RT Journal Article
A1 Schellevis, Rosa L.
A1 Altay, Lebriz
A1 Kalisingh, Asha
A1 Mulders, Timo W. F.
A1 Sitnilska, Vasilena
A1 Hoyng, Carel B.
A1 Boon, Camiel J. F.
A1 Groenewoud, Joannes M. M.
A1 de Jong, Eiko K.
A1 den Hollander, Anneke I.
T1 Elevated Steroid Hormone Levels in Active Chronic Central Serous Chorioretinopathy
JF Investigative Ophthalmology & Visual Science
JO Invest. Ophthalmol. Vis. Sci.
YR 2019
DO 10.1167/iovs.19-26781
VO 60
IS 10
SP 3407
OP 3413
SN 1552-5783
AB    Chronic central serous chorioretinopathy (cCSC) is characterized by fluid accumulation between photoreceptors and the retinal pigment epithelium of which the cause is unknown. Associations with steroid use, stress, pregnancy, and the male sex suggest a role for the steroid hormone system in the disease. Here, we performed a comprehensive analysis of the steroid hormone system in active cCSC.    Serum hormone levels of 17 steroid hormones were measured in 46 male Caucasian patients with active cCSC and 46 male Caucasian age-matched controls using the AbsoluteIDQ stero17 kit.    Elevated levels of androsterone, estrone, etiocholanolone, and androstenedione were observed in cCSC patients compared with controls. Median hormone levels in cCSC patients versus controls, respectively, were as follows: androsterone, 0.84 ng/mL (interquartile range [IQR] = 0.61–1.06) versus 0.69 ng/mL (IQR = 0.48–0.96, P = 0.031); estrone, 0.12 ng/mL (IQR = 0.10–0.15) versus 0.10 ng/mL (IQR = 0.08–0.11; P = 0.0048); etiocholanolone, 0.19 ng/mL (IQR = 0.15–0.29) versus 0.13 ng/mL (IQR = 0.099–0.20, P = 0.0061). Mean levels of androstenedione were 3.10 ng/ml (SD = 1.03) versus 2.55 ng/mL (SD = 0.95), in cCSC patients versus controls, respectively. Additionally, Spearman's correlations between aldosterone and 11-deoxycortisol, androsterone, DHEA, DHEAS, and E1 differed between cCSC patients and controls, as well as between andosterone and E1, and between DHT and 17OHP.    We present a comprehensive overview of the status of the steroid hormone system in active cCSC. Levels of four hormones were elevated in cCSC patients compared with controls, and the relationships between steroid hormones was altered, indicating that the balance in the steroid hormone system is altered in cCSC patients.  
RD 8/14/2020
UL https://doi.org/10.1167/iovs.19-26781