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ARVO Annual Meeting Abstract June 2022

A new mode of gene therapy to subdue the limitations of the allotopic method: an analytic approach

sindhu velmurugan; Tsung-Han Chou; Jeremy D. Eastwood; Diego Alba; Vittorio Porciatti; John Guy; Hong Yu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2830 – A0346.

ARVO Annual Meeting Abstract June 2022

Leber Hereditary Optic Neuropathy Gene Therapy: Adverse Events and Visual Acuity Results of all Patient Groups

Byron L Lam; William J Feuer; Janet L Davis; Vittorio Porciatti; Hong Yu; Robert Levy; Elizabeth Vanner; John Guy

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1576 – A0365.

Articles March 2022

The Relationship Between Stage of Leber's Hereditary Optic Neuropathy and Pattern Electroretinogram Latency

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Vittorio Porciatti; Diego E. Alba; William J. Feuer; Janet Davis; John Guy; Byron L. Lam
TAGS: electroretinography, optic atrophy, hereditary, leber, steady state, eye
Trans. Vis. Sci. Tech.. 2022; 11(3):31. https://doi.org/10.1167/tvst.11.3.31

Includes: Supplemental Content

Articles October 2020

Mitochondrial Transfer of the Mutant Human ND6T14484C Gene Causes Visual Loss and Optic Neuropathy

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Hong Yu; David W. Sant; Gaofeng Wang; John Guy
TAGS: blindness, genes, mice, mitochondrial donation, optic atrophy, hereditary, leber, optic nerve disorders, carrying, injections
Trans. Vis. Sci. Tech.. 2020; 9(11):1. https://doi.org/10.1167/tvst.9.11.1

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology July 2020

XIAP Protects Retinal Ganglion Cells in the Mutant ND4 Mouse Model of Leber Hereditary Optic Neuropathy

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Sarah J. Wassmer; Yves De Repentigny; Derek Sheppard; Pamela S. Lagali; Lijun Fang; Stuart G. Coupland; Rashmi Kothary; John Guy; William W. Hauswirth; Catherine Tsilfidis
TAGS: birc4 gene, gene therapy, mice, optic atrophy, hereditary, leber, axon, retinal ganglion cells, optic nerve
Invest. Ophthalmol. Vis. Sci.. 2020; 61(8):49. https://doi.org/10.1167/iovs.61.8.49

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Kruppel-like factor (KLF4) knockout in retinal ganglion cells improves visual function in Experimental Autoimmune Encephalomyelitis (EAE) mice model of optic neuritis

Venu Talla; Rajeshwari D Koilkonda; John Guy

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1394.

ARVO Annual Meeting Abstract July 2019

Photoreceptor damage caused by human mutant T8993G ATP6 in a transgenic mouse model of Leigh syndrome and NARP

Huijun Yuan; John Guy

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):456.

ARVO Annual Meeting Abstract July 2019

Gene Therapy for Leber Hereditary Optic NeuropathY An update of Where We Stand (Clinicaltrials.gov number: NCT02161380)

John Guy; William Feuer; Janet L Davis; Vittorio Porciatti; Philip Gonzalez; Rajeshwari D Koilkonda; Huijun Yuan; Byron L Lam

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3602.

ARVO Annual Meeting Abstract July 2018

Novel NDUFV1 mutations with optic nerve atrophy

Zhike Zhang; Huijun Yuan; John Guy

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4140.

ARVO Annual Meeting Abstract July 2018

Mitochondrial transfer of the human ND6T14484C gene causes visual loss and optic neuropathy

Hong Yu; John Guy

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4538.

ARVO Annual Meeting Abstract July 2018

Comparision of Allotopic and Mito targeted ND4 gene therapy for treating Leber Hereditary Optic Neuropathy (LHON) in mice

Rajeshwari D Koilkonda; Hong Yu; Venu Talla; John Guy

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3964.

ARVO Annual Meeting Abstract June 2017

Neutralizing Antibodies Against Adeno-associated virus (AAV)2 Capsids in LHON Gene Therapy Clinical Trial Patients: An Update

Rajeshwari D Koilkonda; William J Feuer; Joyce Schiffman; Janet L Davis; Vittorio Porciatti; Phillip Gonzalez; Byron L Lam; John Guy

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3861.

ARVO Annual Meeting Abstract June 2017

LHON Mouse model carrying human ND1G3460A

Hong Yu; John Guy

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4484.

