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RICHARD F. BRUBAKER, FENWICK C. RILEY; The Filtration Coefficient of the Blood-Aqueous Barrier. Invest. Ophthalmol. Vis. Sci. 1972;11(9):752-759.
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The effect of transient osmotic pressure gradients on the volume flux across the blood-aqueous barrier was measured in anesthetized rhesus monkeys. Disturbance of the steady-state osmotic gradient was accomplished by intravenous injection of dextran (average molecular weight 70,000) or by intravenous injection of mannitol. Intraocular pressure and arterial blood pressure were controlled at a steady level during the injection. Changes in volume flux across the bloodtissue barrier of the eye were measured and corrected for small changes of venous pressure which occurred during the injection. The filtration coefficient of the whole eye to water was calculated. This coefficient is comparable to the value of "A" of Brny's model.
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