@article{10.1167/iovs.12-9483o,
    author = {Borrás, Terete},
    title = "{Advances in Glaucoma Treatment and Management: Gene Therapy}",
    journal = {Investigative Ophthalmology & Visual Science},
    volume = {53},
    number = {5},
    pages = {2506-2510},
    year = {2012},
    month = {05},
    abstract = "{Gene therapy vectors deliver the genetic material to the inside of the cells. Because viruses have been selected during evolution to cleanly and efficiently enter living cells, they have emerged as excellent carriers of any desired genetic material. Given the tools of molecular biology and recombinant DNA that are now available, a virus can be specially engineered both to remove the potentially deleterious sequences from its genome and to insert the beneficial foreign sequences to be delivered to the target cell.Because of this particular physiology, there are two main avenues to follow in approaching research in gene therapy for glaucoma. The first entails targeting the RGCs with the goal of promoting their survival and protecting them against glaucomatous insults (neuroprotection). The second entails targeting the TM with the goal of lowering IOP.}",
    issn = {1552-5783},
    doi = {10.1167/iovs.12-9483o},
    url = {https://doi.org/10.1167/iovs.12-9483o},
    eprint = {https://arvojournals.org/arvo/content\_public/journal/iovs/932975/z7g00512002506.pdf},
}