April 1971
Volume 10, Issue 4
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Articles  |   April 1971
Ocular Hypertensive Response Following Acid and Alkali Burns in Rabbits
Author Affiliations
  • TZU SUNG CHIANG
    Division of Ophthalmology, Medical College of Georgia, Augusta, Ga.
  • LARRY R. MOORMAN
    Division of Ophthalmology, Medical College of Georgia, Augusta, Ga.
  • ROBERT P. THOMAS
    Division of Ophthalmology, Medical College of Georgia, Augusta, Ga.
Investigative Ophthalmology & Visual Science April 1971, Vol.10, 270-273. doi:
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      TZU SUNG CHIANG, LARRY R. MOORMAN, ROBERT P. THOMAS; Ocular Hypertensive Response Following Acid and Alkali Burns in Rabbits. Invest. Ophthalmol. Vis. Sci. 1971;10(4):270-273.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Topical administration of hydrochloric acid, sodium hydroxide, and ammonium hydroxide produced a sustained dose-related rise in the intraocular pressure in rabbits. The ocular hypertensive response to sodium hydroxide consisted of a rapid initial rise followed by a gradual second rise. A quaitatively similar response with a smaller secondary rise was observed with the ammonium hydroxide burn. The response to hydrochloric acid was gradual in onset and was maximal within ten to 30 minutes after administration. At the highest concentration tested (2N) the ocular hypertensive responses to sodium hydroxide and hydrochloric acid persisted for three hours.

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