RT Journal Article
A1 Shah, Ameet
A1 Lascaratos, Gerassimos
A1 Garway-Heath, David F.
A1 Foster, Paul J.
A1 Barton, Keith
T1 Longitudinal Study of Iris Concavity, Corneal Biomechanics, and Correlations to Ocular Biometry in a Cohort of 10- to 12-Year-Old UK Schoolboys: 2-Year Follow-up Data
JF Investigative Ophthalmology & Visual Science
JO Invest. Ophthalmol. Vis. Sci.
YR 2014
DO 10.1167/iovs.13-13757
VO 55
IS 7
SP 4645
OP 4650
SN 1552-5783
AB    To explore changes in iris curvature over a 2-year period. To investigate associations between iris curvature and ocular biometric parameters. To explore relationships between a number of nonocular measurements and ocular biometric parameters.    Schoolboys enrolled 2 years previously were invited to return for anterior segment optical coherence tomography, corneal hysteresis (CH), corneal resistance factor (CRF), and axial biometric measurements. Refractive error was assessed and measures of height, weight, waist circumference, digit ratio, and percentage body fat taken.    Mean spherical equivalent refraction reduced by 0.76 diopters and mean iris concavity, defined as a measurement of less than or equal to −0.1 mm, increased by 0.018 mm at distance fixation and 0.04 mm on accommodation. Compared with 2 years previously, the prevalence of iris concavity increased from 24% to 32% on distance fixation and from 65% to 84% on accommodation. Variables significantly associated with nonaccommodating iris curvature were anterior chamber depth (ACD, P = 0.029) and mean scleral spur angle (P = 0.0001). Variables significantly associated with accommodating iris curvature were ACD (P = 0.02), lens vault (P = 0.047), and scleral spur angle (P < 0.0001). Significant association was again found between CH and accommodating spur-to-spur distance (R 2 = 0.13, P = 0.007).    Iris concavity was more prevalent in this cohort of schoolboys than 2 years earlier. The degree of concavity remains related to ACD and lens vault. The association between spur-to-spur distance and CH was similar at baseline and after 2 years.  
RD 4/21/2021
UL https://doi.org/10.1167/iovs.13-13757