Threshold Static Automated Perimetry of the Full Visual Field in Idiopathic Intracranial Hypertension Open Access

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Michael Wall; Ashwin Subramani; Luke X. Chong; Ramon Galindo; Andrew Turpin; Randy H. Kardon; Matthew J. Thurtell; Jane A. Bailey; Ivan Marin-Franch

Tags: blindness, perimetry, pseudotumor cerebri, visual fields, scotoma

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1898-1905. doi:https://doi.org/10.1167/iovs.18-26252

Electrophysiological and Psychophysical Studies of Meridional Anisotropies in Children With and Without Astigmatism Open Access

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Tiong Peng Yap; Chi D. Luu; Catherine M. Suttle; Audrey Chia; Mei Ying Boon

Tags: anisotropy, astigmatism, child, evoked potentials, visual, meridians

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1906-1913. doi:https://doi.org/10.1167/iovs.18-25924

Increased ER Stress After Experimental Ischemic Optic Neuropathy and Improved RGC and Oligodendrocyte Survival After Treatment With Chemical Chaperon Open Access

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Varun Kumar; Louise Alessandra Mesentier-Louro; Angela Jinsook Oh; Kathleen Heng; Mohammad Ali Shariati; Haoliang Huang; Yang Hu; Yaping Joyce Liao

Tags: cyclophosphamide, doxorubicin, prednisone, and vincristine, oligodendroglia, optic nerve, optic neuropathy, ischemic, stress

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1953-1966. doi:https://doi.org/10.1167/iovs.18-24890

Ocular Effects of Sildenafil in Naïve Mice and a Mouse Model of Optic Nerve Crush Open Access

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Alon Zahavi; Shirel Weiss; Mark Vieyra; James D. Nicholson; Orkun Muhsinoglu; Orit Barinfeld; David Zadok; Nitza Goldenberg-Cohen

Tags: mice, optic nerve, sildenafil, retina

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1987-1995. doi:https://doi.org/10.1167/iovs.18-26333

Indirect Traumatic Optic Neuropathy in Mild Chronic Traumatic Brain Injury Open Access

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Jane W. Chan; Nancy K. Hills; Benjamin Bakall; Brian Fernandez

Tags: craniocerebral trauma, eye, optic nerve injuries, traumatic brain injuries, traumatic brain injury, mild

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2005-2011. doi:https://doi.org/10.1167/iovs.18-26094

Reading Individual Words Within Sentences in Infantile Nystagmus Open Access

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Esha Prakash; Rebecca J. McLean; Sarah J. White; Kevin B. Paterson; Irene Gottlob; Frank A. Proudlock

Tags: pathologic nystagmus, reading (activity), sentences

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2226-2236. doi:https://doi.org/10.1167/iovs.18-25793

Head and Gaze Behavior in Retinitis Pigmentosa Open Access

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Samuel A. Titchener; Lauren N. Ayton; Carla J. Abbott; James B. Fallon; Mohit N. Shivdasani; Emily Caruso; Pyrawy Sivarajah; Matthew A. Petoe

Tags: eye, gaze, head movements, retinitis pigmentosa, saccades

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2263-2273. doi:https://doi.org/10.1167/iovs.18-26121

Genetics

Extending the Spectrum of EYS-Associated Retinal Disease to Macular Dystrophy Open Access

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Laurence H. M. Pierrache; Muriël Messchaert; Alberta A. H. J. Thiadens; Lonneke Haer-Wigman; Yvonne de Jong-Hesse; Wendy A. G. van Zelst-Stams; Rob W. J. Collin; Caroline C. W. Klaver; L. Ingeborgh van den Born

Tags: genotype, macular dystrophy, phenotype, retinal diseases, vision

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2049-2063. doi:https://doi.org/10.1167/iovs.18-25531

Characteristic Ocular Features in Cases of Autosomal Recessive PROM1 Cone-Rod Dystrophy Open Access

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Frederick T. Collison; Gerald A. Fishman; Takayuki Nagasaki; Jana Zernant; J. Jason McAnany; Jason C. Park; Rando Allikmets

Tags: autosomal recessive inheritance, diagnostic imaging, electroretinography, progressive cone-rod dystrophy, retinitis pigmentosa

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2347-2356. doi:https://doi.org/10.1167/iovs.19-26993

Glaucoma

Optic Disc Microhemorrhage in Primary Open-Angle Glaucoma: Clinical Implications for Visual Field Progression Open Access

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Ahnul Ha; Young Kook Kim; Sung Uk Baek; Ki Ho Park; Jin Wook Jeoung

