April 1971
Volume 10, Issue 4
Free
Articles  |   April 1971
The Effect of Salicylates on Aqueous Fibrinolysin
Author Affiliations
  • JUDSON P. SMITH, III
    Department of Ophthalmology, University of Texas Medical Branch, Galveston, Texas.
  • GERALD R. CHRISTENSEN
    Department of Ophthalmology, University of Texas Medical Branch, Galveston, Texas.
Investigative Ophthalmology & Visual Science April 1971, Vol.10, 266-269. doi:
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      JUDSON P. SMITH, GERALD R. CHRISTENSEN; The Effect of Salicylates on Aqueous Fibrinolysin. Invest. Ophthalmol. Vis. Sci. 1971;10(4):266-269.

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Abstract

Assuming that fibrinolytic activity may play a role in cases of recurrent bleeding in traumatic hyphema, a microassay method for determining fibrinolytic activity in the aqueous humor was developed. Results indicate that the rabbit aqueous contains relatively low levels of fibrinolysin and high levels of fibrinolysin activators. Systemic administration of acetylsalicylic acid in therapeutic doses is shown to reduce the fibrinolytic activity in the aqueous of the rabbit substantially.

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