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YOSHIHITO HONDA; Quantitative Analysis of Some Effects of Ouabain Upon the Electrical Activity of Mammalian Retinas. Invest. Ophthalmol. Vis. Sci. 1972;11(8):699-705.
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The effect of ouabain upon the electroretinogram (ERG) was evaluated quantitatively in excised, perfused rabbit retinas. Ouabain, at concentrations ranging from 10-5 to 10-6 Mol. per liter, enhanced the P II component of the ERG, initially. Later the amplitude of P II decreased. The slowly decaying negative potential, identified as P II, was enhanced initially, but on a time course different from that of P II. The mean halfiife of P II was about 1.5,6, 15, and 50 minutes after administration of 10-4, 10-5, 10-6, and 10-7 Mol. per liter of ouabain, respectively, while corresponding values for P III were about 3, 30, 50, and more than 80 minutes. The minimum effective dose which resulted in a change in the electrophysiological properties of excised, perfused rabbit retinas was found to be lower than that reported for frog retinas.
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