Tags: glaucoma, microbiology procedures, microbleed, open-angle glaucoma, optic disk

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1824-1832. doi:https://doi.org/10.1167/iovs.19-26673

Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma Open Access

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Gaurang C. Patel; J. Cameron Millar; Abbot F. Clark

Tags: glaucoma, glucocorticoid receptors, glucocorticoids, medication therapy management, mice

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1967-1978. doi:https://doi.org/10.1167/iovs.18-26383

Lycium Barbarum Polysaccharides Rescue Neurodegeneration in an Acute Ocular Hypertension Rat Model Under Pre- and Posttreatment Conditions Open Access

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Yamunadevi Lakshmanan; Francisca Siu-Yin Wong; Wing-Yan Yu; Serena Zhe-Chuang Li; Kai-Yip Choi; Kwok-Fai So; Henry Ho-Lung Chan

Tags: electroretinography, nerve degeneration, ocular hypertension, polysaccharides, optical coherence tomography

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2023-2033. doi:https://doi.org/10.1167/iovs.19-26752

Transforming Growth Factor-β1–induced Human Subconjunctival Fibrosis is Mediated by MicroRNA 143/145 Expression Open Access

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Young Hoon Hwang; Sun-Ah Jung; Jungmook Lyu; Yong Yeon Kim; Joon H. Lee

Tags: micrornas, fibrosis

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2064-2071. doi:https://doi.org/10.1167/iovs.19-26797

Effects of Salidroside on Trabecular Meshwork Cell Extracellular Matrix Expression and Mouse Intraocular Pressure Open Access

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Yuchen Fan; Li Guo; Jiahong Wei; Junzhao Chen; Hao Sun; Tao Guo

Tags: extracellular matrix, intraocular pressure, mice, trabecular meshwork, ocular hypertension

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2072-2082. doi:https://doi.org/10.1167/iovs.19-26585

Optic Disc Tilt and Glaucoma Progression in Myopic Glaucoma: A Longitudinal Match-Pair Case-Control Study Open Access

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Bo Ram Seol; Ki Ho Park; Jin Wook Jeoung

Tags: glaucoma, optic disk, eye, tilted optic disc

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2127-2133. doi:https://doi.org/10.1167/iovs.18-25839

Choroidal Microvascular Dropout in Pseudoexfoliation Glaucoma Open Access

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Zia S. Pradhan; Harsha L. Rao; Shivani Dixit; Shruthi Sreenivasaiah; Praveena G. Reddy; Jayasree P. Venugopal; Narendra K. Puttaiah; Sathi Devi; Robert N. Weinreb; Kaweh Mansouri; Carroll A. B. Webers

Tags: exfoliation syndrome, eye, glaucoma, open-angle glaucoma, optic disk

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2146-2151. doi:https://doi.org/10.1167/iovs.19-26844

Impact of Posterior Sclera on Glaucoma Progression in Treated Myopic Normal-Tension Glaucoma Using Reconstructed Optical Coherence Tomographic Images Open Access

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Yong Chan Kim; Yong Ho Koo; Kyoung In Jung; Chan Kee Park

Tags: glaucoma, low tension glaucoma, optical coherence tomography, sclera, eye

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2198-2207. doi:https://doi.org/10.1167/iovs.19-26794

Anterior Segment Features in Nanophthalmos With Secondary Chronic Angle Closure Glaucoma: An Ultrasound Biomicroscopy Study Open Access

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Congcong Guo; Zhenni Zhao; Dandan Zhang; Jiafan Liu; Jianlong Li; Jiamin Zhang; Nannan Sun; Denghui Chen; Miao Zhang; Zhigang Fan

Tags: angle closure glaucoma, eye, glaucoma, microphthalmos, ultrasound biomicroscopy

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2248-2256. doi:https://doi.org/10.1167/iovs.19-26867

Immunology and Microbiology

Relationship Between Opacity of Cytomegalovirus Retinitis Lesion Borders and Severity of Immunodeficiency Among People With AIDS Open Access

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Gary N. Holland; Mark L. Van Natta; David T. Goldenberg; Rory Ritts Jr; Ronald P. Danis; Douglas A. Jabs; for the Studies of Ocular Complications of AIDS Research Group

Tags: acquired immunodeficiency syndrome, cytomegalovirus retinitis, immunologic deficiency syndromes

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1853-1862. doi:https://doi.org/10.1167/iovs.18-26517

TRPM1 Autoantibodies in Melanoma Patients Without Self-Reported Visual Symptoms Open Access

