RT Journal Article
A1 Cho, Kwan Hyuk
A1 Kim, Chi Kyung
A1 Oh, Kyungmi
A1 Oh, Seung-Won
A1 Park, Kyu Hyung
A1 Park, Sang Jun
T1 Retinal Vein Occlusion as the Surrogate Marker for Premature Brain Aging in Young Patients
JF Investigative Ophthalmology & Visual Science
JO Invest. Ophthalmol. Vis. Sci.
YR 2017
DO 10.1167/iovs.17-21413
VO 58
IS 6
SP BIO82
OP BIO87
SN 1552-5783
AB    We investigated cerebral small vessel disease (SVD) in patients with incidental retinal vein occlusion (RVO).    This retrospective, case-control, observational trial included 125 patients with RVO who underwent brain magnetic resonance imaging (MRI) and 1105 age-matched controls who underwent comprehensive medical interviews and MRI. Underlying cardiovascular diseases and MRI findings were investigated in the patients with RVO according to age (<60 or ≥60 years) and RVO occlusion level (central or branch). The characteristics of underlying cardiovascular disease and MRI findings were compared between the younger patients with RVO and age-matched controls. The cerebrovascular burden also was assessed in the younger patients with RVO.    The mean age of the patients with RVO was 63.9 ± 12.1 years and the predominant underlying disease was hypertension (72/125, 58%). The older RVO group had a longer history of hypertension and less smoking history. The prevalence of cerebral SVD in the RVO group was 54% (68/125), and was significantly higher in older than in younger patients with RVO (62% [53/86] vs. 38% [15/39], P = 0.016). However, the latter had a significantly higher prevalence of cerebral SVD than their age-matched controls (38% [15/39] vs. 4% [47/1105], P < 0.001). There was no difference in prevalence of cerebral SVD between the central and branch RVO groups (P = 0.478).    Cerebral SVD presented frequently in patients with RVO and was magnified in young patients, suggesting that RVO is a surrogate marker for cerebral SVD.  
RD 2/26/2021
UL https://doi.org/10.1167/iovs.17-21413