ARVO Annual Meeting Abstract June 2017

Gene Therapy for LHON Suppresses Neurodegeneration

John Guy; Rajeshwari D Koilkonda; William J Feuer; Janet L Davis; Vittorio Porciatti; Phillip Gonzalez; Huijan Yuan; Byron L Lam

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4492.

ARVO Annual Meeting Abstract June 2017

Gene therapy with constitutively active focal adhesion kinase (FAK) suppresses irreversible visual loss in experimental optic neuritis mice

Venu Talla; M Livia Bajenaru; Vittorio Porciatti; John Guy

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4498.

ARVO Annual Meeting Abstract September 2016

Rescue of a mutant T8993G ATP6 mouse model of NARP and MILS with Mito-Targeted AAV9 Containing Normal ATP6

Huijun Yuan; Hong Yu; John Guy

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):754.

ARVO Annual Meeting Abstract September 2016

Mouse models of Leber Hereditary Optic Neuropathy

Hong Yu; Gabriel Gaidosh; John Guy

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):783.

ARVO Annual Meeting Abstract September 2016

Mitochondria targeted gene therapy for Leber Hereditary Optic Neuropathy (LHON).

John Guy

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12)

ARVO Annual Meeting Abstract September 2016

Gene therapy with constitutively active focal adhesion kinase (FAK) promotes retinal ganglion cells survival and regeneration after optic nerve crush

Michaela Livia Bajenaru; Benjamin Yungher; Xueting Luo; Kevin Park; John Guy; Daniel Pelaez; David T Tse; David Chiu

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4409.

ARVO Annual Meeting Abstract September 2016

Assessment of Neutralizing Antibodies Against Adeno-associated virus (AAV)2 Capsids in Serum and Ocular Fluid Samples of Leber’ Hereditary Optic Neuropathy (LHON) Gene Therapy Clinical Trial Patients

Rajeshwari D Koilkonda; William J Feuer; Joyce C Schiffman; Janet L Davis; Vittorio Porciatti; Phillip Gonzalez; Byron L Lam; John Guy

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5083.

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A new mode of gene therapy to subdue the limitations of the allotopic method: an analytic approach

Leber Hereditary Optic Neuropathy Gene Therapy: Adverse Events and Visual Acuity Results of all Patient Groups

The Relationship Between Stage of Leber's Hereditary Optic Neuropathy and Pattern Electroretinogram Latency

Mitochondrial Transfer of the Mutant Human ND6T14484C Gene Causes Visual Loss and Optic Neuropathy

XIAP Protects Retinal Ganglion Cells in the Mutant ND4 Mouse Model of Leber Hereditary Optic Neuropathy

Kruppel-like factor (KLF4) knockout in retinal ganglion cells improves visual function in Experimental Autoimmune Encephalomyelitis (EAE) mice model of optic neuritis

Photoreceptor damage caused by human mutant T8993G ATP6 in a transgenic mouse model of Leigh syndrome and NARP

Gene Therapy for Leber Hereditary Optic NeuropathY An update of Where We Stand (Clinicaltrials.gov number: NCT02161380)

Novel NDUFV1 mutations with optic nerve atrophy

Mitochondrial transfer of the human ND6T14484C gene causes visual loss and optic neuropathy

Comparision of Allotopic and Mito targeted ND4 gene therapy for treating Leber Hereditary Optic Neuropathy (LHON) in mice

Neutralizing Antibodies Against Adeno-associated virus (AAV)2 Capsids in LHON Gene Therapy Clinical Trial Patients: An Update

LHON Mouse model carrying human ND1G3460A

Gene Therapy for LHON Suppresses Neurodegeneration

Gene therapy with constitutively active focal adhesion kinase (FAK) suppresses irreversible visual loss in experimental optic neuritis mice

Rescue of a mutant T8993G ATP6 mouse model of NARP and MILS with Mito-Targeted AAV9 Containing Normal ATP6

Mouse models of Leber Hereditary Optic Neuropathy

Mitochondria targeted gene therapy for Leber Hereditary Optic Neuropathy (LHON).

Gene therapy with constitutively active focal adhesion kinase (FAK) promotes retinal ganglion cells survival and regeneration after optic nerve crush

Assessment of Neutralizing Antibodies Against Adeno-associated virus (AAV)2 Capsids in Serum and Ocular Fluid Samples of Leber’ Hereditary Optic Neuropathy (LHON) Gene Therapy Clinical Trial Patients

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