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Robert M. Duvoisin; Gaoying Ren; Tammie L. Haley; Matthew H. Taylor; Catherine W. Morgans

Tags: autoantibodies, malignant melanoma, cutaneous, melanoma, self-report, visual symptoms

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2330-2335. doi:https://doi.org/10.1167/iovs.19-26775

PD-L1/PD1 Expression, Composition of Tumor-Associated Immune Infiltrate, and HPV Status in Conjunctival Squamous Cell Carcinoma Open Access

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Priyadharsini Nagarajan; Christian El-Hadad; Stephen K. Gruschkus; Jing Ning; Courtney W. Hudgens; Oded Sagiv; Neil Gross; Michael T. Tetzlaff; Bita Esmaeli

Tags: conjunctiva, human papillomavirus, infiltrates, neoplasms, programmed cell death 1 ligand 1

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2388-2398. doi:https://doi.org/10.1167/iovs.19-26894

Lens

Depletion of Myo/Nog Cells in the Lens Mitigates Posterior Capsule Opacification in Rabbits Open Access

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Jacquelyn Gerhart; Liliana Werner; Nick Mamalis; Joseph Infanti; Colleen Withers; Fathma Abdalla; Colby Gerhart; Arturo Bravo-Nuevo; Olivia Gerhart; Lori Getts; Kelly Rhodes; Jessica Bowers; Robert Getts; Mindy George-Weinstein

Tags: after-cataract, cataract surgery, lens (device), lens, crystalline, oryctolagus cuniculus

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1813-1823. doi:https://doi.org/10.1167/iovs.19-26713

The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation Open Access

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Viviana M. Berthoud; Junyuan Gao; Peter J. Minogue; Oscar Jara; Richard T. Mathias; Eric C. Beyer

Tags: calcium, lens (device), lens, crystalline, cataract, mice

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2336-2346. doi:https://doi.org/10.1167/iovs.18-26459

Multidisciplinary Ophthalmic Imaging

Distances From Capillaries to Arterioles or Venules Measured Using OCTA and AOSLO Open Access

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Edmund Arthur; Ann E. Elsner; Kaitlyn A. Sapoznik; Joel A. Papay; Matthew S. Muller; Stephen A. Burns

Tags: arteriole, blood capillaries, venule, diameter

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1833-1844. doi:https://doi.org/10.1167/iovs.18-25294

Air-Puff-Induced Dynamics of Ocular Components Measured with Optical Biometry Open Access

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Ewa Maczynska; Jagoda Rzeszewska-Zamiara; Alfonso Jimenez Villar; Maciej Wojtkowski; Bartlomiej J. Kaluzny; Ireneusz Grulkowski

Tags: biometry, cornea, eye, intraocular pressure, optics

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1979-1986. doi:https://doi.org/10.1167/iovs.19-26681

Physiology and Pharmacology

Short-term High Fructose Intake Reprograms the Transcriptional Clock Rhythm of the Murine Extraorbital Lacrimal Gland Open Access

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Dingli Lu; Cuipei Lin; Xinwei Jiao; Zongming Song; Liya Wang; Jianqin Gu; Zhijie Li

Tags: diet, fructose, genes, mice, rhythm

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2038-2048. doi:https://doi.org/10.1167/iovs.18-26030

Ocular and Systemic Diurnal Rhythms in Emmetropic and Myopic Adults Open Access

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Hannah J. Burfield; Andrew Carkeet; Lisa A. Ostrin

Tags: adult, circadian rhythms, melatonin, intraocular pressure, light exposure

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2237-2247. doi:https://doi.org/10.1167/iovs.19-26711

Trabecular Meshwork TREK-1 Channels Function as Polymodal Integrators of Pressure and pH Open Access

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Oleg Yarishkin; Tam T. T. Phuong; David Križaj

Tags: mechanotransduction, cellular, protons, trabecular meshwork, synthetic cannabinoids, membrane potentials

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2294-2303. doi:https://doi.org/10.1167/iovs.19-26851

Tau Is Involved in Death of Retinal Ganglion Cells of Rats From Optic Nerve Crush Open Access

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Hidehiro Oku; Teruyo Kida; Taeko Horie; Koichiro Taki; Masashi Mimura; Shota Kojima; Tsunehiko Ikeda

Tags: optic nerve, tau proteins, retina, optic nerve injuries, rats

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2380-2387. doi:https://doi.org/10.1167/iovs.19-26683

