September 1972
Volume 11, Issue 9
Free
Articles  |   September 1972
The Filtration Coefficient of the Blood-Aqueous Barrier
Author Affiliations
  • RICHARD F. BRUBAKER
    Eye Physiology Laboratory, the Department of Ophthalmology, The Mayo Clinic Rochester, Minn.
  • FENWICK C. RILEY
    Eye Physiology Laboratory, the Department of Ophthalmology, The Mayo Clinic Rochester, Minn.
Investigative Ophthalmology & Visual Science September 1972, Vol.11, 752-759. doi:
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      RICHARD F. BRUBAKER, FENWICK C. RILEY; The Filtration Coefficient of the Blood-Aqueous Barrier. Invest. Ophthalmol. Vis. Sci. 1972;11(9):752-759.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The effect of transient osmotic pressure gradients on the volume flux across the blood-aqueous barrier was measured in anesthetized rhesus monkeys. Disturbance of the steady-state osmotic gradient was accomplished by intravenous injection of dextran (average molecular weight 70,000) or by intravenous injection of mannitol. Intraocular pressure and arterial blood pressure were controlled at a steady level during the injection. Changes in volume flux across the bloodtissue barrier of the eye were measured and corrected for small changes of venous pressure which occurred during the injection. The filtration coefficient of the whole eye to water was calculated. This coefficient is comparable to the value of "A" of Brny's model.

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