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Articles June 2020

Assessment of AAV Dual Vector Safety in the Abca4 −/− Mouse Model of Stargardt Disease

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Michelle E. McClements; Alun R. Barnard; Peter Charbel Issa; Robert E. MacLaren
TAGS: cohort studies, disease vectors, eye, injections, mice, safety, spatial vectors, stargardt's disease, electroretinography, toxic effect
Trans. Vis. Sci. Tech.. 2020; 9(7):20. https://doi.org/10.1167/tvst.9.7.20

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

A semi-automated phenotypic RPE in vitro scratch assay for screening of small molecule compounds able to influence RPE wound healing

Tina storm; Ross Campbell; Iain R Wilson; Arantxa Bolinches-Amoros; Angela J. Russel; Stephen G. Davies; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6394.

ARVO Annual Meeting Abstract July 2019

Assessment of AAV dual vector safety in the Abca4 KO mouse model

Michelle E McClements; Alun R Barnard; Peter Charbel Issa; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1708.

ARVO Annual Meeting Abstract July 2019

Vector shedding and immunology measures in a choroideremia gene therapy trial

Alun R Barnard; Anna Rudenko; Maria In�s Patr�cio; Laurel Clare Chandler; Kanmin Xue; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2919.

ARVO Annual Meeting Abstract July 2019

Photoreceptor-specific AAV gene replacement enhanced by the adjunctive use of hydroxychloroquine in vivo

Laurel Clare Chandler; Michelle E McClements; Alun R Barnard; Maria In�s Patr�cio; Robert E MacLaren; Kanmin Xue

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3391.

ARVO Annual Meeting Abstract July 2019

Guide RNA orientation influences Cas9 expression in a single vector approach to CRISPR editing in a model system

Lewis Fry; Caroline Peddle; Alun R Barnard; Michelle E McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4937.

ARVO Annual Meeting Abstract July 2019

Mirtron gene therapy for the treatment of rhodopsin-related dominant retinitis pigmentosa

Harry Otway Orlans; Michelle E McClements; Alun R Barnard; Cristina Martinez-Fernandez dela Camara; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5195.

ARVO Annual Meeting Abstract July 2019

Fundus autofluorescence abnormalities and microglia/macrophage activation in the Rpgr -deficient mouse.

Federica Staurenghi; Cristina Martinez-Fernandez dela Camara; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):433.

Retina June 2019

Filtration of Short-Wavelength Light Provides Therapeutic Benefit in Retinitis Pigmentosa Caused by a Common Rhodopsin Mutation

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Harry O. Orlans; Jonathon Merrill; Alun R. Barnard; Peter Charbel Issa; Stuart N. Peirson; Robert E. MacLaren
TAGS: filters, filtration, housing, mice, mutation, retinitis pigmentosa, rhodopsin, retinal degeneration, electroretinography, retinal cone
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2733-2742. https://doi.org/10.1167/iovs.19-26964

Includes: Supplemental Content

Retina December 2018

A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3

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Mark M. Hassall; Alun R. Barnard; Harry O. Orlans; Michelle E. McClements; Peter Charbel Issa; Sher A. Aslam; Robert E. MacLaren
TAGS: achromatopsia, mice, retinal cone, electroretinography, mutation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6102-6110. https://doi.org/10.1167/iovs.18-24328

ARVO Annual Meeting Abstract July 2018

Retinal Gene Therapy for Choroideremia in a Multicenter Dose Escalation Phase I/II Clinical Trial

Robert E MacLaren; Kanmin Xue; Alun R Barnard; Maria In?s Patrício; Thomas L Edwards; Susan Downes; Andrew Lotery; Graeme Black; Andrew Webster; Jasleen K Jolly; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1195.

ARVO Annual Meeting Abstract July 2018

Assessment of adjunctive gene therapy to dormant cones in end-stage retinitis pigmentosa

Mark Hassall; Michelle McClements; Alun R Barnard; Sher A Aslam; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):989.

