September 1972
Volume 11, Issue 9
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Articles  |   September 1972
Corneal Amino Acid Supply and Distribution
Author Affiliations
  • RICHARD A. THOFT
    Department of Cornea Research, Retina Foundation, and the Cornea Service, Massachusetts Eye and Ear Infirmary, Boston
  • JUDITH FRIEND
    Department of Cornea Research, Retina Foundation, and the Cornea Service, Massachusetts Eye and Ear Infirmary, Boston
Investigative Ophthalmology & Visual Science September 1972, Vol.11, 723-727. doi:
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      RICHARD A. THOFT, JUDITH FRIEND; Corneal Amino Acid Supply and Distribution. Invest. Ophthalmol. Vis. Sci. 1972;11(9):723-727.

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Abstract

The distribution of nonmetabolized carbon 14-labelled α-aminoisobutyric acid (α-AIB) in the anterior segment of the rabbit eye has been determined in vivo. In addition to confirming earlier observations of the active accumulation of the molecule by the lens, the distribution in the cornea was found to favor the hypothesis of passive diffusion through the corneal endothelial layer and active uptake by the epithelium. The passive role of the endothelium was shown also by measuring the flux of α-AIB across the anterior stromal surface. This flux was substantially greater in the absence of endothelium. The active accumulation of α-AIB by the corneal epithelium occurred only when the molecule was present on the stromal side. A significant barrier to diffusion as well as no evidence of active uptake teas found when the molecule was present in the tears.

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