September 1972
Volume 11, Issue 9
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Articles  |   September 1972
Cocaine-Binding by the Pigmented and the Nonpigmented Iris and its Relevance to the Mydriatic Effect
Author Affiliations
  • P. N. PATIL
    The College of Pharmacy, The Ohio State University, Columbus
Investigative Ophthalmology & Visual Science September 1972, Vol.11, 739-746. doi:
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      P. N. PATIL; Cocaine-Binding by the Pigmented and the Nonpigmented Iris and its Relevance to the Mydriatic Effect. Invest. Ophthalmol. Vis. Sci. 1972;11(9):739-746.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Isolated hides from albino and nonalbino guinea pigs were incubated with various concentrations of (±)-14C-cocaine. The nonpigmented iris accumulated little drug, while the pigmented iris accumulated very large amounts. The ratio for the accumulation was 1:18. Drug accumulated by the nonpigmented iris could be easily washed off at a single exponential rate toith t½ of 10 minutes. The drug accumulated by pigmented iris was resistant to ivashing. In the pigmented iris (-)-ephedrine reduced the accumulation of (±)-14C-cocaine. The drug is also accumulated by the bovine melanin granules. Chemical sympathectomy toith 6-OH-dopamine or phenoxybenzamine treatment, which drastically reduced the uptake of (-)-14C-norepinephrine, failed to reduce the accumulation of (±)-14C-cocaine. As compared to the effect in the pigmented iris, nonlabelled cocaine was the more effective inhibitor of (-)-14C-norepinephrine uptake in the nonpigmented iris. Melanin pigment appears to be a site of loss for the ocular drugs like cocaine, so that a lesser concentration of the drug is available for the interaction with the adrenergic neurones to produce lesser mydriatic effects in the pigmented iris. In the nonpigmented iris, a majority of the drug will be available for interaction toith the neurons to produce greater mydriatic effects.

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