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Special Issue August 2017

Activated Retinal Pigment Epithelium, an Optical Coherence Tomography Biomarker for Progression in Age-Related Macular Degeneration

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Christine A. Curcio; Emma C. Zanzottera; Thomas Ach; Chandrakumar Balaratnasingam; K. Bailey Freund
TAGS: drusen, atrophy, biological markers, eye, histology, age-related macular degeneration, optical coherence tomography, retinal pigment epithelium, spectral-domain optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO211-BIO226. doi: 10.1167/iovs.17-21872

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract June 2017

Hyperspectral Autofluorescence (AF) and Mechanisms of Retinal Pigment Epithelium (RPE) Lipofuscin Loss in Age-Related Macular Degeneration (AMD)

Yuehong Tong; Julia Margaret Agee; Taariq Mohammed; Neel Dey; Sungmin Hong; Rainer Heintzmann; Martin Hammer; Guido Gerig; Christine A. Curcio; Thomas Ach; Zsolt Ablonczy; Theodore Smith

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):404. doi:

Retina April 2017

The Evolution of the Plateau, an Optical Coherence Tomography Signature Seen in Geographic Atrophy

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Anna C. S. Tan; Polina Astroz; Kunal K. Dansingani; Jason S. Slakter; Lawrence A. Yannuzzi; Christine A. Curcio; K. Bailey Freund
TAGS: atrophy, follow-up, diagnostic imaging, eye, optical coherence tomography, spectral-domain optical coherence tomography, volume
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2349-2358. doi: 10.1167/iovs.16-21237

Includes: Multimedia, Supplemental Content

Retinal Cell Biology February 2017

Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model

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Matthew G. Pilgrim; Imre Lengyel; Antonio Lanzirotti; Matt Newville; Sarah Fearn; Eszter Emri; Jonathan C. Knowles; Jeffrey D. Messinger; Russell W. Read; Clyde Guidry; Christine A. Curcio
TAGS: cell culture techniques, immunohistochemistry, diffuse idiopathic skeletal hyperostosis, drusen, epithelium, durapatite, hydroxyapatites, pigment, spectrometry, mass, secondary ion, family suidae, lipids, proteins, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2017; 58(2):708-719. doi: 10.1167/iovs.16-21060

Includes: Supplemental Content

Retina October 2016

Associations Between Retinal Pigment Epithelium and Drusen Volume Changes During the Lifecycle of Large Drusenoid Pigment Epithelial Detachments

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Chandrakumar Balaratnasingam; Lawrence A. Yannuzzi; Christine A. Curcio; William H. Morgan; Giuseppe Querques; Vittorio Capuano; Eric Souied; Jesse Jung; K. Bailey Freund
TAGS: drusen, epithelium, pigment, visual acuity, volume, parents' evaluation of developmental status (pediatric screen), retinal pigment epithelium, parents’ evaluation of developmental status, retinal pigment epithelial detachment, spectral-domain optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5479-5489. doi: 10.1167/iovs.16-19816

ARVO Annual Meeting Abstract September 2016

Variability in fundus autofluorescence (FAF) intensity is locally and globally associated with rod-mediated dark adaptation (RMDA) delay in early age-related macular degeneration (AMD)

Anna V Zarubina; Carrie E Huisingh; Fazila Aseem; Gerald McGwin; Mark Clark; Christine A Curcio; Kenneth R Sloan; Cynthia Owsley

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1620. doi:

ARVO Annual Meeting Abstract September 2016

RNA editing shows differences between macular and peripheral regions of human retina and supporting tissues

David Cho; Christine A Curcio; Dwight Stambolian; Mingyao Li

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Histological stages of subretinal drusenoid deposits (SDD) in eyes with age-related macular degeneration (AMD)

Christine A Curcio; Jeffrey D Messinger; Yuhua Zhang; David Neely; K Bailey Freund; Richard F Spaide

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

What age-related macular degeneration taught us about aging of the retinal pigment epithelium

Christine A Curcio

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Complement genes are differentially expressed in late age-related macular degeneration (AMD) and only in the neurosensory retina

Dwight Stambolian; Christine A Curcio; David Cho; James A. Kimble; Jeffrey D Messinger; Randy Zauhar; Mingyao Li

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

A primary retinal pigment epithelial (RPE) cell culture model produces lipid- and hydroxyapatite-rich extracellular deposits characteristic of early stage age-related macular degeneration

Matthew Glynn Pilgrim; Antonio Lanzirotti; Matt Newville; Sarah Fearn; Jonathan Knowles; Jeffrey D Messinger; Russell W Read; Clyde Guidry; Christine A Curcio; Imre Lengyel

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6535. doi:

ARVO Annual Meeting Abstract September 2016

Confocal adaptive optics differential phase contrast (AODPC) ophthalmoscopy

Xiaolin Wang; Boyu Gu; Jing Lu; Christine A Curcio; Yuhua Zhang

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):60. doi:

ARVO Annual Meeting Abstract September 2016

Histologically guided metrics for semi-automated analysis of fundus autofluorescence (FAF) in aging and age-related macular degeneration (AMD)

