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TZU SUNG CHIANG, LARRY R. MOORMAN, ROBERT P. THOMAS; Ocular Hypertensive Response Following Acid and Alkali Burns in Rabbits. Invest. Ophthalmol. Vis. Sci. 1971;10(4):270-273.
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Topical administration of hydrochloric acid, sodium hydroxide, and ammonium hydroxide produced a sustained dose-related rise in the intraocular pressure in rabbits. The ocular hypertensive response to sodium hydroxide consisted of a rapid initial rise followed by a gradual second rise. A quaitatively similar response with a smaller secondary rise was observed with the ammonium hydroxide burn. The response to hydrochloric acid was gradual in onset and was maximal within ten to 30 minutes after administration. At the highest concentration tested (2N) the ocular hypertensive responses to sodium hydroxide and hydrochloric acid persisted for three hours.
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