ARVO Annual Meeting Abstract July 2018

Pathological donor splice site mutations beyond the dinucleotide canonical sequence in choroideremia

Lewis Fry; Maria In?s Patrício; Jonathan Williams; Penny Clouston; Kanmin Xue; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3493.

ARVO Annual Meeting Abstract July 2018

Biocompatibility and stability of an AAV vector for choroideremia gene therapy following passage through its surgical device

Maria In?s Patrício; Cristina Martinez-Fernandez Dela Camara; Christopher I Cox; Clare Blue; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4541.

ARVO Annual Meeting Abstract July 2018

Optimization of an in vitro model for assessing the survival of post-mitotic photoreceptors and Müller glial cells

Arantxa Bolinches-Amorós; Tina storm; Angela J. Russell; Stephen G Davies; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4600.

ARVO Annual Meeting Abstract July 2018

The senescence marker P16 ink4a is expressed in ocular astrocytes

Tina storm; Harry Otway Orlans; Cristina Martinez-Fernandez Dela Camara; Arantxa Bolinches-Amorós; Angela J. Russell; Stephen G Davies; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4613.

ARVO Annual Meeting Abstract July 2018

Vector shedding and immunology results from a gene therapy clinical trial for choroideremia

Alun R Barnard; Anna Rudenko; Kanmin Xue; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5654.

ARVO Annual Meeting Abstract July 2018

Hydroxychloroquine enhances the efficacy of retinal gene therapy

Laurel Clare Chandler; Alun R Barnard; Maria In?s Patrício; Kanmin Xue; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6005.

ARVO Annual Meeting Abstract July 2018

An optimized AAV vector for rod-specific gene expression

Harry Otway Orlans; Michelle McClements; Maria In?s Patrício; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4534.

Articles July 2017

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

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Anna P. Salvetti; Maria I. Patrício; Alun R. Barnard; Harry O. Orlans; Doron G. Hickey; Robert E. MacLaren
TAGS: dyes, gene therapy, surgical procedures, operative, spatial vectors, cell survival, injections, toxic effect
Trans. Vis. Sci. Tech.. 2017; 6(4):4. https://doi.org/10.1167/tvst.6.4.4

Includes: Supplemental Content

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Assessment of AAV Dual Vector Safety in the Abca4 −/− Mouse Model of Stargardt Disease

A semi-automated phenotypic RPE in vitro scratch assay for screening of small molecule compounds able to influence RPE wound healing

Assessment of AAV dual vector safety in the Abca4 KO mouse model

Vector shedding and immunology measures in a choroideremia gene therapy trial

Photoreceptor-specific AAV gene replacement enhanced by the adjunctive use of hydroxychloroquine in vivo

Guide RNA orientation influences Cas9 expression in a single vector approach to CRISPR editing in a model system

Mirtron gene therapy for the treatment of rhodopsin-related dominant retinitis pigmentosa

Fundus autofluorescence abnormalities and microglia/macrophage activation in the Rpgr -deficient mouse.

Filtration of Short-Wavelength Light Provides Therapeutic Benefit in Retinitis Pigmentosa Caused by a Common Rhodopsin Mutation

A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3

Retinal Gene Therapy for Choroideremia in a Multicenter Dose Escalation Phase I/II Clinical Trial

Assessment of adjunctive gene therapy to dormant cones in end-stage retinitis pigmentosa

Pathological donor splice site mutations beyond the dinucleotide canonical sequence in choroideremia

Biocompatibility and stability of an AAV vector for choroideremia gene therapy following passage through its surgical device

Optimization of an in vitro model for assessing the survival of post-mitotic photoreceptors and Müller glial cells

The senescence marker P16 ink4a is expressed in ocular astrocytes

Vector shedding and immunology results from a gene therapy clinical trial for choroideremia

Hydroxychloroquine enhances the efficacy of retinal gene therapy

An optimized AAV vector for rod-specific gene expression

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

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