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PHILIP P. ELLIS, KATHRINE LITTLEJOHN, RICHARD A. DEITRICH; Enzymatic Hydrolysis of Pilocarpine. Invest. Ophthalmol. Vis. Sci. 1972;11(9):747-751.
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Enzymatic hydrolysis of pilocarpine by rabbit and human serum, ocular tissues, and liver was demonstrated. Within each species the enzyme concentration in ocidar tissues appeared highest in uveal and retinal tissues and lowest in the lens. The Michaelis-Menten constants (Km) for the pilocarpine inactivating enzyme was 6.04 ± 2.52 x 10-4 M. for rabbit serum and 4.63 ± 2.02 x 10-3 M. for human serum.
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