Retina

Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology Open Access

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Virpi Alarautalahti; Symantas Ragauskas; Jenni J. Hakkarainen; Hannele Uusitalo-Järvinen; Hannu Uusitalo; Jari Hyttinen; Giedrius Kalesnykas; Soile Nymark

Tags: language morphology, mice, morphology, retina, tissue preparation

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1914-1927. doi:https://doi.org/10.1167/iovs.18-25156

Impact of Drusen Volume on Quantitative Fundus Autofluorescence in Early and Intermediate Age-Related Macular Degeneration Open Access

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Gregor Sebastian Reiter; Reinhard Told; Ferdinand Georg Schlanitz; Hrvoje Bogunovic; Lukas Baumann; Stefan Sacu; Ursula Schmidt-Erfurth; Andreas Pollreisz

Tags: age-related macular degeneration, drusen, fundus autofluorescence imaging, volume

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1937-1942. doi:https://doi.org/10.1167/iovs.19-26566

Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability Open Access

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Shinsuke Nakamura; Tetsuro Noguchi; Yuki Inoue; Shuji Sakurai; Anri Nishinaka; Yoshifumi Hida; Tomomi Masuda; Yasuhiro Nakagami; Naoto Horai; Hideshi Tsusaki; Hideaki Hara; Masamitsu Shimazawa

Tags: angiogenesis, cercopithecidae, choroidal neovascularization, lasers, mice

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1943-1952. doi:https://doi.org/10.1167/iovs.18-25745

Multimodal Imaging in Best Vitelliform Macular Dystrophy Open Access

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Jose Ronaldo Lima de Carvalho, Jr; Maarjaliis Paavo; Lijuan Chen; John Chiang; Stephen H. Tsang; Janet R. Sparrow

Tags: autofluorescence, eye, multimodal imaging, spectral domain-optical coherence tomography, vitelliform dystrophy

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2012-2022. doi:https://doi.org/10.1167/iovs.19-26571

The Relationship Between Retinal Vessel Oxygenation and Spatial Distribution of Retinal Nonperfusion in Retinal Vascular Diseases Open Access

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Luke Nicholson; Clara Vazquez-Alfageme; Philip G. Hykin; James W. Bainbridge; Sobha Sivaprasad

Tags: alveolar ventilation function, cell respiration, oximetry, retinal vascular disorders, retinal vessels

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2083-2087. doi:https://doi.org/10.1167/iovs.18-24917

Age-Related Scattered Hypofluorescent Spots on Late-Phase Indocyanine Green Angiography as Precursor Lesions of Polypoidal Choroidal Vasculopathy Open Access

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Ling Chen; Xiongze Zhang; Miaoling Li; Nanying Liao; Feng Wen

Tags: eye, indocyanine green angiography, polypoidal choroidal vasculopathy, spectral domain-optical coherence tomography, pathogenesis

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2102-2109. doi:https://doi.org/10.1167/iovs.19-26968

The Efemp1^R345W Macular Dystrophy Mutation Causes Amplified Circadian and Photophobic Responses to Light in Mice Open Access

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Stewart Thompson; Frederick R. Blodi; Demelza R. Larson; Michael G. Anderson; Steven F. Stasheff

Tags: macular dystrophy, melanopsin, mice, mutation, perceptual masking

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2110-2117. doi:https://doi.org/10.1167/iovs.19-26881

Intravitreal Fluocinolone Acetonide May Decelerate Diabetic Retinal Neurodegeneration Open Access

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Stephanie K. Lynch; Kyungmoo Lee; Zhi Chen; James C. Folk; Ursula Schmidt-Erfurth; Bianca S. Gerendas; Andreas Wahle; Charles C. Wykoff; Michael D. Abràmoff

Tags: cyclophosphamide/doxorubicin/fluorouracil protocol, diabetes mellitus, fluocinolone acetonide, left ventricular area fractional change, nerve degeneration

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2134-2139. doi:https://doi.org/10.1167/iovs.18-24643

Fluorescence Lifetimes in Patients With Hydroxychloroquine Retinopathy Open Access

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Yasmin Solberg; Chantal Dysli; Burkhard Möller; Sebastian Wolf; Martin S. Zinkernagel

Tags: fluorescence, hydroxychloroquine, retinal diseases

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2165-2172. doi:https://doi.org/10.1167/iovs.18-26079

Association of Systemic Inflammation With Retinal Vascular Caliber in Patients With AIDS Open Access

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Douglas A. Jabs; Mark L. Van Natta; Garrett Trang; Norman Jones; Jeffrey M. Milush; Ryan Cheu; Nichole R. Klatt; Jeong Won Pak; Ronald P. Danis; Peter W. Hunt

