RT Journal Article A1 Elena, P.-P. A1 Pollin, C. A1 Bermon, F. A1 Amar, T. A1 Caillaud, T. A1 Polzer, H. T1 Snapshot Test for Investigating Gels of Anti-Glaucoma Compounds as Topical Formulations JF Investigative Ophthalmology & Visual Science JO Invest. Ophthalmol. Vis. Sci. YR 2009 VO 50 IS 13 SP 6002 OP 6002 SN 1552-5783 AB To get predictive data on the ocular penetration of several compounds formulated as mucoadhesive polymer fluid gels in a time-sharing, money-saving test. A single topical application of several 0.1% and 0.2% brimonidine tartrate formulations (mixture with various mixed polymers MP formulations: carbomer, polyvinylalcohol, povidone, etc...) into both eyes of pigmented rabbits, was compared to Alphagan® P 0.1%, Alphagan® P 0.15%, and Alphagan® 0.2%. The aqueous humor was sampled 15min, 30min, 40min, 60min, 120min, and 240min after treatment, and brimonidine content was evaluated by HPLC-MS. Compared to Alphagan®, both the area under the curve (AUC15-240min) ratios and the Cmax ratios (at 40min) were within a same range, as shown in the following table:Formulation Cmax ratio vs Alphagan® AUC15-240min ratio vs Alphagan®Alphagan® 0.2% 1.00 1.00Alphagan® P 0.15% 0.64 0.95Alphagan® P 0.1% 0.73 0.82MP 701-04509-01 0.1% 1.05 0.88MP 701-04509 0.2% 1.58 2.33MP 730-0450901 0.2% 2.05 1.75MP 700-04509 0.2% 1.59 1.83Similar experiments were performed using 0.1%-timolol/2%-dorzolamide formulations vs Cosopt® and showed similar results. RD 1/19/2021