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J. A. JEDZINIAK, J. H. KINOSHITA; Activators and Inhibitors of Lens Aldose Reductase. Invest. Ophthalmol. Vis. Sci. 1971;10(5):357-366.
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Aldose reductase in a highly purified state is unstable. It requires the presence of thiol groups to maintain it in an active form. The enzyme apparently exists in 3 forms, only one of which is active. Tetramethylene glutaric acid (TMG) is an effective aldose reductase inhibitor. However, a relatively high level of TMG is needed to depress dulcitol synthesis in the lens incubated in a galactose containing medium. TPN+, a product of the reaction, also inhibits the enzyme. The action of these inhibitors appears to transform the active into inactive enzyme.
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