%0 Journal Article
%A Tomita, M.
%A Wang, M. C.
%A Taniguchi, H.
%A Takahashi, H.
%A Shimazaki, J.
%A Yagita, H.
%A Hori, J.
%T  Tim-3 Is Necessary for Corneal Allograft Survival
%B Investigative Ophthalmology & Visual Science
%D 2008
%J Investigative Ophthalmology & Visual Science
%V 49
%N 13
%P 5755-5755
%@ 1552-5783
%X    T cell immunoglobulin and mucin domain (Tim)-3 is a helper T (Th) 1 cell-specific antigen that was implicated to play a role in the maintenance of peripheral tolerance. The purpose of the present study was to determine the role of Tim-3 in immune privilege of corneal allografts.     Normal corneas of C57BL/6 were transplanted orthotopically into normal eyes of BALB/c mice. Recipients were administrated with 0.2 mg of anti-Tim-3 monoclonal antibodies or control rat IgG intraperitoneally, three times a week for 8 weeks after grafting. Graft survival was assessed clinically and was compared with control. Expression of Tim-3 in normal corneas and in allografts was examined immunohistochemically by confocal microscopy.     Allografts survival in anti-Tim-3 group was significantly shorter than that in the control group (p<0.05). Tim-3 expression was found on CD4-positive T cells in the posterior surface of allografts.     Tim-3 plays a role on the acceptance of corneal allografts. Tim-3 positive CD4 positive T cells infiltrating in the corneal grafts may have a role in the maintenance of allografts survival within the cornea.   
%[ 2/24/2021