%0 Journal Article %A Mai, T. %A Schoot, J. G. van der %A Reus, N. J. %A Colen, T. P. %A Lemij, H. G. %T Progression Analysis in Perimetrically Unaffected Eyes of Glaucoma Patients With Scanning Laser Polarimetry %B Investigative Ophthalmology & Visual Science %D 2008 %J Investigative Ophthalmology & Visual Science %V 49 %N 13 %P 4641-4641 %@ 1552-5783 %X Purpose: 1. To compare the proportion of progressing eyes and the time to progression, determined by the GDx progression analysis program (GPA), NFI change (reproducibly exceeding 35 or increasing ≥ 7), and conversion on VF (VF change), in initially perimetrically unaffected eyes of glaucoma patients with monocular visual field loss. 2. To explore the agreement in eye classification (progressing vs. non-progressing) between methods. Methods: In 34 primary open-angle glaucoma patients, we performed 6 monthly GDx VCC imaging and standard automated perimetry (SAP) over a period of 51.6 (SD = 0.7) months. Results: Eleven eyes (32.4%) were classified by 1 of 3 methods as progressing, whereas 5 eyes (45.5%) were classified by all 3. With GPA, 20.6% (7 eyes) showed progression; with the NFI change and VF change, this was 23.5% (7 eyes) and 20.6% (8 eyes), respectively. These percentages were similar for the 3 methods (p = 1.0, pair-wise comparisons). No differences in time to progression between these 3 methods were observed (p = 0.829). At baseline, 44.1% (15/34) of the eyes already had an NFI ≥ 35, of which 20% (3/15) showed progression during the follow-up (2 with all 3 methods and 1 with GPA and NFI change only). Of the eyes with an NFI < 35 at baseline, 26.3% (5/19) progressed. Conclusions: Although the proportion of progressing eyes in the initially perimetrically unaffected eyes of glaucoma patients with monocular VF loss did not differ between the 3 methods, not all methods identified the same eyes as progressing. Structural change detection was at least as sensitive as functional change detection; in many eyes it was even more sensitive. %[ 6/24/2021