RT Journal Article
A1 Bazan, Nicolas G.
T1 Homeostatic Regulation of Photoreceptor Cell Integrity: Significance of the Potent Mediator Neuroprotectin D1 Biosynthesized from Docosahexaenoic Acid The Proctor Lecture
JF Investigative Ophthalmology & Visual Science
JO Invest. Ophthalmol. Vis. Sci.
YR 2007
DO 10.1167/iovs.07-0918
VO 48
IS 11
SP 4866
OP 4881
SN 1552-5783
AB Vision is sustained by a unique and beautiful relationship—that between photoreceptor cells and retinal pigment epithelial (RPE) cells. From the harmony of this cellular relationship emerges the life-long survival of the photoreceptor cell, despite the fact that the part of the eye where these cells interact is continuously exposed to potentially damaging factors. This relationship is one of the best examples of homeostasis in action as conceptualized for other cells and organs in 1932 by the physiologist Walter B. Cannon in The Wisdom of the Body (New York: W. W. Norton, 1932). Emerging questions to elucidate the intimacy of the successful intercellular relationship between photoreceptors and RPE include: How is integrity of the photoreceptor cell sustained? Does photoreceptor cell outer segment renewal modulate specific survival signaling to support the RPE cell during oxidative and nitrosylative challenges? The answers to these questions are needed to better our understanding of and to develop therapies for retinitis pigmentosa (RP), macular degenerations, and other retinal diseases.
RD 4/4/2020
UL https://doi.org/10.1167/iovs.07-0918