RT Journal Article
A1 Mai, T.
A1 Schoot, J. G. van der
A1 Reus, N. J.
A1 Colen, T. P.
A1 Lemij, H. G.
T1  Progression Analysis in Perimetrically Unaffected Eyes of Glaucoma Patients With Scanning Laser Polarimetry
JF Investigative Ophthalmology & Visual Science
JO Invest. Ophthalmol. Vis. Sci.
YR 2008
VO 49
IS 13
SP 4641
OP 4641
SN 1552-5783
AB  Keywords: retina • optic nerve • imaging/image analysis: clinical   Purpose:  1. To compare the proportion of progressing eyes and the time to progression, determined by the GDx progression analysis program (GPA), NFI change (reproducibly exceeding 35 or increasing ≥ 7), and conversion on VF (VF change), in initially perimetrically unaffected eyes of glaucoma patients with monocular visual field loss. 2. To explore the agreement in eye classification (progressing vs. non-progressing) between methods.     Methods:  In 34 primary open-angle glaucoma patients, we performed 6 monthly GDx VCC imaging and standard automated perimetry (SAP) over a period of 51.6 (SD = 0.7) months.     Results:  Eleven eyes (32.4%) were classified by 1 of 3 methods as progressing, whereas 5 eyes (45.5%) were classified by all 3. With GPA, 20.6% (7 eyes) showed progression; with the NFI change and VF change, this was 23.5% (7 eyes) and 20.6% (8 eyes), respectively. These percentages were similar for the 3 methods (p = 1.0, pair-wise comparisons). No differences in time to progression between these 3 methods were observed (p = 0.829). At baseline, 44.1% (15/34) of the eyes already had an NFI ≥ 35, of which 20% (3/15) showed progression during the follow-up (2 with all 3 methods and 1 with GPA and NFI change only). Of the eyes with an NFI < 35 at baseline, 26.3% (5/19) progressed.     Conclusions:  Although the proportion of progressing eyes in the initially perimetrically unaffected eyes of glaucoma patients with monocular VF loss did not differ between the 3 methods, not all methods identified the same eyes as progressing. Structural change detection was at least as sensitive as functional change detection; in many eyes it was even more sensitive.    
RD 4/1/2020