Tags: acquired immunodeficiency syndrome, inflammation, retinal vascular caliber, linear regression

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2218-2225. doi:https://doi.org/10.1167/iovs.18-26070

Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR Open Access

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Jakob Grauslund; Ulrik Frydkjaer-Olsen; Tunde Peto; Jimena Fernández-Carneado; Berta Ponsati; Cristina Hernández; José Cunha-Vaz; Rafael Simó; for the EUROCONDOR

Tags: brimonidine, diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, dilatation, pathologic

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2257-2262. doi:https://doi.org/10.1167/iovs.18-26487

Actin Dynamics, Regulated by RhoA-LIMK-Cofilin Signaling, Mediates Rod Photoreceptor Axonal Retraction After Retinal Injury Open Access

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Weiwei Wang; Eva Halasz; Ellen Townes-Anderson

Tags: actins, axon, microfilaments, retinal detachment, rhoa gtp-binding protein

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2274-2285. doi:https://doi.org/10.1167/iovs.18-26077

Retinal Cell Biology

The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1 Open Access

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Qianyi Luo; Yucheng Xiao; Alpha Alex; Theodore R. Cummins; Ashay D. Bhatwadekar

Tags: circadian rhythms, diabetes mellitus, diabetes mellitus, type 2, irs1 protein, human, mice

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1928-1936. doi:https://doi.org/10.1167/iovs.18-26045

Visual Neuroscience

Outer Retinal Structure and Function Deficits Contribute to Circadian Disruption in Patients With Type 2 Diabetes Open Access

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Sunila Dumpala; Andrew J. Zele; Beatrix Feigl

Tags: circadian rhythm disorders, diabetes mellitus, diabetes mellitus, type 2, melatonin, retina

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1870-1878. doi:https://doi.org/10.1167/iovs.18-26297

The Relationship Between the Photopic Negative Response and Retinal Ganglion Cell Topography Open Access

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Enyam Komla A. Morny; Kishan Patel; Marcela Votruba; Alison M. Binns; Tom H. Margrain

Tags: electroretinography, retinal cone, retinal ganglion cells, fovea centralis, waveforms

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1879-1887. doi:https://doi.org/10.1167/iovs.18-25272

Mouse Cones Adapt Fast, Rods Slowly In Vivo Open Access

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Anneka Joachimsthaler; Jan Kremers

Tags: luminance, mice, retinal cone, rod photoreceptors, electroretinography

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2152-2164. doi:https://doi.org/10.1167/iovs.18-26356

Wavelength Defocus and Temporal Sensitivity Affect Refractive Development in Guinea Pigs Open Access

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Tian Tian; Leilei Zou; Sujia Wu; Hong Liu; Rui Liu

Tags: blue light, caviidae, cornea, cues, green light

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2173-2180. doi:https://doi.org/10.1167/iovs.18-25228

Impact of Diabetic Retinopathy on Sleep, Mood, and Quality of Life Open Access

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Rupal Morjaria; Iona Alexander; Robert M. J. Purbrick; Rukhsana Safa; Ngaihang Victor Chong; Katharina Wulff; Russell G. Foster; Susan M. Downes; for the SOMNUS Study Group

Tags: diabetic retinopathy, mood, quality of life, sleep, sleep quality

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2304-2310. doi:https://doi.org/10.1167/iovs.18-26108

Visual Psychophysics and Physiological Optics

Perceptual Learning of Visual Span Improves Chinese Reading Speed Open Access

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Zhuoting Zhu; Yin Hu; Chimei Liao; Ren Huang; Stuart Keel; Yanping Liu; Mingguang He

Tags: chinese (other dialects), perceptual learning, reading (activity), reading speed, visual span

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2357-2368. doi:https://doi.org/10.1167/iovs.18-25780

Perspective

Antibodies Used to Detect Glaucoma-Associated Myocilin: More or Less Than Meets the Eye? Open Access

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Athéna C. Patterson-Orazem; Raquel L. Lieberman

Tags: antibodies, glaucoma, myoc gene, eye

Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2034-2037. doi:https://doi.org/10.1167/iovs.19-26843

Erratum

Erratum Open Access

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Investigative Ophthalmology & Visual Science May 2019, Vol.60, 1888. doi:https://doi.org/10.1167/iovs.18-25983a

Erratum Open Access

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Investigative Ophthalmology & Visual Science May 2019, Vol.60, 2003-2004. doi:https://doi.org/10.1167/iovs.18-25838a

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