Kenneth R Sloan; Anna V Zarubina; Carrie Huisingh; Fazila Aseem; Mark Clark; Gerald McGwin; Yuhua Zhang; Cynthia Owsley; Christine A Curcio

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1618. doi:

ARVO Annual Meeting Abstract September 2016

Dynamism and ultrastructure of subretinal drusenoid deposits revealed by adaptive optics scanning laser ophthalmoscopy over 3.5 years

Yuhua Zhang; Xiaolin Wang; Mark E Clark; Cynthia Owsley; Christine A Curcio

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):78. doi:

ARVO Annual Meeting Abstract September 2016

Differential expression of long noncoding RNAs is correlated with AMD phenotype

Randy Zauhar; David Cho; LiFeng Tian; Mingyao Li; Christine A Curcio; Dwight Stambolian

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Reflectivity of cone photoreceptors in outer retinal tubulation (ORT) in age-related macular degeneration (AMD)

Katie M Litts; Xiaolin Wang; Mark E Clark; Christine A Curcio; Yuhua Zhang

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):29. doi:

ARVO Annual Meeting Abstract September 2016

Organelle distribution and intracellular autofluorescence (AF) spectra in human retinal pigment epithelium (RPE) cells

Katharina Müller; Rainer Heintzmann; Jost Hillenkamp; Christine A Curcio; Thomas Ach

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):30. doi:

ARVO Annual Meeting Abstract September 2016

Hyperspectral Autofluorescence Characterization of Transition to Atrophy in Donor Eyes with Advanced Age-Related Macular Degeneration (AMD)

Yuehong Tong; Tal Ben Ami; Sungmin Hong; Rainer Heintzmann; Guido Gerig; Zsolt Ablonczy; Christine A Curcio; Thomas Ach; Theodore Smith

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):54. doi:

ARVO Annual Meeting Abstract September 2016

Hyperspectral Autofluorescence (AF) of Melanin-containing Organelles in Human Retinal Pigment Epithelium (RPE) with Late Age-related Macular Degeneration (AMD)

Tal Ben Ami; Yuehong Tong; Sungmin Hong; Rainer Heintzmann; Guido Gerig; Zsolt Ablonczy; Christine A Curcio; Thomas Ach; Theodore Smith

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1705. doi:

ARVO Annual Meeting Abstract September 2016

Visualizing retinal pigment epithelium (RPE) melanosomes, lipofuscin, melanolipofuscin (M, L, ML) in human eyes of different ages using 3-dimensional serial block face scanning electron microscopy (3D SBFSEM)

Andreas Pollreisz; Jeffrey D Messinger; Kenneth R Sloan; Emily Benson; Grahame J Kidd; Ursula Schmidt-Erfurth; Christine A Curcio

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

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Activated Retinal Pigment Epithelium, an Optical Coherence Tomography Biomarker for Progression in Age-Related Macular Degeneration

Hyperspectral Autofluorescence (AF) and Mechanisms of Retinal Pigment Epithelium (RPE) Lipofuscin Loss in Age-Related Macular Degeneration (AMD)

The Evolution of the Plateau, an Optical Coherence Tomography Signature Seen in Geographic Atrophy

Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model

Associations Between Retinal Pigment Epithelium and Drusen Volume Changes During the Lifecycle of Large Drusenoid Pigment Epithelial Detachments

Variability in fundus autofluorescence (FAF) intensity is locally and globally associated with rod-mediated dark adaptation (RMDA) delay in early age-related macular degeneration (AMD)

RNA editing shows differences between macular and peripheral regions of human retina and supporting tissues

Histological stages of subretinal drusenoid deposits (SDD) in eyes with age-related macular degeneration (AMD)

What age-related macular degeneration taught us about aging of the retinal pigment epithelium

Complement genes are differentially expressed in late age-related macular degeneration (AMD) and only in the neurosensory retina

A primary retinal pigment epithelial (RPE) cell culture model produces lipid- and hydroxyapatite-rich extracellular deposits characteristic of early stage age-related macular degeneration

Confocal adaptive optics differential phase contrast (AODPC) ophthalmoscopy

Histologically guided metrics for semi-automated analysis of fundus autofluorescence (FAF) in aging and age-related macular degeneration (AMD)

Dynamism and ultrastructure of subretinal drusenoid deposits revealed by adaptive optics scanning laser ophthalmoscopy over 3.5 years

Differential expression of long noncoding RNAs is correlated with AMD phenotype

Reflectivity of cone photoreceptors in outer retinal tubulation (ORT) in age-related macular degeneration (AMD)

Organelle distribution and intracellular autofluorescence (AF) spectra in human retinal pigment epithelium (RPE) cells

Hyperspectral Autofluorescence Characterization of Transition to Atrophy in Donor Eyes with Advanced Age-Related Macular Degeneration (AMD)

Hyperspectral Autofluorescence (AF) of Melanin-containing Organelles in Human Retinal Pigment Epithelium (RPE) with Late Age-related Macular Degeneration (AMD)

Visualizing retinal pigment epithelium (RPE) melanosomes, lipofuscin, melanolipofuscin (M, L, ML) in human eyes of different ages using 3-dimensional serial block face scanning electron microscopy (3D SBFSEM)

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