September 1972
Volume 11, Issue 9
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Articles  |   September 1972
Enzymatic Hydrolysis of Pilocarpine
Author Affiliations
  • PHILIP P. ELLIS
    Division of Ophthalmology and Department of Pharmacology, University of Colorado Medical Center, Denver
  • KATHRINE LITTLEJOHN
    Division of Ophthalmology and Department of Pharmacology, University of Colorado Medical Center, Denver
  • RICHARD A. DEITRICH
    Division of Ophthalmology and Department of Pharmacology, University of Colorado Medical Center, Denver
Investigative Ophthalmology & Visual Science September 1972, Vol.11, 747-751. doi:
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      PHILIP P. ELLIS, KATHRINE LITTLEJOHN, RICHARD A. DEITRICH; Enzymatic Hydrolysis of Pilocarpine. Invest. Ophthalmol. Vis. Sci. 1972;11(9):747-751.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Enzymatic hydrolysis of pilocarpine by rabbit and human serum, ocular tissues, and liver was demonstrated. Within each species the enzyme concentration in ocidar tissues appeared highest in uveal and retinal tissues and lowest in the lens. The Michaelis-Menten constants (Km) for the pilocarpine inactivating enzyme was 6.04 ± 2.52 x 10-4 M. for rabbit serum and 4.63 ± 2.02 x 10-3 M. for human serum.

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