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GARY L. FORREST, SIDNEY FUTTERMAN; Age-Related Changes in the Retinal Capillaries and the Fatty Acid Composition of Retinal Tissue of Normal and Essential Fatty Acid-Deficient Rats. Invest. Ophthalmol. Vis. Sci. 1972;11(9):760-764.
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Changes with time in the relative proportion of intramural pericytes and endothelial cells in capillaries of the retina were examined in essential fatty acid-deficient rats and their safflower oil-supplemented controls. The ratio of pericytes to endothelial cells rose, approaching a maximum value near unity only at about 9 months past weaning. The changes were identical in both groups. In the deficient animals' retinal tissue 5,8,11-epicosatrienoate was accumulated and arachidonate was reduced. In both groups 4,7,10,13,16-docosapentaenoate accumulated. It was concluded that altered fatty acid composition of the magnitude occurring in essential fatty acid-deficiency was insufficient to provoke pathologic changes in the capillaries within the times of observation covered by these experiments.
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